Patents by Inventor Shawn Zinnen

Shawn Zinnen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050209180
    Abstract: This invention relates to compounds, compositions, and methods useful for modulating HCV gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of HCV gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of HCV genes.
    Type: Application
    Filed: September 15, 2004
    Publication date: September 22, 2005
    Applicant: Sirna Therapeutics, Inc.
    Inventors: Vasant Jadhav, Karl Kossen, Shawn Zinnen, Narendra Vaish, James McSwiggen
  • Publication number: 20050203044
    Abstract: The present invention concerns small-mer compositions and methods useful in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small-mer compositions capable of inhibiting viral replication, useful in treating diseases and conditions related to viral infection, and/or capable of inhibiting cellular proliferation, useful in treating diseases and conditions related to cellular proliferation.
    Type: Application
    Filed: January 26, 2005
    Publication date: September 15, 2005
    Applicant: Sirna Therapeutics, Inc.
    Inventor: Shawn Zinnen
  • Publication number: 20050020525
    Abstract: The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
    Type: Application
    Filed: January 14, 2004
    Publication date: January 27, 2005
    Inventors: James McSwiggen, Bharat Chowrira, Leonid Beigelman, Dennis Macejak, Shawn Zinnen, Pamela Pavco, Peter Haeberli, David Morissey, Kathy Fosnaugh, Sharon Jamison, Nassim Usman, James Thompson, Chandra Vargeese, Weimen Wang, Tonqian Chen, Narendra Vaish
  • Publication number: 20040192626
    Abstract: The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
    Type: Application
    Filed: May 23, 2003
    Publication date: September 30, 2004
    Inventors: James McSwiggen, Bharat Chowrira, Leonid Beigelman, Dennis Macejak, Shawn Zinnen, Pamela Pavco, Peter Haeberli, David Morrissey, Kathy Fosnaugh, Sharon Jamison, Nassim Usman, James Thompson, Chandra Vargeese, Weimin Wang, Tongqian Chen, Narendra Vaish
  • Publication number: 20040009510
    Abstract: Nucleic acid sensor molecules and methods are provided for the detection and amplification of signaling agents using enzymatic nucleic acid constructs, including Halfzymes, multicomponent nucleic acid sensor molecules, hammerhead enzymatic nucleic acid molecules, inozymes, G-cleaver enzymatic nucleic acid molecules, zinzymes, amberzymes and DNAzymes. Also provided are kits for detection and amplification. The nucleic acid sensor molecules, methods and kits provided herein can be used in diagnostics, nucleic acid circuits, nucleic acid computers, therapeutics, target validation, target discovery, drug optimization, single nucleotide polymorphism (SNP) detection, single nucleotide polymorphism (SNP) scoring, and proteome scoring as well as other uses described herein.
    Type: Application
    Filed: April 23, 2003
    Publication date: January 15, 2004
    Inventors: Scott Seiwert, Narendra Vaish, Shawn Zinnen, Vasant Jadhav, Karl Kossen
  • Patent number: 6617438
    Abstract: Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. Also, described are the use of novel enzymatic nucleic acid molecules to inhibit HER2/neu/ErbB2 gene expression and their applications in human therapy.
    Type: Grant
    Filed: December 30, 1999
    Date of Patent: September 9, 2003
    Assignee: Sirna Therapeutics, Inc.
    Inventors: Leonid Beigelman, Alex B. Burgin, Amber Beaudry, Alexander Karpeisky, Jasenka Matulic-Adamic, David Sweedler, Shawn Zinnen
  • Publication number: 20030144489
    Abstract: Nucleic acid catalysts, method of screening for variants of nucleic acid catalysts, synthesis of enzymatic nucleic acid molecule libraries and discovery of gene sequences are described.
    Type: Application
    Filed: May 28, 2002
    Publication date: July 31, 2003
    Inventors: Alex Burgin, Leonid Beigelman, Laurent Bellon, Shawn Zinnen
  • Publication number: 20030130186
    Abstract: This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including galactose, galactosamine, N-acetyl galactosamine, PEG, phospholipid, peptide and human serum albumin (HSA) derived conjugates of biologically active compounds, including antibodies, antivirals, chemotherapeutics, peptides, proteins, hormones, nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids, DNAzymes, allozymes, antisense, dsRNA, siRNA, triplex oligonucleotides, 2,5-A chimeras, decoys and aptamers.
    Type: Application
    Filed: July 22, 2002
    Publication date: July 10, 2003
    Inventors: Chandra Vargeese, Jasenka Matulic-Adamic, Alexander Karpeisky, Leonid Beigelman, Lawrence Blatt, Shawn Zinnen
  • Publication number: 20030105308
    Abstract: The present invention relates to novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes or DNAzymes). Also, provided are the use of novel enzymatic nucleic acid molecules to inhibit gene expression and their applications in human therapy.
    Type: Application
    Filed: July 31, 2001
    Publication date: June 5, 2003
    Inventors: Leonid Beigelman, Shawn Zinnen
  • Publication number: 20030065155
    Abstract: Nucleic acid sensor molecules and methods are provided for the detection and amplification of signaling agents using enzymatic nucleic acid constructs, including hammerhead enzymatic nucleic acid molecules, inozymes, G-cleaver enzymatic nucleic acid molecules, zinzymes, amberzymes and DNAzymes. Also provided are kits for detection and amplification. The nucleic acid sensor molecules, methods and kits provided herein can be used in diagnostics, nucleic acid circuits, nucleic acid computers, therapeutics, target validation, target discovery, drug optimization, single nucleotide polymorphism (SNP) detection, single nucleotide polymorphism (SNP) scoring, and proteome scoring as well as other uses described herein.
    Type: Application
    Filed: January 23, 2002
    Publication date: April 3, 2003
    Inventors: Nassim Usman, James A. McSwiggen, Shawn Zinnen, Scott Seiwert, Peter Haeberli, Bharat Chowrira, Lawrence Blatt, Narendra K. Vaish
  • Patent number: 6528640
    Abstract: Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. Also, described are the use of novel enzymatic nucleic acid molecules to inhibit HER2/neu/ErbB2 gene expression and their applications in human therapy.
    Type: Grant
    Filed: December 29, 1999
    Date of Patent: March 4, 2003
    Assignee: Ribozyme Pharmaceuticals, incorporated
    Inventors: Leonid Beigelman, Alex Burgin, Amber Beaudry, Alexander Karpeisky, Jasenka Matulic-Adamic, David Sweedler, Shawn Zinnen
  • Publication number: 20030008295
    Abstract: Nucleic acid sensor molecules and methods are disclosed for the detection and amplification of signaling agents using enzymatic nucleic acid constructs, including hammerhead enzymatic nucleic acid molecules, inozymes, G-cleaver enzymatic nucleic acid molecules, zinzymes, amberzymes and DNAzymes; kits for detection and amplification; use in diagnostics, nucleic acid circuits, nucleic acid computers, therapeutics, target validation, target discovery, drug optimization, SNP detection, SNP scoring, proteome scoring and other uses are disclosed.
    Type: Application
    Filed: November 5, 2001
    Publication date: January 9, 2003
    Inventors: Nassim Usman, James A. McSwiggen, Shawn Zinnen, Scott Seiwert, Peter Haeberli, Bharat Chowrira, Lawrence Blatt, Narendra Vaish
  • Publication number: 20030004122
    Abstract: The present invention relates to novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes or DNAzymes). Also, provided are the use of novel enzymatic nucleic acid molecules to inhibit HER2/neu/ErbB2 gene expression and their applications in human therapy.
    Type: Application
    Filed: April 4, 2001
    Publication date: January 2, 2003
    Inventors: Leonid Beigelman, Alex Burgin, Amber Beaudry, Alexander Karpeisky, Jasenka Matulic-Adamic, David Sweedler, Shawn Zinnen
  • Patent number: 6482932
    Abstract: Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed.
    Type: Grant
    Filed: April 28, 1999
    Date of Patent: November 19, 2002
    Assignee: Ribozyme Pharmaceuticals, Incorporated
    Inventors: Leonid Beigelman, Alex Burgin, Amber Beaudry, Alexander Karpeisky, Jasenka Matulic-Adamic, David Sweedler, Shawn Zinnen
  • Publication number: 20020102568
    Abstract: Nucleic acid sensor molecules and methods are disclosed for the detection and amplification of signaling agents using enzymatic nucleic acid constructs, including hammerhead enzymatic nucleic acid molecules, inozymes, G-cleaver enzymatic nucleic acid molecules, zinzymes, amberzymes and DNAzymes; kits for detection and amplification; use in diagnostics, nucleic acid circuits, nucleic acid computers, therapeutics, target validation, target discovery, drug optimization, SNP detection, SNP scoring, proteome scoring and other uses are disclosed.
    Type: Application
    Filed: June 8, 2001
    Publication date: August 1, 2002
    Inventors: Nassim Usman, James A. McSwiggen, Shawn Zinnen, Scott Seiwert, Peter Haeberli, Bharat Chowrira, Lawrence Blatt, Narendra K. Vaish