Abstract: A system may be provided which comprises an illumination source adapted to simultaneously illuminate a surgical site with spectral light comprising a first wavelength of light and a second wavelength of light, a first set of sensors comprising sensors adapted to detect visible light, and a second set of sensors comprising sensors adapted to detect the first wavelength of light; and sensors adapted to detect the second wavelength of light. In such a case, the system may also comprise a display coupled to a processor configured to display an enhanced image of the surgical site comprising a visible light image from data detected by the first set of sensors and an overlay identifying a target structure based on light detected by the second set of sensors while the surgical site is illuminated by spectral light comprising the first and second wavelengths of light.