Abstract: The present invention is directed to a prosthetic atrioventricular valve (10), suitable for transvascular delivery to a heart valve annulus, comprising a tubular stent-like portion (14) that is continuous in its upper part with a laterally expanded crown-like portion (12), wherein at least said stent-like portion is covered with a covering layer (32) comprising a biocompatible fabric, pericardial tissue or combination thereof, and wherein said stent-like portion is fitted with two or more valve leaflets (36a, 36b). The invention also includes within its scope a cardiac valve support device (18) comprising a tubular stent-like portion that is continuous in its upper part with a laterally expanded crown-like portion.

Abstract: The present invention provides an intracardiac device suitable for minimally-invasive delivery, wherein said device comprises a device body and one more stabilizing elements attached to said device body. The stabilizing elements may be selected from the group consisting of: stabilizing wings having at least one portion with a thickness greater than that of the device body, wings comprising one or more auxiliary support arms, wings having a metal wire coil wound around them, wings having a leaf spring attached thereto, polymer-coated stabilizing wings, and mechanical stabilization elements comprising a rotatable jaw-like structure.

Abstract: Cardiac valve supports and their methods of use.

Abstract: A rapid exchange balloon catheter including: an outer conduit having a lumen and a wall surrounding the lumen, the wall including a lateral opening formed therein; an inner conduit having a proximal end and a distal end; a sealing sleeve for sealing the lateral opening of the outer conduit; a balloon whose proximal margin is attached to the outer surface of the distal end of the outer conduit, and whose distal margin is attached to the outer surface of the portion of the inner conduit that extends beyond the distal end of the outer conduit; a pushing-pulling mechanism disposed in the outer conduit; and a fluid port for the introduction of an expansion fluid and for the removal of the expansion fluid.

Abstract: The present invention is primarily directed to a valve support device suitable for endovascular and/or transapical implantation at or near to a cardiac valve annulus, comprising one or more support rings and one or more height-increasing elements attached to the inner circumference of said support rings. Preferred embodiments of height-increasing elements for use in the present invention include wire springs of various types, fabric sleeves and tab-like elements.

Abstract: The present invention provides an intracardiac device suitable for minimally-invasive delivery, wherein said device comprises a device body and one more stabilizing elements attached to said device body. The stabilizing elements may be selected from the group consisting of: stabilizing wings having at least one portion with a thickness greater than that of the device body, wings comprising one or more auxiliary support arms, wings having a metal wire coil wound around them, wings having a leaf spring attached thereto, polymer-coated stabilizing wings, and mechanical stabilization elements comprising a rotatable jaw-like structure.

Abstract: The present invention provides an intracardiac device (60) suitable for endovascular and/or transapical implantation at a cardiac valve annulus, wherein said device comprises means for reducing paravalvular leakage (PVL), said means being selected from the group consisting of: lateral-edge extensions, one or more tubular sealing elements, one or more barbs, an inferiorly-directed circumferential fabric skirt (68) attached to the inner circumference of the intracardiac device and an inferiorly-directed fabric curtain attached to the outer circumference of said device.

Abstract: A balloon catheter includes an outer conduit having an outer surface, and an inner conduit having an outer surface. The inner conduit is suitable for passage over a guide wire, and the inner conduit is movably disposed within the lumen of the outer conduit. There is also a balloon having a proximal margin and a distal margin, such that the proximal margin of the balloon is attached to the outer surface of the distal tip of the outer conduit and the distal margin of the balloon is attached to the outer surface of the portion of the inner conduit that extends beyond the distal tip of the outer conduit. And there is a fluid port for introducing an expansion fluid into the annular space formed between the inner surface of the outer conduit and the outer surface of the inner conduit and into the lumen of the balloon, and for the removal of the expansion fluid.

Abstract: The present invention provides a body passage cleansing device suitable for being passed through an internal channel of an endoscope, comprising a distal plug having a proximal end and a distal end, wherein said plug comprises channels, apertures and/or nozzles which are capable of allowing the passage of a fluid therethrough from said proximal end to said distal end, wherein said plug is connected to the distal end of a wire or other actuating means; wherein at least an outer portion of said distal plug is capable of being elastically deformed such that the external diameter and/or outline thereof may be reduced in response to inwardly-directed compression forces exerted thereon; and wherein said channels, apertures and/or nozzles are in a closed conformation when said distal plug is subject to said compression forces, and in an open conformation when said plug is not subject to said compression forces.

Abstract: The present invention provides a cardiac valve support device adapted for endovascular delivery to a cardiac valve, wherein said support device comprises either a single support element with valve leaflets connected thereto or two interconnected support elements having valve leaflets connected to one of said two elements. The invention further encompasses a two-stage method for implanting a replacement cardiac valve, wherein the first stage comprises delivering a valve support device fitted with one or more valve leaflets to a location near a subject's cardiac valve, such that said valve leaflets fulfill the function previously fulfilled by the native valve.

Abstract: A rigid head for use in a working channel of an endoscope is provided, the rigid head comprising: a body having a proximal end, a distal end and a longitudinal axis, the body having at least one channel disposed along the longitudinal axis configured to guide fluid in or out of the working channel, wherein the rigid head is configured for disposal within a working channel of an endoscope, the at least one channel configured to guide fluid in and out of the working channel of the endoscope. Body passage devices and methods are provided that allow the guidewire and/or rigid head to be extended in different length endoscope working channels.

Abstract: A balloon catheter includes an outer conduit having an outer surface, and an inner conduit having an outer surface. The inner conduit is suitable for passage over a guide wire, and the inner conduit is movably disposed within the lumen of the outer conduit. There is also a balloon having a proximal margin and a distal margin, such that the proximal margin of the balloon is attached to the outer surface of the distal tip of the outer conduit and the distal margin of the balloon is attached to the outer surface of the portion of the inner conduit that extends beyond the distal tip of the outer conduit. And there is a fluid port for introducing an expansion fluid into the annular space formed between the inner surface of the outer conduit and the outer surface of the inner conduit and into the lumen of the balloon, and for the removal of the expansion fluid.

Abstract: The present device provides a delivery device (10) suitable for delivering a cardiac valve support device (11) that comprises at least one support element (14, 19) and two or more stabilizing elements (16), wherein said delivery device comprises a proximal handle and an outer conduit (12) that is continuous therewith, and wherein said delivery device further comprises various means for controlling the release of said support element from the open distal end of said outer conduit and means for retaining the support device stabilizing elements in a closed conformation, and independently controlling their release.

Abstract: A rapid exchange balloon catheter including: an outer conduit having a lumen and a wall surrounding the lumen, the wall including a lateral opening formed therein; an inner conduit having a proximal end and a distal end; a sealing sleeve for sealing the lateral opening of the outer conduit; a balloon whose proximal margin is attached to the outer surface of the distal end of the outer conduit, and whose distal margin is attached to the outer surface of the portion of the inner conduit that extends beyond the distal end of the outer conduit; a pushing-pulling mechanism disposed in the outer conduit; and a fluid port for the introduction of an expansion fluid and for the removal of the expansion fluid.

Abstract: The present invention is primarily directed a prosthetic cardiac valve support device adapted for endovascular delivery to a cardiac valve, comprising a single ring-shaped support element having an inner diameter and an outer diameter, wherein said support element has an outer perimeter that is entirely rigid, wherein said support element is fitted with one or more intra-ventricular and/or intra-atrial stabilizing elements, and wherein said support element has a collapsed delivery configuration and a deployed configuration.

Abstract: A balloon catheter includes an outer conduit having an outer surface, and an inner conduit having an outer surface. The inner conduit is suitable for passage over a guide wire, and the inner conduit is movably disposed within the lumen of the outer conduit. There is also a balloon having a proximal margin and a distal margin, such that the proximal margin of the balloon is attached to the outer surface of the distal tip of the outer conduit and the distal margin of the balloon is attached to the outer surface of the portion of the inner conduit that extends beyond the distal tip of the outer conduit. And there is a fluid port for introducing an expansion fluid into the annular space formed between the inner surface of the outer conduit and the outer surface of the inner conduit and into the lumen of the balloon, and for the removal of the expansion fluid.

Abstract: The present invention is primarily directed to a rapid exchange catheter that permits axial movement of an inner conduit within an outer conduit comprising: • an outer conduit; • an inner conduit, suitable for total or partial passage over a guide wire, wherein said inner conduit is movably disposed within the lumen of said outer conduit, wherein the proximal end of said inner conduit is angled such that it pierces the wall of said outer conduit; • means for permitting axial movement of said inner conduit within said outer conduit, such that said movement is not hindered by the passage of the angled proximal part of the inner conduit through said outer conduit; and • means, situated at the proximal end of the outer conduit, for causing axial pushing-pulling movements of said inner conduit.

Abstract: An intracardiac device comprising a ring-shaped body and one or more anchoring or stabilizing elements attached to said body, said elements being selected from the group consisting of levered anchoring arms, elongate anchoring arms, and lateral extension elements, wherein said device is able to move between two conformations, a collapsed conformation suitable for insertion into a delivery catheter, and an open conformation, suitable for implantation at a cardiac valve annulus.

Abstract: The present invention may provide devices suitable for insertion into a body passage. The devices may include a conduit and a distal head region located at the distal end of said conduit. A plurality of apertures on the surface of said head region and conduit may be used to direct a liquid spray outwards from said device. The apertures may be designed and spatially arranged such that when the device is inserted into a body passage, the liquid spray emitted from said apertures may be capable of both reducing the frictional contact between the device and the walls of said passage and of cleansing said passage of undesired solid and other particulate matter.

Abstract: The present invention is primarily directed towards an anatomically-compatible and physiologically-compatible in vivo device for improving diastolic function of either the left or right ventricle of the heart, wherein said device comprises at least one elastic component in the form of a lattice capable of being arranged in a curved conformation such that one surface of said lattice may be adapted to the curvature of the external ventricular surface of the heart, or a portion thereof, and wherein said at least one elastic component is capable of being operatively connected to the external ventricular surface of the heart by means of one or more connecting elements.