Patents by Inventor Shayna K. Rockow-Magnone

Shayna K. Rockow-Magnone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antisense oligonucleotides of the human chk1 gene and uses thereof
    Patent number: 6211164
    Abstract: The subject invention relates to antisense oligonucleotides of the human Chk1 gene and to uses thereof. The human ChK1 gene is a major G2/M checkpoint gene that is activated in response to DNA damage. In particular, the gene transduces the inhibitory signal from DNA damage sensors to the basic cell cycle machinery. Thus, antisense oligonucleotides to the human Chk1 gene may be used, for example, to inhibit the gene thereby preventing G2 arrest induced by DNA damaging agents. Such antisense oligonucleotides should also further sensitize tumor cells thereby making them more sensitive to therapy than normal cells.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: April 3, 2001
    Assignee: Abbott Laboratories
    Inventors: Yan Luo, Vincent L. Giranda, Shayna K. Rockow-Magnone