Patents by Inventor Shaza Mohamed Adel Al-Massarani
Shaza Mohamed Adel Al-Massarani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10954264Abstract: The synthesis of ursolic acid nanoparticles includes dissolving ursolic acid powder in methanol, boiling water for five minutes, and adding the methanol solution to the boiled water dropwise at a flow rate of 0.1-0.3 ml/min under ultrasonic conditions. After sonication for 20 minutes, the contents are stirred for about 15 minutes, and then dried. Particle size distribution studies and TEM micrographs confirm the resulting product comprises nanoparticles. In vitro testing confirms the ursolic acid nanoparticles exhibit greater anticancer activity than conventional-size particles, and that the nanoparticles exhibit antimicrobial effect against gram positive and gram negative bacteria, as well as fungi.Type: GrantFiled: August 27, 2019Date of Patent: March 23, 2021Assignee: KING SAUD UNIVERSITYInventors: Rabab Abd El Moneim Khalil El Dib, Shaza Mohamed Adel Al-Massarani, Manal Ahmed Gasmelseed Awad, Ali Ali Hasan Elgamal
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Patent number: 10947265Abstract: The synthesis of ursolic acid nanoparticles includes dissolving ursolic acid powder in methanol, boiling water for five minutes, and adding the methanol solution to the boiled water dropwise at a flow rate of 0.1-0.3 ml/min under ultrasonic conditions. After sonication for 20 minutes, the contents are stirred for about 15 minutes, and then dried. Particle size distribution studies and TEM micrographs confirm the resulting product comprises nanoparticles. In vitro testing confirms the ursolic acid nanoparticles exhibit greater anticancer activity than conventional-size particles, and that the nanoparticles exhibit antimicrobial effect against gram positive and gram negative bacteria, as well as fungi.Type: GrantFiled: August 27, 2019Date of Patent: March 16, 2021Assignee: KING SAUD UNIVERSITYInventors: Rabab Abd El Moneim Khalil El Dib, Shaza Mohamed Adel Al-Massarani, Manal Ahmed Gasmelseed Awad, Ali Ali Hasan Elgamal
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Patent number: 10947266Abstract: The synthesis of ursolic acid nanoparticles includes dissolving ursolic acid powder in methanol, boiling water for five minutes, and adding the methanol solution to the boiled water dropwise at a flow rate of 0.1-0.3 ml/min under ultrasonic conditions. After sonication for 20 minutes, the contents are stirred for about 15 minutes, and then dried. Particle size distribution studies and TEM micrographs confirm the resulting product comprises nanoparticles. In vitro testing confirms the ursolic acid nanoparticles exhibit greater anticancer activity than conventional-size particles, and that the nanoparticles exhibit antimicrobial effect against gram positive and gram negative bacteria, as well as fungi.Type: GrantFiled: August 27, 2019Date of Patent: March 16, 2021Assignee: KING SAUD UNIVERSITYInventors: Rabab Abd El Moneim Khalil El Dib, Shaza Mohamed Adel Al-Massarani, Manal Ahmed Gasmelseed Awad, Ali Ali Hasan Elgamal
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Publication number: 20200165294Abstract: The synthesis of ursolic acid nanoparticles includes dissolving ursolic acid powder in methanol, boiling water for five minutes, and adding the methanol solution to the boiled water dropwise at a flow rate of 0.1-0.3 ml/min under ultrasonic conditions. After sonication for 20 minutes, the contents are stirred for about 15 minutes, and then dried. Particle size distribution studies and TEM micrographs confirm the resulting product comprises nanoparticles. In vitro testing confirms the ursolic acid nanoparticles exhibit greater anticancer activity than conventional-size particles, and that the nanoparticles exhibit antimicrobial effect against gram positive and gram negative bacteria, as well as fungi.Type: ApplicationFiled: August 27, 2019Publication date: May 28, 2020Inventors: RABAB ABD EL MONEIM KHALIL EL DIB, SHAZA MOHAMED ADEL AL-MASSARANI, MANAL AHMED GASMELSEED AWAD, ALI ALI HASAN ELGAMAL
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Publication number: 20200165293Abstract: The synthesis of ursolic acid nanoparticles includes dissolving ursolic acid powder in methanol, boiling water for five minutes, and adding the methanol solution to the boiled water dropwise at a flow rate of 0.1-0.3 ml/min under ultrasonic conditions. After sonication for 20 minutes, the contents are stirred for about 15 minutes, and then dried. Particle size distribution studies and TEM micrographs confirm the resulting product comprises nanoparticles. In vitro testing confirms the ursolic acid nanoparticles exhibit greater anticancer activity than conventional-size particles, and that the nanoparticles exhibit antimicrobial effect against gram positive and gram negative bacteria, as well as fungi.Type: ApplicationFiled: August 27, 2019Publication date: May 28, 2020Inventors: RABAB ABD EL MONEIM KHALIL EL DIB, SHAZA MOHAMED ADEL AL-MASSARANI, MANAL AHMED GASMELSEED AWAD, ALI ALI HASAN ELGAMAL
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Publication number: 20200165292Abstract: The synthesis of ursolic acid nanoparticles includes dissolving ursolic acid powder in methanol, boiling water for five minutes, and adding the methanol solution to the boiled water dropwise at a flow rate of 0.1-0.3 ml/min under ultrasonic conditions. After sonication for 20 minutes, the contents are stirred for about 15 minutes, and then dried. Particle size distribution studies and TEM micrographs confirm the resulting product comprises nanoparticles. In vitro testing confirms the ursolic acid nanoparticles exhibit greater anticancer activity than conventional-size particles, and that the nanoparticles exhibit antimicrobial effect against gram positive and gram negative bacteria, as well as fungi.Type: ApplicationFiled: August 27, 2019Publication date: May 28, 2020Inventors: RABAB ABD EL MONEIM KHALIL EL DIB, SHAZA MOHAMED ADEL AL-MASSARANI, MANAL AHMED GASMELSEED AWAD, ALI ALI HASAN ELGAMAL
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Patent number: 10442833Abstract: The synthesis of ursolic acid nanoparticles includes dissolving ursolic acid powder in methanol, boiling water for five minutes, and adding the methanol solution to the boiled water dropwise at a flow rate of 0.1-0.3 ml/min under ultrasonic conditions. After sonication for 20 minutes, the contents are stirred for about 15 minutes, and then dried. Particle size distribution studies and TEM micrographs confirm the resulting product comprises nanoparticles. In vitro testing confirms the ursolic acid nanoparticles exhibit greater anticancer activity than conventional-size particles, and that the nanoparticles exhibit antimicrobial effect against gram positive and gram negative bacteria, as well as fungi.Type: GrantFiled: November 27, 2018Date of Patent: October 15, 2019Assignee: King Saud UniversityInventors: Rabab Abd El Moneim Khalil El Dib, Shaza Mohamed Adel Al-Massarani, Manal Ahmed Gasmelseed Awad, Ali Ali Hasan El Gamal
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Patent number: 10278999Abstract: In one embodiment, synthesis of Nuxia oppositifolia nanoparticles includes providing a Nuxia oppositifolia powder; dissolving the powder in a first alcohol to provide a first alcohol extract; concentrating a filtrate from the first alcohol extract under reduced pressure to provide a dried alcohol extract; dissolving the dried alcohol extract in the first alcohol to provide a second alcohol extract; successively partitioning the second alcohol extract using n-hexane to provide an n-hexane extract; dissolving the n-hexane extract in a second alcohol and water to provide a first solution; and adding an acidic solution to the first solution to form a final solution including Nuxia oppositifolia nanoparticles.Type: GrantFiled: November 29, 2017Date of Patent: May 7, 2019Assignee: King Saud UniversityInventors: Ali Ali El-Gamal, Adnan Jathlan Al-Rehaily, Manal Ahmed Gasmelseed Awad, Rabab Abd El Moneim Khalil El Dib, Shaza Mohamed Adel Al-Massarani
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Patent number: 10202415Abstract: A method for synthesizing 3-oxolupenal nanoparticles including isolating 3-oxolupenal from a fraction of Nuxia oppositifolia plant, reducing the 3-oxolupenal to obtain a powder of 3-oxolupenal, dissolving the powder of 3-oxolupenal in methanol to form a first solution, adding the first solution to boiling water to form a second solution, sonicating the second solution, and freeze-drying after sonication to obtain the synthesized 3-oxolupenal nanoparticles. The synthesized 3-oxolupenal nanoparticles exhibited cytotoxic effects and antimicrobial effects.Type: GrantFiled: October 19, 2017Date of Patent: February 12, 2019Assignee: King Saud UniversityInventors: Rabab Abd El Moneim Khalil El Dib, Shaza Mohamed Adel Al-Massarani, Manal Ahmed Gasmelseed Awad, Ali Ali El-Gamal
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Publication number: 20180344789Abstract: In one embodiment, synthesis of Nuxia oppositifolia nanoparticles includes providing a Nuxia oppositifolia powder; dissolving the powder in a first alcohol to provide a first alcohol extract; concentrating a filtrate from the first alcohol extract under reduced pressure to provide a dried alcohol extract; dissolving the dried alcohol extract in the first alcohol to provide a second alcohol extract; successively partitioning the second alcohol extract using n-hexane to provide an n-hexane extract; dissolving the n-hexane extract in a second alcohol and water to provide a first solution; and adding an acidic solution to the first solution to form a final solution including Nuxia oppositifolia nanoparticles.Type: ApplicationFiled: November 29, 2017Publication date: December 6, 2018Inventors: ALI ALI EL-GAMAL, ADNAN JATHLAN AL-REHAILY, MANAL AHMED GASMELSEED AWAD, RABAB ABD EL MONEIM KHALIL EL DIB, SHAZA MOHAMED ADEL AL-MASSARANI
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Patent number: 10086027Abstract: The synthesis of katononic acid nanosheets is a method of extraction of katononic acid from the n-hexane fraction of Nuxia oppositifolia. The katononic acid isolated from N. oppositifolia may be suspended in methanol and added dropwise to boiling water, sonicated, stirred, and freeze dried to form katononic acid nanosheets. These katononic acid nanosheets may be used to kill cancer cells or microorganisms.Type: GrantFiled: March 1, 2018Date of Patent: October 2, 2018Assignee: KING SAUD UNIVERSITYInventors: Ali Ali Hassan Elgamal, Manal Ahmed Gasmelseed Awad, Rabab El Dib, Shaza Mohamed Adel Al-Massarani, Omer Ahmed Basudan
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Patent number: 10028988Abstract: Synthesis of Nuxia oppositifolia nanoparticles includes providing an extract of Nuxia oppositifolia, dissolving the extract in alcohol to provide a mixture, adding water to the mixture to provide an aqueous solution, adding an acidic solution to the aqueous solution to form a final solution including Nuxia oppositifolia nanoparticles; and centrifuging the final solution to isolate the Nuxia oppositifolia nanoparticles.Type: GrantFiled: June 1, 2017Date of Patent: July 24, 2018Assignee: KING SAUD UNIVESITYInventors: Manal Ahmed Gasmelseed Awad, Rabab Abd El Moneim Khalil El Dib, Shaza Mohamed Adel Al-Massarani, Ali Ali El-Gamal
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Patent number: 9974750Abstract: Synthesis of ifflaionic acid nanoparticles includes dissolving a powder of ifflaionic acid in an alcohol solution to form a first solution, adding the first solution to an aqueous solution under ultrasonic conditions to produce a sonicated solution, stirring the sonicated solution for a duration of time to produce a mixture, and freeze-drying the mixture to provide the ifflaionic acid nanoparticles.Type: GrantFiled: October 16, 2017Date of Patent: May 22, 2018Assignee: KING SAUD UNIVERSITYInventors: Shaza Mohamed Adel Al-Massarani, Rabab Abd El Moneim Khalil El Dib, Ali Ali El-Gamal, Manal Ahmed Gasmelseed
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Patent number: 9889170Abstract: A method of preparing nanoparticles from desert date can include providing a metal salt solution comprising metal ions; providing desert date extract solution that comprises a reducing agent, and combining the metal ion solution and the desert date extract solution while stirring at a temperature in the range of 25° C. to 100° C. to produce metal or metal oxide nanoparticles. The metal nanoparticles can be gold nanoparticles. The metal oxide nanoparticles can be zinc oxide nanoparticles. The nanoparticles can be used to inhibit the growth or proliferation of a cancer cell and/or microorganisms.Type: GrantFiled: October 6, 2016Date of Patent: February 13, 2018Assignee: KING SAUD UNIVERSITYInventors: Manal Ahmed Gasmelseed Awad, Rabab Abd El Moneim Khalil El Dib, Awatif Ahmed Hendi, Shaza Mohamed Adel Al-Massarani, Khalid Mustafa Osman Ortashi