Patents by Inventor Sheela A. Thomas

Sheela A. Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS
    Publication number: 20140296235
    Abstract: Compounds having formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).
    Type: Application
    Filed: April 11, 2014
    Publication date: October 2, 2014
    Inventors: Thomas D. Penning, Sheela A. Thomas, Gui-Dong Zhu, Virajkumar B. Gandhi, Jianchun Gong, Vincent L. Giranda
  • 1H-benzimidazole-4-carboxamides substituted with phenyl at the 2-position are potent PARP inhibitors
    Patent number: 8697736
    Abstract: Compound having formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: April 15, 2014
    Assignee: AbbVie Inc.
    Inventors: Thomas D. Penning, Sheela A. Thomas, Gui-Dong Zhu, Virajkumar B. Gandhi, Jianchun Gong, Vincent L. Giranda
  • 2-substituted-1H-benzimidazole-4-carboxamides are PARP inhibitors
    Patent number: 8217070
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: July 10, 2012
    Assignee: Abbott Laboratories
    Inventors: Gui-Dong Zhu, Virajkumar B. Gandhi, Jianchun Gong, Thomas D. Penning, Vincent L. Giranda, Sheela Thomas
  • Potent PARP inhibitors
    Patent number: 8183250
    Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: May 22, 2012
    Assignee: Abbott Laboratories
    Inventors: Thomas D. Penning, Sheela A. Thomas, Philip J. Hajduk, Daryl R. Sauer, Kathy Sarris, Vincent L. Giranda
  • Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors
    Patent number: 7999117
    Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: August 16, 2011
    Inventors: Vincent L. Giranda, Thomas D. Penning, Virajkumar B. Gandhi, Sheela A. Thomas, Gui-Dong Zhu, Jianchun Gong
  • Biaryl carboxylic acid apoptosis promoters
    Patent number: 7989656
    Abstract: The present invention relates to biaryl carboxylic acid compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing these compounds and methods of treating diseases which express the Mcl-1 protein.
    Type: Grant
    Filed: May 25, 2010
    Date of Patent: August 2, 2011
    Assignee: Abbott Laboratories
    Inventors: Michael D. Wendt, Hong Ding, Sheela A. Thomas, Steven W. Elmore, Wang Shen, Daniel A. Dickman, David Augeri
  • 2-SUBSTITUTED-1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE PARP INHIBITORS
    Publication number: 20100234425
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Application
    Filed: April 22, 2010
    Publication date: September 16, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Gui-Dong Zhu, Virajkumar B. Gandhi, Jianchun Gong, Thomas D. Penning, Vincent L. Giranda, Sheela Thomas
  • APOPTOSIS PROMOTERS
    Publication number: 20100234456
    Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl-1 protein are disclosed.
    Type: Application
    Filed: May 25, 2010
    Publication date: September 16, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Michael D. Wendt, Hong Ding, Sheela A. Thomas, Steven W. Elmore, Wang Shen, Daniel A. Dickman, David Augeri
  • N-acylsulfonamide apoptosis promoters
    Patent number: 7754886
    Abstract: N-Benzoyl arylsulfonamides having the formula are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.
    Type: Grant
    Filed: February 3, 2009
    Date of Patent: July 13, 2010
    Assignee: Abbott Laboratories
    Inventors: David J. Augeri, Steven A. Baumeister, Milan Bruncko, Daniel A. Dickman, Hong Ding, Jurgen Dinges, Stephen W. Fesik, Philip J Hajduk, Aaron R Kunzer, William J. Mcclellan, David D. Nettesheim, Thorsten K. Oost, Andrew M. Petros, Saul Howard Rosenberg, Wang Shen, Sheela A. Thomas, Xilu Wang, Michael D. Wendt
  • Apoptosis promoters
    Patent number: 7750004
    Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl-1 protein are disclosed.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: July 6, 2010
    Assignee: Abbott Laboratories
    Inventors: Michael D. Wendt, Hong Ding, Sheela A. Thomas, Steven W. Elmore, Wang Shen, Daniel A. Dickman, David Augeri
  • 2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors
    Patent number: 7728026
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), method of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compound of Formula (I).
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: June 1, 2010
    Assignee: Abbott Laboratories, Inc.
    Inventors: Gui-Dong Zhu, Virajkumar B. Gandhi, Jianchun Gong, Thomas D. Penning, Vincent L. Giranda, Sheela Thomas
  • POTENT PARP INHIBITORS
    Publication number: 20090298858
    Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
    Type: Application
    Filed: June 2, 2009
    Publication date: December 3, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Thomas D. Penning, Sheela A. Thomas, Philip J. Hajduk, Daryl R. Sauer, Kathy Sarris, Vincent L. Giranda
  • Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors
    Patent number: 7595406
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Grant
    Filed: July 30, 2007
    Date of Patent: September 29, 2009
    Assignee: Abbott Laboratories Inc.
    Inventors: Thomas D. Penning, Sheela A. Thomas, Gui-Dong Zhu, Jianchun Gong, Vincent L. Giranda, Viraj B. Gandhi
  • SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS
    Publication number: 20090186877
    Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
    Type: Application
    Filed: March 30, 2009
    Publication date: July 23, 2009
    Applicant: Abbott Laboratories
    Inventors: Vincent L. Giranda, Thomas D. Penning, Virajkumar B. Gandhi, Sheela A. Thomas, Gui-Dong Zhu, Jianchun Gong
  • N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS
    Publication number: 20090137585
    Abstract: N-Benzoyl arylsulfonamides having the formula are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.
    Type: Application
    Filed: February 3, 2009
    Publication date: May 28, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: David J. Augeri, Steven A. Baumeister, Milan Bruncko, Daniel A. Dickman, Hong Ding, Jurgen Dinges, Stephen W. Fesik, Philip J. Hajduk, Aaron R. Kunzer, William Mcclellan, David G. Nettesheim, Thorsten Oost, Andrew M. Petros, Saul H. Rosenberg, Wang Shen, Sheela A. Thomas, Xilu Wang, Michael D. Wendt
  • N-acylsulfonamide apoptosis promoters
    Patent number: 7504512
    Abstract: N-Benzoyl arylsulfonamides having the formula are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: March 17, 2009
    Assignee: Abbott Laboratories
    Inventors: David J. Augeri, Steven A. Baumeister, Milan Bruncko, Daniel A. Dickman, Hong Ding, Jurgen Dinges, Stephen W. Fesik, Philip J. Hajduk, Aaron R. Kunzer, William McClellan, David G. Nettesheim, Thorsten Oost, Andrew M. Petros, Saul H. Rosenberg, Wang Shen, Sheela A. Thomas, Xilu Wang, Michael D. Wendt
  • Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors
    Patent number: 7462724
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: December 9, 2008
    Assignee: Abbott Laboratories
    Inventors: Thomas D. Penning, Sheela A. Thomas, Gui-Dong Zhu, Jianchun Gong, Vincent L. Giranda, Viraj B. Gandhi
  • PIM KINASE INHIBITORS AS CANCER CHEMOTHERAPEUTICS
    Publication number: 20080161578
    Abstract: Inhibitors of Pim kinases, ways to make them and methods of treating patients using them are disclosed.
    Type: Application
    Filed: December 6, 2007
    Publication date: July 3, 2008
    Applicant: ABBOTT LABORATORIES
    Inventors: Thomas D. Penning, Sheela A. Thomas, Vincent L. Giranda
  • Potent PARP Inhibitors
    Publication number: 20080015182
    Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
    Type: Application
    Filed: June 20, 2007
    Publication date: January 17, 2008
    Inventors: Thomas Penning, Sheela Thomas, Philip Hajduk, Daryl Sauer, Kathy Sarris, Vincent Giranda
  • SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS
    Publication number: 20070270476
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Application
    Filed: July 30, 2007
    Publication date: November 22, 2007
    Inventors: Thomas Penning, Sheela Thomas, Gui-Dong Zhu, Jianchun Gong, Vincent Giranda, Viraj Gandhi