Patents by Inventor Sheela Thomas

Sheela Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-substituted-1H-benzimidazole-4-carboxamides are PARP inhibitors
    Patent number: 8217070
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: July 10, 2012
    Assignee: Abbott Laboratories
    Inventors: Gui-Dong Zhu, Virajkumar B. Gandhi, Jianchun Gong, Thomas D. Penning, Vincent L. Giranda, Sheela Thomas
  • 2-SUBSTITUTED-1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE PARP INHIBITORS
    Publication number: 20100234425
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Application
    Filed: April 22, 2010
    Publication date: September 16, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Gui-Dong Zhu, Virajkumar B. Gandhi, Jianchun Gong, Thomas D. Penning, Vincent L. Giranda, Sheela Thomas
  • 2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors
    Patent number: 7728026
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), method of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compound of Formula (I).
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: June 1, 2010
    Assignee: Abbott Laboratories, Inc.
    Inventors: Gui-Dong Zhu, Virajkumar B. Gandhi, Jianchun Gong, Thomas D. Penning, Vincent L. Giranda, Sheela Thomas
  • Potent PARP Inhibitors
    Publication number: 20080015182
    Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
    Type: Application
    Filed: June 20, 2007
    Publication date: January 17, 2008
    Inventors: Thomas Penning, Sheela Thomas, Philip Hajduk, Daryl Sauer, Kathy Sarris, Vincent Giranda
  • SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS
    Publication number: 20070270476
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Application
    Filed: July 30, 2007
    Publication date: November 22, 2007
    Inventors: Thomas Penning, Sheela Thomas, Gui-Dong Zhu, Jianchun Gong, Vincent Giranda, Viraj Gandhi
  • 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS
    Publication number: 20070179136
    Abstract: Compound having formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).
    Type: Application
    Filed: September 29, 2006
    Publication date: August 2, 2007
    Inventors: Thomas Penning, Sheela Thomas, Gui-Dong Zhu, Virajkumar Gandhi, Jianchun Gong, Vincent Giranda
  • Apoptosis promoters
    Publication number: 20070135392
    Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl-1 protein are disclosed.
    Type: Application
    Filed: July 7, 2006
    Publication date: June 14, 2007
    Inventors: Michael Wendt, Hong Ding, Sheela Thomas, Steven Elmore, Wang Shen, Daniel Dickman, David Augeri
  • SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS
    Publication number: 20070112047
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Application
    Filed: November 15, 2006
    Publication date: May 17, 2007
    Inventors: Thomas Penning, Sheela Thomas, Gui-Dong Zhu, Jianchun Gong, Vincent Giranda, Viraj Gandhi
  • 2-Substituted-1 H-benzimidazile-4-carboxamides are PARP inhibitors
    Publication number: 20060229351
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), method of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compound of Formula (I).
    Type: Application
    Filed: April 11, 2006
    Publication date: October 12, 2006
    Inventors: Gui-Dong Zhu, Virajkumar Gandhi, Jianchun Gong, Thomas Penning, Vincent Giranda, Sheela Thomas