Patents by Inventor Sheetal Bhardwaj
Sheetal Bhardwaj has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11332391Abstract: A method, device, and system for removing a volatile component from a liquid solution for a chromatographic separation are described. The method includes the flowing of a liquid solution through a first chamber of the device. A volatile component in the liquid solution is transported across a first ion exchange barrier from the first chamber to a second chamber. The first ion exchange barrier has a first charge. The second chamber includes an ion exchange packing having a second charge that is an opposite polarity to the first charge. The volatile component reacts with the ion exchange packing to create a charged component in the second chamber. The charged component having a third charge that is a same polarity to the first charge. The ion exchange packing is regenerated by electrolytically generating a hydronium or a hydroxide.Type: GrantFiled: April 26, 2019Date of Patent: May 17, 2022Assignee: DIONEX CORPORATIONInventors: Kannan Srinivasan, Sheetal Bhardwaj
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Patent number: 11243194Abstract: A suppressor for use in reducing a background signal while detecting analytes in a liquid sample for ion chromatography is described. The suppressor includes a central channel and two flanking regenerant channels. The central channel is formed with an eluent channel plate including a central cutout portion having a peripheral boundary portion. The peripheral boundary portion includes a recessed eluent plate height that is less than the eluent plate height. The peripheral boundary portion includes two or more notches or protrusions. An eluent screen is disposed in the central cutout portion, in which a peripheral border of the eluent screen has two or more corresponding notches or corresponding protrusions to the eluent channel plate.Type: GrantFiled: January 25, 2019Date of Patent: February 8, 2022Assignee: Dionex CorporationInventors: Kannan Srinivasan, Sheetal Bhardwaj, Glenn M. Kuse
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Patent number: 11090606Abstract: An electrolytic device, e.g. a suppressor, including at least two flow-through channels separated by a charged membrane barrier, and a catalyst, for combining hydrogen and oxygen gas, together with ion exchange material, disposed in one of the channels. Also, a method for simultaneous electrolysis and catalytic gas elimination in a channel of the device is described.Type: GrantFiled: December 5, 2013Date of Patent: August 17, 2021Assignee: Dionex CorporationInventors: Kannan Srinivasan, Sheetal Bhardwaj, Rong Lin
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Publication number: 20200240968Abstract: A suppressor for use in reducing a background signal while detecting analytes in a liquid sample for ion chromatography is described. The suppressor includes a central channel and two flanking regenerant channels. The central channel is formed with an eluent channel plate including a central cutout portion having a peripheral boundary portion. The peripheral boundary portion includes a recessed eluent plate height that is less than the eluent plate height. The peripheral boundary portion includes two or more notches or protrusions. An eluent screen is disposed in the central cutout portion, in which a peripheral border of the eluent screen has two or more corresponding notches or corresponding protrusions to the eluent channel plate.Type: ApplicationFiled: January 25, 2019Publication date: July 30, 2020Inventors: Kannan SRINIVASAN, Sheetal BHARDWAJ, Glenn M. KUSE
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Patent number: 10571439Abstract: An apparatus for detecting analytes in a liquid sample may include an elongated primary channel through which an ionic species flows, the primary channel extending through a primary channel member, a first regenerant channel through which a regenerant flows, the first regenerant channel extending adjacent to the primary channel and being formed in a first block, a first charged barrier having exchangeable ions capable of passing ions of only one charge, positive or negative, and of blocking bulk liquid flow, the first charged barrier disposed between the primary channel member and the first block for separating the primary channel from the first regenerant channel, and a first sealing member disposed between the first charged barrier and the first block defining the first regenerant channel.Type: GrantFiled: July 16, 2018Date of Patent: February 25, 2020Assignee: DIONEX CORPORATIONInventors: Kannan Srinivasan, Glenn M. Kuse, Rong Lin, Sheetal Bhardwaj
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Publication number: 20190322547Abstract: A method, device, and system for removing a volatile component from a liquid solution for a chromatographic separation are described. The method includes the flowing of a liquid solution through a first chamber of the device. A volatile component in the liquid solution is transported across a first ion exchange barrier from the first chamber to a second chamber. The first ion exchange barrier has a first charge. The second chamber includes an ion exchange packing having a second charge that is an opposite polarity to the first charge. The volatile component reacts with the ion exchange packing to create a charged component in the second chamber. The charged component having a third charge that is a same polarity to the first charge. The ion exchange packing is regenerated by electrolytically generating a hydronium or a hydroxide.Type: ApplicationFiled: April 26, 2019Publication date: October 24, 2019Inventors: Kannan SRINIVASAN, Sheetal BHARDWAJ
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Patent number: 10241070Abstract: An electrolytic device includes four channels separated by three charged barriers. The device can be used to suppress an eluent stream containing separated sample analyte ions and/or to pretreat a sample stream containing unseparated analyte ions.Type: GrantFiled: April 23, 2018Date of Patent: March 26, 2019Assignee: DIONEX CORPORATIONInventors: Kannan Srinivasan, Sheetal Bhardwaj, Rong Lin
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Publication number: 20180321197Abstract: An apparatus for detecting analytes in a liquid sample may include an elongated primary channel through which an ionic species flows, the primary channel extending through a primary channel member, a first regenerant channel through which a regenerant flows, the first regenerant channel extending adjacent to the primary channel and being formed in a first block, a first charged barrier having exchangeable ions capable of passing ions of only one charge, positive or negative, and of blocking bulk liquid flow, the first charged barrier disposed between the primary channel member and the first block for separating the primary channel from the first regenerant channel, and a first sealing member disposed between the first charged barrier and the first block defining the first regenerant channel.Type: ApplicationFiled: July 16, 2018Publication date: November 8, 2018Inventors: Kannan SRINIVASAN, Glenn M. KUSE, Rong LIN, Sheetal BHARDWAJ
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Publication number: 20180238825Abstract: An electrolytic device includes four channels separated by three charged barriers. The device can be used to suppress an eluent stream containing separated sample analyte ions and/or to pretreat a sample stream containing unseparated analyte ions.Type: ApplicationFiled: April 23, 2018Publication date: August 23, 2018Inventors: Kannan SRINIVASAN, Sheetal BHARDWAJ, Rong LIN
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Patent number: 10048233Abstract: An apparatus for detecting analytes in a liquid sample may include an elongated primary channel through which an ionic species flows, the primary channel extending through a primary channel member, a first regenerant channel through which a regenerant flows, the first regenerant channel extending adjacent to the primary channel and being formed in a first block, a first charged barrier having exchangeable ions capable of passing ions of only one charge, positive or negative, and of blocking bulk liquid flow, the first charged barrier disposed between the primary channel member and the first block for separating the primary channel from the first regenerant channel, and a first sealing member disposed between the first charged barrier and the first block defining the first regenerant channel.Type: GrantFiled: November 12, 2012Date of Patent: August 14, 2018Assignee: DIONEX CORPORATIONInventors: Kannan Srinivasan, Glenn M. Kuse, Rong Lin, Sheetal Bhardwaj
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Patent number: 9964510Abstract: An electrolytic device includes four channels separated by three charged barriers. The device can be used to suppress an eluent stream containing separated sample analyte ions and/or to pretreat a sample stream containing unseparated analyte ions.Type: GrantFiled: September 16, 2013Date of Patent: May 8, 2018Assignee: DIONEX CORPORATIONInventors: Kannan Srinivasan, Sheetal Bhardwaj, Rong Lin
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Patent number: 9914651Abstract: A sandwich suppressor in an ion chromatography system in which loosely packed ion exchange resin of low density is disposed in the central sample stream flow channel. Also, a method of using the suppressor is described.Type: GrantFiled: May 8, 2013Date of Patent: March 13, 2018Assignee: DIONEX CORPORATIONInventors: Kannan Srinivasan, Christopher A. Pohl, Sheetal Bhardwaj, Rong Lin
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Patent number: 9625430Abstract: An electrolytic device comprising: a central sample flow channel, first and second regenerant flow channels, first and second charged barriers disposed between said sample flow channel and first and second regenerant flow channels, and pairs of oppositely charged, spaced electrodes disposed in the regenerant flow channels. Also, electrolytic devices with a different electrode configuration are described. Also, methods of using the devices, e.g., for suppression in an ion chromatography system are described.Type: GrantFiled: October 18, 2013Date of Patent: April 18, 2017Assignee: DIONEX CORPORATIONInventors: Kannan Srinivasan, Sheetal Bhardwaj, Rong Lin
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Publication number: 20160137530Abstract: A method, device, and system for removing a volatile component from a liquid solution for a chromatographic separation are described. The method includes the flowing of a liquid solution through a first chamber of the device. A volatile component in the liquid solution is transported across a first ion exchange barrier from the first chamber to a second chamber. The first ion exchange barrier has a first charge. The second chamber includes an ion exchange packing having a second charge that is an opposite polarity to the first charge. The volatile component reacts with the ion exchange packing to create a charged component in the second chamber. The charged component having a third charge that is a same polarity to the first charge. The ion exchange packing is regenerated by electrolytically generating a hydronium or a hydroxide.Type: ApplicationFiled: November 13, 2014Publication date: May 19, 2016Inventors: Kannan SRINIVASAN, Sheetal BHARDWAJ
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Patent number: 9322815Abstract: Ion chromatography apparatus including (a) a chromatographic column, (b) a source of an aqueous eluent liquid stream, (c) a detector, (d) a recycle line between the detector and the chromatographic column, and (e) a purifying device disposed along the recycle line including ion exchange removal medium. Also, such apparatus with an electrolytic purifying device disposed along the recycle line. Also, methods of using such apparatus.Type: GrantFiled: February 25, 2008Date of Patent: April 26, 2016Assignee: DIONEX CORPORATIONInventors: Kannan Srinivasan, Rong Lin, Sheetal Bhardwaj, Christopher A. Pohl
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Patent number: 9132364Abstract: The present invention provides a new design for high capacity stationary phases for chromatography, for example, ion chromatography. The stationary phases include a first polymer layer in contact with and at least partially coating the substrate of the stationary phase. The first polymer layer serves as a foundation for the attachment, and in various embodiments, the growth and attachment, of a highly hyperbranched polymer structure, typically based on one or more products of condensation polymerization. Multiple components are of use in forming the first polymer layer and the hyperbranched polymer structure, thereby providing a stationary phase that can be engineered to have a desired property such as ion capacity, ion selectivity, and the like. Exemplary condensation polymers are formed by the reaction of at least one polyfunctional compound with at least one compound of complimentary reactivity, e.g., a nucleophilic polyfunctional compound reacting with an electrophilic compound.Type: GrantFiled: February 26, 2010Date of Patent: September 15, 2015Assignee: Dionex CorporationInventors: Kannan Srinivasan, Christopher A. Pohl, Sheetal Bhardwaj, Rong Lin
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Publication number: 20150157976Abstract: An electrolytic device, e.g. a suppressor, including at least two flow-through channels separated by a charged membrane barrier, and a catalyst, for combining hydrogen and oxygen gas, together with ion exchange material, disposed in one of the channels. Also, a method for simultaneous electrolysis and catalytic gas elimination in a channel of the device is described.Type: ApplicationFiled: December 5, 2013Publication date: June 11, 2015Applicant: DIONEX CORPORATIONInventors: Kannan SRINIVASAN, Sheetal BHARDWAJ, Rong LIN
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Patent number: 9034447Abstract: The present invention provides a new design for high capacity stationary phases for dianion selective ion chromatography. The stationary phases include one or more layers which are products of condensation polymerization. Multiple components are of use in forming the first polymer layer and the condensation polymer structure, thereby providing a stationary phase that can be engineered to have a desired property such as ion capacity, ion selectivity, and the like. Exemplary condensation polymers are formed by the reaction of at least one polyfunctional compound with at least one compound of complimentary reactivity, e.g., a nucleophilic polyfunctional compound reacting with an electrophilic compound.Type: GrantFiled: March 9, 2012Date of Patent: May 19, 2015Assignee: DIONEX CORPORATIONInventors: Christopher A. Pohl, Kannan Srinivasan, Sheetal Bhardwaj
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Publication number: 20150111305Abstract: An electrolytic device comprising: a central sample flow channel, first and second regenerant flow channels, first and second charged barriers disposed between said sample flow channel and first and second regenerant flow channels, and pairs of oppositely charged, spaced electrodes disposed in the regenerant flow channels. Also, electrolytic devices with a different electrode configuration are described. Also, methods of using the devices, e.g., for suppression in an ion chromatography system are described.Type: ApplicationFiled: October 18, 2013Publication date: April 23, 2015Applicant: DIONEX CORPORATIONInventors: Kannan SRINIVASAN, Sheetal BHARDWAJ, Rong LIN
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Publication number: 20150076005Abstract: An electrolytic device includes four channels separated by three charged barriers. The device can be used to suppress an eluent stream containing separated sample analyte ions and/or to pretreat a sample stream containing unseparated analyte ions.Type: ApplicationFiled: September 16, 2013Publication date: March 19, 2015Inventors: Kannan SRINIVASAN, Sheetal BHARDWAJ, Rong LIN