Patents by Inventor Sheikh Tamir Rashid

Sheikh Tamir Rashid has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vitro hepatic differentiation
    Patent number: 9284576
    Abstract: This invention relates to the induction of hepatic differentiation by culturing induced pluripotent stem (iPS) cells in an endoderm induction medium to produce a population of anterior definitive endoderm (ADE) cells and then culturing the population of ADE cells in a hepatic induction medium to produce a population of hepatic progenitor cells, which may be optionally differentiated into hepatocytes. The endoderm induction medium is a chemically defined medium which has fibroblast growth factor activity, stimulates SMAD2 and SMAD3 mediated signalling pathways and SMAD1, SMAD5 and SMAD9 mediated signalling pathways, and inhibits phosphatidylinositol 3-kinase (PI3K) and glycogen synthase kinase 3? (GSK3?); and the hepatic induction medium is a chemically defined medium which stimulates SMAD2 and SMAD3 mediated signalling pathways. These methods may be useful, for example, in producing hepatocytes and hepatic progenitor cells for cell-based therapies or disease modelling.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: March 15, 2016
    Assignee: Cambride Enterprise Limited
    Inventors: Ludovic Vallier, Sheikh Tamir Rashid, Nicholas Hannan, Hsin-Hua Cho
  • METHOD FOR GENOME MODIFICATION
    Publication number: 20130209426
    Abstract: The present disclosure includes methods for manipulation of the genome, to products obtained or obtainable from such methods, and uses of these products.
    Type: Application
    Filed: August 24, 2012
    Publication date: August 15, 2013
    Applicants: CAMBRIDGE ENTERPRISE LTD., GENOME RESEARCH LIMITED
    Inventors: Allan Bradley, Kosuke Yusa, Sheikh Tamir Rashid
  • VITRO HEPATIC DIFFERENTIATION
    Publication number: 20130156743
    Abstract: This invention relates to the induction of hepatic differentiation by culturing induced pluripotent stem (iPS) cells in an endoderm induction medium to produce a population of anterior definitive endoderm (ADE) cells and then culturing the population of ADE cells in a hepatic induction medium to produce a population of hepatic progenitor cells, which may be optionally differentiated into hepatocytes. The endoderm induction medium is a chemically defined medium which has fibroblast growth factor activity, stimulates SMAD2 and SMAD3 mediated signalling pathways and SMAD1, SMAD5 and SMAD9 mediated signalling pathways, and inhibits phosphatidylinositol 3-kinase (PI3K) and glycogen synthase kinase 3? (GSK3?); and the hepatic induction medium is a chemically defined medium which stimulates SMAD2 and SMAD3 mediated signalling pathways. These methods may be useful, for example, in producing hepatocytes and hepatic progenitor cells for cell-based therapies or disease modelling.
    Type: Application
    Filed: August 25, 2011
    Publication date: June 20, 2013
    Applicant: Cambridge Enterprise Limited
    Inventors: Ludovic Vallier, Sheikh Tamir Rashid, Nicholas Hannan, Hsin-Hua Cho