Patents by Inventor Sheila A. Grant
Sheila A. Grant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11796473Abstract: The invention broadly relates techniques for imaging and medical diagnosis and, more particularly, to the fabrication of flexible plasmonic gratings and the use thereof in detection of biomarkers. A first aspect of the invention provides for techniques for the fabrication of novel, flexible plasmonic gratings that can be inexpensively fabricated onto fiber optic cables, flexible films and substrates with non-uniform surfaces to enhance the imaging resolution. A second aspect of the invention provides for an ultra¬high sensitivity (single molecule counting) biomarker detection platform useable for medical diagnosis based on a fluorescent sandwich ELISA assay performed on a plasmonic grating platform incorporated with a fluorescence detection unit.Type: GrantFiled: July 11, 2018Date of Patent: October 24, 2023Assignee: The Curators of the University of MissouriInventors: Shubhra Gangopadhyay, Sangho Bok, Cherian Joseph Mathai, Keshab Gangopadhyay, Sheila Grant, Aaron Wood, Syed Barizuddin
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Publication number: 20220175534Abstract: The present disclosure provides collagen bioink compositions and chemically uncrosslinked and crosslinked collagen structures including collagen microparticles and scaffolds. Also provided are methods of their fabrication and use. Applications for using these collagen structures include treatments of damaged tissue, particularly those caused by osteoarthritis.Type: ApplicationFiled: December 7, 2021Publication date: June 9, 2022Inventors: Sheila Grant, Colten Snider, David Grant
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Publication number: 20220168463Abstract: The present disclosure describes a treatment composition comprising a nanoparticle composition comprising nanoparticles functionalized with surface amine groups and a crosslinking composition comprising genipin. The disclosure also describes a kit comprising the treatment composition, and instructions for using the kit to crosslink the nanoparticles to a tissue graft. The treatment composition and kit can be used to crosslink nanoparticles to a tissue graft, and the resulting tissue graft can be used to replace defective tissue in a subject in need thereof.Type: ApplicationFiled: November 30, 2021Publication date: June 2, 2022Inventors: Sheila Grant, David Grant, Colten Snider, Mitchell Bellrichard, Daniel Grant
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Publication number: 20200173922Abstract: The invention broadly relates techniques for imaging and medical diagnosis and, more particularly, to the fabrication of flexible plasmonic gratings and the use thereof in detection of biomarkers. A first aspect of the invention provides for techniques for the fabrication of novel, flexible plasmonic gratings that can be inexpensively fabricated onto fiber optic cables, flexible films and substrates with non-uniform surfaces to enhance the imaging resolution. A second aspect of the invention provides for an ultra¬high sensitivity (single molecule counting) biomarker detection platform useable for medical diagnosis based on a fluorescent sandwich ELISA assay performed on a plasmonic grating platform incorporated with a fluorescence detection unit.Type: ApplicationFiled: July 11, 2018Publication date: June 4, 2020Inventors: Shubhra GANGOPADHYAY, Sangho BOK, Cherian Joseph MATHAI, Keshab GANGOPADHYAY, Sheila GRANT, Aaron WOOD, Syed BARIZUDDIN
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Patent number: 10490679Abstract: Provided are nanograting structures and methods of fabrication thereof that allow for stable, robust gratings and nanostructure embedded gratings that enhance electromagnetic field, fluorescence, and photothermal coupling through surface plasmon or, photonic resonance. The gratings produced exhibit long term stability of the grating structure and improved shelf life without degradation of the properties such as fluorescence enhancement. Embodiments of the invention build nanograting structures layer-by-layer to optimize structural and optical properties and to enhance durability.Type: GrantFiled: October 12, 2018Date of Patent: November 26, 2019Assignee: The Curators of the University of MissouriInventors: Shubhra Gangopadhyay, Sangho Bok, Samiullah Pathan, Cherian Joseph Mathai, Sagnik Basuray, Keshab Gangopadhyay, Biyan Chen, Sheila Grant, Aaron Wood
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Publication number: 20190051863Abstract: Provided are nanograting structures and methods of fabrication thereof that allow for stable, robust gratings and nanostructure embedded gratings that enhance electromagnetic field, fluorescence, and photothermal coupling through surface plasmon or, photonic resonance. The gratings produced exhibit long term stability of the grating structure and improved shelf life without degradation of the properties such as fluorescence enhancement. Embodiments of the invention build nanograting structures layer-by-layer to optimize structural and optical properties and to enhance durability.Type: ApplicationFiled: October 12, 2018Publication date: February 14, 2019Inventors: Shubhra GANGOPADHYAY, Sangho BOK, Samiullah PATHAN, Cherian Joseph MATHAI, Sagnik BASURAY, Keshab GANGOPADHYAY, Biyan CHEN, Sheila GRANT, Aaron WOOD
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Patent number: 10103357Abstract: Provided are nanograting structures and methods of fabrication thereof that allow for stable, robust gratings and nanostructure embedded gratings that enhance electromagnetic field, fluorescence, and photothermal coupling through surface plasmon or, photonic resonance. The gratings produced exhibit long term stability of the grating structure and improved shelf life without degradation of the properties such as fluorescence enhancement. Embodiments of the invention build nanograting structures layer-by-layer to optimize structural and optical properties and to enhance durability.Type: GrantFiled: February 7, 2017Date of Patent: October 16, 2018Assignee: The Curators of the University of MissouriInventors: Shubhra Gangopadhyay, Sangho Bok, Samiullah Pathan, Cherian Joseph Mathai, Sagnik Basuray, Keshab Gangopadhyay, Biyan Chen, Sheila Grant, Aaron Wood
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Patent number: 9827323Abstract: Disclosed are compositions comprising collagen covalently bound to particles, wherein covalent bonds are formed between reactive groups of the collagen and reactive groups of the particles, and wherein the particles have an average particle diameter ranging from 20 to 1000 nanometers. Also disclosed are various methods that utilize the compositions.Type: GrantFiled: June 7, 2011Date of Patent: November 28, 2017Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURIInventors: Anthony Harris, Johnathan Thompson, Rebecca Rone, Sheila Grant, David Grant
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Patent number: 9181571Abstract: A DNA amplification device utilizing a polydimethylsiloxane (PDMS) and silicon substrate coated with spin-on glass (SOG) is provided. This PDMS layer is irreversibly bonded to the SOG layer of the silicon substrate using oxygen plasma. The amplification device is an inexpensive, microfluidic device, which can be utilized as a portable thermo-cycler to perform PCR amplification of DNA in the field.Type: GrantFiled: September 17, 2014Date of Patent: November 10, 2015Assignee: The Curators of the University of MissouriInventors: Venumadhav Korampally, Shubhra Gangopadhyay, Keshab Gangopadhyay, Sheila A. Grant, Steven B. Kleiboeker, Shantanu Bhattacharya, Yuanfang Gao
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Publication number: 20150004648Abstract: A DNA amplification device utilizing a polydimethylsiloxane (PDMS) and silicon substrate coated with spin-on glass (SOG) is provided. This PDMS layer is irreversibly bonded to the SOG layer of the silicon substrate using oxygen plasma. The amplification device is an inexpensive, microfluidic device, which can be utilized as a portable thermo-cycler to perform PCR amplification of DNA in the field.Type: ApplicationFiled: September 17, 2014Publication date: January 1, 2015Inventors: VENUMADHAV KORAMPALLY, SHUBHRA GANGOPADHYAY, KESHAB GANGOPADHYAY, SHEILA A. GRANT, STEVEN B. KLEIBOEKER, SHANTANU BHATTACHARYA, YUANFANG GAO
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Publication number: 20140302104Abstract: Disclosed are compositions comprising collagen covalently bound to particles, wherein covalent bonds are formed between reactive groups of the collagen and reactive groups of the particles, and wherein the particles have an average particle diameter ranging from 20 to 1000 nanometers. Also disclosed are various methods that utilize the compositions.Type: ApplicationFiled: April 17, 2014Publication date: October 9, 2014Applicant: The Curators of the University of MissouriInventors: Anthony HARRIS, Jonathan THOMPSON, Rebecca RONE, Sheila GRANT, David GRANT
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Publication number: 20140099675Abstract: A DNA amplification device utilizing a polydimethylsiloxane (PDMS) and silicon substrate coated with spin-on glass (SOG) is provided. This PDMS layer is irreversibly bonded to the SOG layer of the silicon substrate using oxygen plasma. The amplification device is an inexpensive, microfluidic device, which can be utilized as a portable thermo-cycler to perform PCR amplification of DNA in the field.Type: ApplicationFiled: September 9, 2013Publication date: April 10, 2014Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURIInventors: VENUMADHAV KORAMPALLY, SHUBHRA GANGOPADHYAY, KESHAB GANGOPADHYAY, SHEILA A. GRANT, STEVEN B. KLEIBOEKER, SHANTANU BHATTACHARYA, YUANFANG GAO
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Patent number: 8545769Abstract: A DNA amplification device utilizing a polydimethylsiloxane (PDMS) and silicon substrate coated with spin-on glass (SOG) is provided. This PDMS layer is irreversibly bonded to the SOG layer of the silicon substrate using oxygen plasma. The amplification device is an inexpensive, microfluidic device, which can be utilized as a portable thermo-cycler to perform PCR amplification of DNA in the field.Type: GrantFiled: March 9, 2012Date of Patent: October 1, 2013Assignee: The Curators of the University of MissouriInventors: Venumadhav Korampally, Shubhra Gangopadhyay, Keshab Gangopadhyay, Sheila A. Grant, Steven B. Kleiboeker, Shantanu Bhattacharya, Yuanfang Gao
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Publication number: 20120178130Abstract: A DNA amplification device utilizing a polydimethylsiloxane (PDMS) and silicon substrate coated with spin-on glass (SOG) is provided. This PDMS layer is irreversibly bonded to the SOG layer of the silicon substrate using oxygen plasma. The amplification device is an inexpensive, microfluidic device, which can be utilized as a portable thermo-cycler to perform PCR amplification of DNA in the field.Type: ApplicationFiled: March 9, 2012Publication date: July 12, 2012Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURIInventors: VENUMADHAV KORAMPALLY, SHUBHRA GANGOPADHYAY, KESHAB GANGOPADHYAY, SHEILA A. GRANT, STEVEN B. KLEIBOEKER, SHANTANU BHATTACHARYA, YUANFANG GAO
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Patent number: 8173077Abstract: A DNA amplification device utilizing a polydimethylsiloxane (PDMS) and silicon substrate coated with spin-on glass (SOG) is provided. This PDMS layer is irreversibly bonded to the SOG layer of the silicon substrate using oxygen plasma. The amplification device is an inexpensive, microfluidic device, which can be utilized as a portable thermo-cycler to perform PCR amplification of DNA in the field.Type: GrantFiled: December 15, 2006Date of Patent: May 8, 2012Assignee: The Curators of the University of MissouriInventors: Venumadhav Korampally, Shubhra Gangopadhyay, Keshab Gangopadhyay, Sheila A. Grant, Steven B. Kleiboeker, Shantanu Bhattacharya, Yuanfang Gao
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Publication number: 20120070466Abstract: Disclosed are compositions comprising collagen covalently bound to particles, wherein covalent bonds are formed between reactive groups of the collagen and reactive groups of the particles, and wherein the particles have an average particle diameter ranging from 20 to 1000 nanometers. Also disclosed are various methods that utilize the compositions.Type: ApplicationFiled: June 7, 2011Publication date: March 22, 2012Applicant: UNIVERSITY OF MISSOURI, OFFICE OF IPAInventors: Anthony Harris, Jonathan Thompson, Rebecca Rone, Sheila Grant, David Grant
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Patent number: 7943390Abstract: A device and a method for measuring viscosity that includes attaching molecular rotors to a solid surface, exposing the solid surface to a fluid having a viscosity to be measured, and taking optical measurements to determine viscosity. The solid surface is preferably quartz, polystyrene or silicate glass, such as a fiber optic probe or a glass cuvette. The molecular rotors are of the type that includes an electron-donor group and electron-acceptor group that are linked by a single bond so that the groups may rotate with respect to one another, and that exhibit a fluorescence emission when rotation is hindered.Type: GrantFiled: April 20, 2009Date of Patent: May 17, 2011Assignees: The Curators of the University of Missouri, The Regents of the University of California, La Jolla Bioengineering InstituteInventors: Mark A. Haidekker, Sheila Grant, Emmanuel Theodorakis, Marcos Intaglietta, John A. Frangos
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Patent number: 7670844Abstract: A device and a method for measuring viscosity that includes attaching molecular rotors to a solid surface, exposing the solid surface to a fluid having a viscosity to be measured, and taking optical measurements to determine viscosity. The solid surface is preferably quartz, polystyrene or silicate glass, such as a fiber optic probe or a glass cuvette. The molecular rotors are of the type that includes an electron-donor group and electron-acceptor group that are linked by a single bond so that the groups may rotate with respect to one another, and that exhibit a fluorescence emission when rotation is hindered.Type: GrantFiled: January 20, 2005Date of Patent: March 2, 2010Assignees: The Curators of the University of Missouri, The Regents of the University of California, La Jolla Bioengineering InstituteInventors: Mark A. Haidekker, Sheila Grant, Emmanuel Theodorakis, Marcos Intaglietta, John A. Frangos
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Publication number: 20090227880Abstract: A device and a method for measuring viscosity that includes attaching molecular rotors to a solid surface, exposing the solid surface to a fluid having a viscosity to be measured, and taking optical measurements to determine viscosity. The solid surface is preferably quartz, polystyrene or silicate glass, such as a fiber optic probe or a glass cuvette. The molecular rotors are of the type that includes an electron-donor group and electron-acceptor group that are linked by a single bond so that the groups may rotate with respect to one another, and that exhibit a fluorescence emission when rotation is hindered.Type: ApplicationFiled: April 20, 2009Publication date: September 10, 2009Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURIInventors: Mark A. Haidekker, Sheila Grant, Emmanuel Theodorakis, Marcos Intaglietta, John A. Frangos
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Publication number: 20090148910Abstract: A DNA amplification device utilizing a polydimethylsiloxane (PDMS) and silicon substrate coated with spin-on glass (SOG) is provided. This PDMS layer is irreversibly bonded to the SOG layer of the silicon substrate using oxygen plasma. The amplification device is an inexpensive, microfluidic device, which can be utilized as a portable thermo-cycler to perform PCR amplification of DNA in the field.Type: ApplicationFiled: December 15, 2006Publication date: June 11, 2009Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURIInventors: Venumadhav Korampally, Shubhra Gangopadhyay, Keshab Gangopadhyay, Sheila A. Grant, Steven B. Kleiboeker, Shantanu Bhattacharya, Yuanfang Gao