Patents by Inventor Sheila A. Lloyd
Sheila A. Lloyd has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7742877Abstract: Methods, apparatus and computer program products are provided for identifying a component of culture medium based on the parameters (e.g., physical, chemical, biological and/or topological characteristics) of compounds from within a compound library. In preferred embodiments, the compound library is a peptide library. Also provided are methods of selecting a compound library from a larger compound space based on whole molecule (i.e., global) parameters of the compounds. Preferably, this method is practiced in conjunction with a method of identifying a component of a culture medium. Further provided are methods of predicting a biological activity of a peptide based on at least one whole molecule parameter of the peptide. This method finds use in methods of drug discovery, identifying components of culture medium, and identifying and/or designing peptides with particular pharmacological or therapeutic activities.Type: GrantFiled: July 22, 1999Date of Patent: June 22, 2010Assignee: Becton, Dickinson & CompanyInventors: Robert L. Campbell, Perry D. Haaland, Douglas B. Sherman, Walter William Stewart, II, Sheila A. Lloyd
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Publication number: 20090124008Abstract: The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cellular proteins. Many of the peptides of the invention may be produced in large quantity by recombinant techniques and formulated in culture medium to produce the desired effect on cultured cells and tissues. Certain of the libraries of the invention and the peptides identified in them are particularly useful in concatemer-based recombinant expression methods.Type: ApplicationFiled: August 8, 2007Publication date: May 14, 2009Applicant: Becton, Dickinson and CompanyInventors: Perry D. Haaland, Douglas B. Sherman, Robert L. Campbell, Walter William Stewart, Sheila A. Lloyd, Bruce Wayne Erickson, Ann Hart Erickson
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Patent number: 7267983Abstract: The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cellular proteins. Many of the peptides of the invention may be produced in large quantity by recombinant techniques and formulated in culture medium to produce the desired effect on cultured cells and tissues. Certain of the libraries of the invention and the peptides identified in them are particularly useful in concatemer-based recombinant expression methods.Type: GrantFiled: May 7, 2004Date of Patent: September 11, 2007Assignee: Becton, Dickinson and CompanyInventors: Perry D. Haaland, Douglas B. Sherman, Robert L. Campbell, Walter William Stewart, Sheila A. Lloyd, Ann Hart Erickson, legal representative, Bruce Wayne Erickson, deceased
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Publication number: 20070190584Abstract: Rare cells are separated from a sample fluid by a positive selection or negative selection antibody by centrifuging in a tube containing a harvesting float. The harvesting float has an axial passage and a density to settle in the sample fluid and expand the layer of the target component. The positive selection antibody is preferably coupled to a particulate carrier, such as a microbead, to attach to the target component. The negative selection antibody forms a complex or conjugate with a contaminating component. In the positive separation, the particulate carrier is recovered in the axial passage of the float.Type: ApplicationFiled: March 12, 2007Publication date: August 16, 2007Applicant: BECTON, DICKINSON AND COMPANYInventors: Stewart Jurgensen, Sheila Lloyd
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Patent number: 7179635Abstract: The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cellular proteins. Many of the peptides of the invention may be produced in large quantity by recombinant techniques and formulated in culture medium to produce the desired effect on cultured cells and tissues. Certain of the libraries of the invention and the peptides identified in them are particularly useful in concatemer-based recombinant expression methods.Type: GrantFiled: May 7, 2004Date of Patent: February 20, 2007Assignee: Becton, Dickinson and CompanyInventors: Perry D. Haaland, Douglas B. Sherman, Robert L. Campbell, Walter William Stewart, Sheila A. Lloyd, Ann Hart Erickson, legal representative, Bruce Wayne Erickson, deceased
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Publication number: 20060088889Abstract: The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cellular proteins. Many of the peptides of the invention may be produced in large quantity by recombinant techniques and formulated in culture medium to produce the desired effect on cultured cells and tissues. Certain of the libraries of the invention and the peptides identified in them are particularly useful in concatemer-based recombinant expression methods.Type: ApplicationFiled: December 9, 2005Publication date: April 27, 2006Applicant: Becton, Dickinson and CompanyInventors: Perry Haaland, Douglas Sherman, Robert Campbell, Walter Stewart, Sheila Lloyd, Bruce Erickson, Ann Erickson
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Publication number: 20050186634Abstract: The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cellular proteins. Many of the peptides of the invention may be produced in large quantity by recombinant techniques and formulated in culture medium to produce the desired effect on cultured cells and tissues. Certain of the libraries of the invention and the peptides identified in them are particularly useful in concatemer-based recombinant expression methods.Type: ApplicationFiled: May 7, 2004Publication date: August 25, 2005Inventors: Perry Haaland, Douglas Sherman, Robert Campbell, Walter Stewart, Sheila Lloyd, Bruce Erickson, Ann Erickson
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Publication number: 20040265910Abstract: The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cellular proteins. Many of the peptides of the invention may be produced in large quantity by recombinant techniques and formulated in culture medium to produce the desired effect on cultured cells and tissues. Certain of the libraries of the invention and the peptides identified in them are particularly useful in concatemer-based recombinant expression methods.Type: ApplicationFiled: May 7, 2004Publication date: December 30, 2004Inventors: Perry D. Haaland, Douglas B. Sherman, Robert L. Campbell, Walter William Stewart, Sheila A. Lloyd, Bruce Wayne Erickson, Ann Hart Erickson
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Publication number: 20040265911Abstract: The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cellular proteins. Many of the peptides of the invention may be produced in large quantity by recombinant techniques and formulated in culture medium to produce the desired effect on cultured cells and tissues. Certain of the libraries of the invention and the peptides identified in them are particularly useful in concatemer-based recombinant expression methods.Type: ApplicationFiled: May 7, 2004Publication date: December 30, 2004Inventors: Perry D. Haaland, Douglas B. Sherman, Robert L. Campbell, Walter William Stewart, Sheila A. Lloyd, Bruce Wayne Erickson, Ann Hart Erickson
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Patent number: 6759510Abstract: The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cellular proteins. Many of the peptides of the invention may be produced in large quantity by recombinant techniques and formulated in culture medium to produce the desired effect on cultured cells and tissues. Certain of the libraries of the invention and the peptides identified in them are particularly useful in concatemer-based recombinant expression methods.Type: GrantFiled: June 30, 2000Date of Patent: July 6, 2004Assignee: Becton, Dickinson and CompanyInventors: Perry D. Haaland, Douglas B. Sherman, Robert L. Campbell, Walter William Stewart, Sheila A. Lloyd, Bruce Wayne Erickson
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Publication number: 20030165808Abstract: Methods, apparatus and computer program products are provided for identifying a component of culture medium based on the parameters (e.g, physical, chemical, biological and/or topological characteristics) of compounds from within a compound library. In preferred embodiments, the compound library is a peptide library. Also provided are methods of selecting a compound library from a larger compound space based on whole molecule (i.e., global) parameters of the compounds. Preferably, this method is practiced in conjunction with a method of identifying a component of a culture medium. Further provided are methods of predicting a biological activity of a peptide based on at least one whole molecule parameter of the peptide. This method finds use in methods of drug discovery, identifying components of culture medium, and identifying and/or designing peptides with particular pharmacological or therapeutic activities.Type: ApplicationFiled: March 5, 2002Publication date: September 4, 2003Inventors: Robert L. Campbell, Perry D. Haaland, Douglas B. Sherman, Walter William Stewart, Sheila A. Lloyd
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Publication number: 20030022152Abstract: Methods, apparatus and computer program products are provided for identifying a component of culture medium based on the parameters (e g, physical, chemical, biological and/or topological characteristics) of compounds from within a compound library. In preferred embodiments, the compound library is a peptide library. Also provided are methods of selecting a compound library from a larger compound space based on whole molecule (i.e., global) parameters of the compounds. Preferably, this method is practiced in conjunction with a method of identifying a component of a culture medium. Further provided are methods of predicting a biological activity of a peptide based on at least one whole molecule parameter of the peptide. This method finds use in methods of drug discovery, identifying components of culture medium, and identifying and/or designing peptides with particular pharmacological or therapeutic activities.Type: ApplicationFiled: March 5, 2002Publication date: January 30, 2003Inventors: Robert L. Campbell, Perry D. Haaland, Douglas B. Sherman, Walter William Stewart, Sheila A. Lloyd