Patents by Inventor Sheila Downs

Sheila Downs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions for importing biologically active molecules into cells
    Patent number: 8324148
    Abstract: The present invention relates to the delivery of biologically active molecules, such as peptides, nucleic acids and therapeutic agents, into the interior of cells by administering to the cells a complex comprising the molecule linked to an importation competent signal peptide. Such delivery can be utilized for purposes such as peptide therapy, gene transfer, and antisense therapy to regulate and/or eradicate systemic inflammatory response syndromes such as endotoxic shock.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: December 4, 2012
    Assignee: Vanderbilt University
    Inventors: Jack J. Hawiger, Daniel Robinson, Ruth Ann Veach, Xue Yan Liu, Danya Liu, Sheila Downs, Robert D. Collins, Yao-Zhong Lin
  • Cell permeable peptides for inhibition of inflammatory reactions and methods of use
    Patent number: 7553929
    Abstract: The present invention relates to the delivery of biologically active molecules, such as peptides, into the interior of cells by administering to the cells a complex comprising the molecule linked to an importation competent signal peptide. Such delivery can be utilized, for example, to treat and/or prevent inflammatory conditions, e.g., but not limited to, systemic inflammatory reactions such as endotoxic shock, localized inflammatory reactions such as inflammatory skin diseases and conditions, and inflammatory diseases such as autoimmune diseases.
    Type: Grant
    Filed: November 29, 2000
    Date of Patent: June 30, 2009
    Assignee: Vanderbilt University
    Inventors: Jack J. Hawiger, Daniel Robinson, Ruth Ann Veach, Xue Yan Liu, Danya Liu, Sheila Downs, Robert D. Collins, Yao-Zhong Lin
  • Cell permeable peptides for inhibition of inflammatory reactions and methods of use
    Publication number: 20040235746
    Abstract: The present invention relates to the delivery of biologically active molecules, such as peptides, into the interior of cells by administering to the cells a complex comprising the molecule linked to an importation competent signal peptide. Such delivery can be utilized, for example, to treat and/or prevent inflammatory conditions, e.g., but not limited to, systemic inflammatory reactions such as endotoxic shock, localized inflammatory reactions such as inflammatory skin diseases and conditions, and inflammatory diseases such as autoimmune diseases.
    Type: Application
    Filed: February 20, 2003
    Publication date: November 25, 2004
    Inventors: Jack J. Hawiger, Daniel Robinson, Ruth Ann Veach, Xue Yan Liu, Danya Liu, Sheila Downs, Robert D. Collins, Yao-Zhong Lin
  • Compositions and methods for importing biologically active molecules into cells and for treating inflammation
    Publication number: 20040147435
    Abstract: The present invention relates to the delivery of biologically active molecules, such as peptides, nucleic acids and therapeutic agents, into the interior of cells by administering to the cells a complex comprising the molecule linked to an importation competent signal peptide. Such delivery can be utilized for purposes such as peptide therapy, gene transfer, and antisense therapy to regulate and/or eradicate systemic inflammatory response syndromes such as endotoxic shock.
    Type: Application
    Filed: December 13, 2002
    Publication date: July 29, 2004
    Applicant: Vanderbilt University
    Inventors: Jack J. Hawiger, Daniel Robinson, Ruth Ann Veach, Xue Yan Liu, Danya Liu, Sheila Downs, Robert D. Collins, Yao-Zhong Lin