Patents by Inventor Sheila LOPEZ-COBO

Sheila LOPEZ-COBO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODULATION OF SUV39H1 EXPRESSION BY RNAS
    Publication number: 20250115916
    Abstract: The invention provides compositions and methods for modulating expression of SUV39H1 using inhibitory or activating polynucleotides based on the sequence of a long noncoding RNA or of a short hairpin RNA (shRNA).
    Type: Application
    Filed: January 23, 2023
    Publication date: April 10, 2025
    Inventors: Sebastian AMIGORENA, Michael SAITAKIS, Sheila LOPEZ-COBO, Jaime Rodrigo FUENTEALBA
  • IMMUNE CELLS DEFECTIVE FOR SUV39H1
    Publication number: 20220251572
    Abstract: The present invention relates to an improved immune cell expressing an antigen-specific receptor such as a CAR or TCR, in which SUV39H1 is inactivated, optionally combined with disruption of the TRAC locus and/or deletion of one or more ITAMs. The invention also provides compositions comprising such cells, methods of producing such cells, and uses of such cells in adoptive cell therapy, e.g. in cancer or inflammatory diseases.
    Type: Application
    Filed: July 23, 2020
    Publication date: August 11, 2022
    Inventors: Sebastian AMIGORENA, Michael SAITAKIS, Sheila LOPEZ-COBO, Jaime Rodrigo FUENTEALBA