Patents by Inventor Sheila NIRENBERG
Sheila NIRENBERG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11640681Abstract: A method is disclosed including: receiving raw image data corresponding to a series of raw images; processing the raw image data with an encoder to generate encoded data, where the encoder is characterized by an input/output transformation that substantially mimics the input/output transformation of one or more retinal cells of a vertebrate retina; and applying a first machine vision algorithm to data generated based at least in part on the encoded data.Type: GrantFiled: September 3, 2020Date of Patent: May 2, 2023Assignee: CORNELL UNIVERSITYInventors: Sheila Nirenberg, Iliya Bomash
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Patent number: 11430263Abstract: A method is described that includes receiving raw image data corresponding to a series of raw images, and processing the raw image data with an encoder of a processing device to generate encoded data. The encoder is characterized by an input/output transformation that substantially mimics the input/output transformation of at least one retinal cell of a vertebrate retina. The method also includes processing the encoded data to generate dimension reduced encoded data by applying a dimension reduction algorithm to the encoded data. The dimension reduction algorithm is configured to compress an amount of information contained in the encoded data. An apparatus and system usable with such a method is also described.Type: GrantFiled: December 20, 2019Date of Patent: August 30, 2022Assignee: CORNELL UNIVERSITYInventor: Sheila Nirenberg
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Publication number: 20200401837Abstract: A method is disclosed including: receiving raw image data corresponding to a series of raw images; processing the raw image data with an encoder to generate encoded data, where the encoder is characterized by an input/output transformation that substantially mimics the input/output transformation of one or more retinal cells of a vertebrate retina; and applying a first machine vision algorithm to data generated based at least in part on the encoded data.Type: ApplicationFiled: September 3, 2020Publication date: December 24, 2020Applicant: CORNELL UNIVERSITYInventors: Sheila NIRENBERG, Illya Bomash
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Publication number: 20200143138Abstract: A method is described that includes receiving raw image data corresponding to a series of raw images, and processing the raw image data with an encoder of a processing device to generate encoded data. The encoder is characterized by an input/output transformation that substantially mimics the input/output transformation of at least one retinal cell of a vertebrate retina. The method also includes processing the encoded data to generate dimension reduced encoded data by applying a dimension reduction algorithm to the encoded data. The dimension reduction algorithm is configured to compress an amount of information contained in the encoded data. An apparatus and system usable with such a method is also described.Type: ApplicationFiled: December 20, 2019Publication date: May 7, 2020Applicant: Cornell UniversityInventor: Sheila NIRENBERG
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Publication number: 20200061387Abstract: A method of treating a subject afflicted with a retinal degenerative or neurodegenerative disease including administering an optogenetic therapeutic to the subject, where the optogenetic therapeutic includes an optogenetic protein fused or linked to a marker protein. An optogenetic therapeutic for use in treating a subject afflicted with a retinal degenerative or neurodegenerative disease, including an optogenetic protein fused or linked to a marker protein.Type: ApplicationFiled: November 4, 2019Publication date: February 27, 2020Inventor: Sheila Nirenberg
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Patent number: 10561841Abstract: The invention provides a retinal prosthetic method and device that mimics the responses of the retina to a broad range of stimuli, including natural stimuli. Ganglion cell firing patterns are generated in response to a stimulus using a set of encoders, interfaces, and transducers, where each transducer targets a single cell or a small number of cells. The conversion occurs on the same time scale as that carried out by the normal retina. In addition, aspects of the invention may be used with robotic or other mechanical devices, where processing of visual information is required. The encoders may be adjusted over time with aging or the progression of a disease.Type: GrantFiled: August 6, 2018Date of Patent: February 18, 2020Assignee: CORNELL UNIVERSITYInventor: Sheila Nirenberg
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Patent number: 10515269Abstract: A method is described that includes receiving raw image data corresponding to a series of raw images, and processing the raw image data with an encoder of a processing device to generate encoded data. The encoder is characterized by an input/output transformation that substantially mimics the input/output transformation of at least one retinal cell of a vertebrate retina. The method also includes processing the encoded data to generate dimension reduced encoded data by applying a dimension reduction algorithm to the encoded data. The dimension reduction algorithm is configured to compress an amount of information contained in the encoded data. An apparatus and system usable with such a method is also described.Type: GrantFiled: April 20, 2016Date of Patent: December 24, 2019Assignee: CORNELL UNIVERSITYInventor: Sheila Nirenberg
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Publication number: 20190279021Abstract: A method is disclosed including: receiving raw image data corresponding to a series of raw images; processing the raw image data with an encoder to generate encoded data, where the encoder is characterized by an input/output transformation that substantially mimics the input/output transformation of one or more retinal cells of a vertebrate retina; and applying a first machine vision algorithm to data generated based at least in part on the encoded data.Type: ApplicationFiled: May 23, 2019Publication date: September 12, 2019Inventors: Sheila NIRENBERG, Illya Bomash
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Publication number: 20190201693Abstract: The invention provides a retinal prosthetic method and device that mimics the responses of the retina to a broad range of stimuli, including natural stimuli. Ganglion cell firing patterns are generated in response to a stimulus using a set of encoders, interfaces, and transducers, where each transducer targets a single cell or a small number of cells. The conversion occurs on the same time scale as that carried out by the normal retina. In addition, aspects of the invention may be used with robotic or other mechanical devices, where processing of visual information is required. The encoders may be adjusted over time with aging or the progression of a disease.Type: ApplicationFiled: August 6, 2018Publication date: July 4, 2019Inventor: Sheila NIRENBERG
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Patent number: 10303970Abstract: A method is disclosed including: receiving raw image data corresponding to a series of raw images; processing the raw image data with an encoder to generate encoded data, where the encoder is characterized by an input/output transformation that substantially mimics the input/output transformation of one or more retinal cells of a vertebrate retina; and applying a first machine vision algorithm to data generated based at least in part on the encoded data.Type: GrantFiled: January 17, 2017Date of Patent: May 28, 2019Assignee: CORNELL UNIVERSITYInventors: Sheila Nirenberg, Illya Bomash
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Patent number: 10039921Abstract: The invention provides a retinal prosthetic method and device that mimics the responses of the retina to a broad range of stimuli, including natural stimuli. Ganglion cell firing patterns are generated in response to a stimulus using a set of encoders, interfaces, and transducers, where each transducer targets a single cell or a small number of cells. The conversion occurs on the same time scale as that carried out by the normal retina. In addition, aspects of the invention may be used with robotic or other mechanical devices, where processing of visual information is required. The encoders may be adjusted over time with aging or the progression of a disease.Type: GrantFiled: December 28, 2015Date of Patent: August 7, 2018Assignee: CORNELL UNIVERSITYInventor: Sheila Nirenberg
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Publication number: 20180104507Abstract: A method of treating a subject afflicted with a retinal degenerative or neurodegenerative disease including administering an optogenetic therapeutic to the subject, where the optogenetic therapeutic includes an optogenetic protein fused or linked to a marker protein. An optogenetic therapeutic for use in treating a subject afflicted with a retinal degenerative or neurodegenerative disease, including an optogenetic protein fused or linked to a marker protein.Type: ApplicationFiled: October 18, 2017Publication date: April 19, 2018Inventor: Sheila Nirenberg
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Publication number: 20180089493Abstract: A method is described that includes receiving raw image data corresponding to a series of raw images, and processing the raw image data with an encoder of a processing device to generate encoded data. The encoder is characterized by an input/output transformation that substantially mimics the input/output transformation of at least one retinal cell of a vertebrate retina. The method also includes processing the encoded data to generate dimension reduced encoded data by applying a dimension reduction algorithm to the encoded data. The dimension reduction algorithm is configured to compress an amount of information contained in the encoded data. An apparatus and system usable with such a method is also described.Type: ApplicationFiled: April 20, 2016Publication date: March 29, 2018Inventor: Sheila NIRENBERG
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Patent number: 9925373Abstract: A method improving or restoring neural function in a mammalian subject in need thereof, the method including: using an input receiver to record an input signal generated by a first set of nerve cells; using an encoder unit including a set of encoders to generate a set of coded outputs in response to the input signal; using the encoded outputs to drive an output generator; and using an output generator to activate a second set of nerve cells wherein the second set of nerve cells is separated from the first set of nerve cells by impaired set of signaling cells. In some embodiments, the second set of nerve cells produces a response that is substantially the same as the response in an unimpaired subject.Type: GrantFiled: March 17, 2016Date of Patent: March 27, 2018Assignee: CORNELL UNIVERSITYInventor: Sheila Nirenberg
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Publication number: 20170255837Abstract: A method is disclosed including: receiving raw image data corresponding to a series of raw images; processing the raw image data with an encoder to generate encoded data, where the encoder is characterized by an input/output transformation that substantially mimics the input/output transformation of one or more retinal cells of a vertebrate retina; and applying a first machine vision algorithm to data generated based at least in part on the encoded data.Type: ApplicationFiled: January 17, 2017Publication date: September 7, 2017Inventors: Sheila NIRENBERG, Illya BOMASH
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Patent number: 9547804Abstract: A method is disclosed including: receiving raw image data corresponding to a series of raw images; processing the raw image data with an encoder to generate encoded data, where the encoder is characterized by an input/output transformation that substantially mimics the input/output transformation of one or more retinal cells of a vertebrate retina; and applying a first machine vision algorithm to data generated based at least in part on the encoded data.Type: GrantFiled: August 24, 2012Date of Patent: January 17, 2017Assignee: Cornell UniversityInventors: Sheila Nirenberg, Illya Bomash
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Publication number: 20160263379Abstract: The invention provides a retinal prosthetic method and device that mimics the responses of the retina to a broad range of stimuli, including natural stimuli. Ganglion cell firing patterns are generated in response to a stimulus using a set of encoders, interfaces, and transducers, where each transducer targets a single cell or a small number of cells. The conversion occurs on the same time scale as that carried out by the normal retina. In addition, aspects of the invention may be used with robotic or other mechanical devices, where processing of visual information is required. The encoders may be adjusted over time with aging or the progression of a disease.Type: ApplicationFiled: December 28, 2015Publication date: September 15, 2016Inventor: Sheila NIRENBERG
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Publication number: 20160193464Abstract: A method improving or restoring neural function in a mammalian subject in need thereof is disclosed, the method including: using an input receiver to record an input signal generated by a first set of nerve cells; using an a encoder unit including a set of encoders to generate a set of coded outputs in response to the input signal; using the encoded outputs to drive an output generator; and using an output generator to activate a second set of nerve cells wherein the second set of nerve cells is separated from the first set of nerve cells by impaired set of signaling cells. In some embodiments, the second set of nerve cells produces a response that is substantially the same as the response in an unimpaired subject.Type: ApplicationFiled: March 17, 2016Publication date: July 7, 2016Applicant: Cornell UniversityInventor: Sheila NIRENBERG
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Patent number: 9302103Abstract: A method improving or restoring neural function in a mammalian subject in need thereof, the method including: using an input receiver to record an input signal generated by a first set of nerve cells; using an a encoder unit including a set of encoders to generate a set of coded outputs in response to the input signal; using the encoded outputs to drive an output generator; and using an output generator to activate a second set of nerve cells wherein the second set of nerve cells is separated from the first set of nerve cells by impaired set of signaling cells. In some embodiments, the second set of nerve cells produces a response that is substantially the same as the response in an unimpaired subject.Type: GrantFiled: September 12, 2011Date of Patent: April 5, 2016Assignee: Cornell UniversityInventor: Sheila Nirenberg
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Patent number: 9220634Abstract: The invention provides a retinal prosthetic method and device that mimics the responses of the retina to a broad range of stimuli, including natural stimuli. Ganglion cell firing patterns are generated in response to a stimulus using a set of encoders, interfaces, and transducers, where each transducer targets a single cell or a small number of cells. The conversion occurs on the same time scale as that carried out by the normal retina. In addition, aspects of the invention may be used with robotic or other mechanical devices, where processing of visual information is required. The encoders may be adjusted over time with aging or the progression of a disease.Type: GrantFiled: August 27, 2012Date of Patent: December 29, 2015Assignee: Cornell UniversityInventor: Sheila Nirenberg