Patents by Inventor Sheila P. Handattu

Sheila P. Handattu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic apolipoprotein E mimicking polypeptides and methods of use
    Patent number: 8557767
    Abstract: The present invention provides novel synthetic apolipoprotein E (ApoE)-mimicking peptides wherein the receptor binding domain of apolipoprotein E is covalently linked to 18A, the well characterized lipid-associating model class A amphipathic helical peptide, or a modified version thereof. Such peptides enhance low density lipoprotein (LDL) and very low density lipoprotein (VLDL) binding to and degradation by fibroblast or HepG2 cells. Also provided are possible applications of the synthetic peptides in lowering human plasma LDL/VLDL cholesterol levels, thus inhibiting atherosclerosis. The present invention also relates to synthetic peptides that can improve HDL function and/or exert anti-inflammatory properties.
    Type: Grant
    Filed: August 27, 2008
    Date of Patent: October 15, 2013
    Assignee: UAB Research Foundation
    Inventors: Gattadahalli M. Anantharamaiah, David W. Garber, Geeta Datta, Sheila P. Handattu, Vinod K. Mishra