Patents by Inventor Shekhar Bhirud
Shekhar Bhirud has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150018578Abstract: The present invention provides a process for preparation of fingolimod, a compound of Formula I or a pharmaceutically acceptable salt thereof, free of regioisomeric impurity compound of Formula IAType: ApplicationFiled: January 17, 2013Publication date: January 15, 2015Applicant: Glenmark Generics LimitedInventors: Milind Gharpure, Krishna Narawade, Prem Chand, Shekhar Bhirud
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Publication number: 20080071094Abstract: A process for preparing perindopril is provided comprising condensing an N-[(S)-1-carbethoxybutyl]-(S)-alanyl halide of formula II: wherein X is a halide with an (2S,3aS,7aS)-2-carboxyperhydroindole of formula III: wherein R is hydrogen or a protecting group.Type: ApplicationFiled: September 21, 2007Publication date: March 20, 2008Applicant: Glenmark Pharmaceuticals LimitedInventors: Narendra JOSHI, Shekhar BHIRUD, Kodali RAO, Buddhavarapu RAMAM, Vijay SONI
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Publication number: 20060281800Abstract: A process for the preparation of a novel crystalline polymorph of olmesartan medoxomil, designated Form G, is provided comprising the steps of (a) preparing a solution comprising olmesartan medoxomil and one or more solvents selected from the group consisting of a nitrile, alcohol and mixtures thereof at a suitable temperature to obtain a solution; and (b) recovering olmesartan medoxomil substantially in polymorph Form G from the solution. A novel polymorph Form G of olmesartan medoxomil and pharmaceutical compositions containing same are also provided herein.Type: ApplicationFiled: April 12, 2006Publication date: December 14, 2006Applicant: Glenmark Pharmaceuticals LimitedInventors: Bobba Venkata Kumar, Girish Patel, Nitin Sharad Pradhan, Shekhar Bhirud
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Publication number: 20060211866Abstract: A process for the preparation of a biphenyl-containing compound of general formula I: wherein R1 is a C3-6 carbonyl containing compound; R2 is a substituted or unsubstituted, straight or branched C3-6 alkyl group, or R1 and R2 together with the nitrogen atom to which they are bonded are joined together to form a substituted heterocyclic group selected from the group consisting of substituted or unsubstituted imidazoles, substituted or unsubstituted benzimidazoles and substituted or unsubstituted 1,3-diazaspiro[4,4]non-1-en-4-one; and R3 is a carboxylic acid ester, cyano, a substituted or unsubstituted 1H-tetrazolyl group or a substituted or unsubstituted group which may be converted in vivo into a carboxy group is provided, the process comprising reacting a compound of general formula II: wherein R1 and R2 have the aforestated meanings with a compound of general formula III: wherein Z is a leaving group and R3 has the aforestated meaning in a biphasic solvent system in the presence of a phase traType: ApplicationFiled: March 21, 2006Publication date: September 21, 2006Applicant: Glenmark Pharmaceuticals LimitedInventors: Narendra Joshi, Kodali Rao, Buddhavarapu Ramam, Shekhar Bhirud
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Publication number: 20060211867Abstract: A process for preparing perindopril is provided comprising condensing an N-[(S)-1-carbethoxybutyl]-(S)-alanyl halide of formula II: wherein X is a halide with an (2S,3aS,7aS)-2-carboxyperhydroindole of formula III: wherein R is hydrogen or a protecting group.Type: ApplicationFiled: March 21, 2006Publication date: September 21, 2006Applicant: Glenmark Pharmaceuticals LimitedInventors: Narendra Joshi, Shekhar Bhirud, Kodali Rao, Buddhavarapu Ramam, Vijay Soni
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Publication number: 20060189670Abstract: A process for the preparation of anastrozole is provided, the process comprising: (a) reacting 3,5-bis(1-cyano-1-methylethyl)benzyl halide with a 4-Z-1,2,4-triazole compound of the formula wherein Z is a protecting group to produce 2,2?-[5-(4-Z-1,2,4-triazolium-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile) halide; and (b) deprotecting the 2,2?-[5-(4-Z-1,2,4-triazolium-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile)halide to produce anastrozole. Also provided is anastrozole substantially free of its isomers.Type: ApplicationFiled: February 22, 2006Publication date: August 24, 2006Applicant: Glenmark Pharmaceuticals LimitedInventors: Anil Khile, Narendra Joshi, Shekhar Bhirud
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Publication number: 20060111560Abstract: A process for preparing Form II crystals of clarithromycin is provided comprising (a) treating clarithromycin with a carboxylic acid in an organic solvent to provide a clarithromycin acid salt; and, (b) heating the clarithromycin acid salt at a temperature capable of providing Form II crystals of clarithromycin.Type: ApplicationFiled: November 1, 2005Publication date: May 25, 2006Applicant: Glenmark Pharmaceuticals LimitedInventors: Bobba Kumar, Changdev Raut, Shekhar Bhirud
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Publication number: 20060106233Abstract: A process for the preparation of a disubstituted acetylene bearing heteroaromatic and heterobicyclic groups of formula I is provided wherein X is S, O, or NR1 wherein R1 is hydrogen or a C1-C6 straight or branched alkyl group; R is hydrogen or a C1-C6 straight or branched alkyl group; A is a substituted or unsubstituted pyridinyl, thienyl, furyl, pyridazinyl, pyrimidinyl or pyrazinyl group; n is 0-4; and B is H, —COOH, —CH2OH, —CHO or a C1-C6 alkyl acetal derivative, —COR2 or a C1-C6 alkyl ketal derivative where R2 is —(CH2)mCH3 where m is 0-4 or COOR3 wherein R3 is a straight or branched C1-C30 alkyl group, a substituted or unsubstituted C6-C30 aromatic group, a substituted or unsubstituted C3-C30 cycloalkyl, a substituted or unsubstituted C3-C30 cycloalkylalkyl, a substituted or unsubstituted C3-C30 cycloalkenyl, a substituted or unsubstituted C5-C30 aryl, a substituted or unsubstituted C5-C30 arylalkyl, a substituted or unsubstituted C5-C30 heteroaryl, a substituted or unsubstituted C3-C30 heterocycliType: ApplicationFiled: June 17, 2005Publication date: May 18, 2006Applicant: Glenmark Pharmaceuticals LimitedInventors: Bobba Kumar, Shekhar Bhirud, Batchu Chandrasekhar, Changdev Raut
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Publication number: 20060084806Abstract: A process for the preparation of imidazo[1,2-a]pyridine derivatives of the formula I: wherein R is hydrogen, halogen or a C1-C4 alkyl group; R1 and R2 are independently hydrogen, a straight or branched C1-C6 alkyl group which is unsubstituted or substituted by one or more halogen atoms, hydroxyl, N(C1-C4 alkyl)2, carbamoyl or C1-C4 alkoxy radicals, a C1-C6 alkyl hydroxy group, a C3-C6 cycloalkyl radical, a benzyl radical, a phenyl radical or R1 and R2 together with the nitrogen atom to which they are bonded are joined together to form a substituted or unsubstituted heterocyclic group optionally containing one or more additional heterocyclic atoms; and R3 and R4 are independently hydrogen, halogen or a C1-C4 alkyl group, or a pharmaceutically acceptable salt thereof, the process comprising (a) reacting an imidazo[1,2-a]pyridine carboxylic acid of the formula II wherein R, R3 and R4 have the aforestated meanings with a halogenating agent in the absence of a solvent to form an acid halide intermediate aType: ApplicationFiled: July 21, 2005Publication date: April 20, 2006Inventors: Ramasubramanian Sridharan, Shekhar Bhirud, Vandanapu Purushotham
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Publication number: 20060084814Abstract: The present invention provides an improved process for the preparation of zonisamide or a derivative thereof comprising (a) reacting 1,2-benzisoxazole-3-methane-sulfonic acid with a halogenating agent in a first organic solvent to provide benzisoxazole methane sulfonyl halide; and, (b) reacting benzisoxazole methane sulfonyl halide with an amine in a second organic solvent to form zonisamide or a derivative thereof.Type: ApplicationFiled: May 20, 2005Publication date: April 20, 2006Inventors: Bobba Siva Kumar, Shekhar Bhirud, Batchu Chandrasekhar, Sanjay Kale
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Publication number: 20060079698Abstract: A process for the preparation of an intermediate of trandolapril, (2S,3aR,7aS)-perhydroindole-2-carboxylic acid of Formula II is provided. Also provided are processes for preparing trandolapril.Type: ApplicationFiled: October 7, 2005Publication date: April 13, 2006Applicant: Glenmark Pharmaceuticals LimitedInventors: Narendra Joshi, Shekhar Bhirud, Buddhavarapu Ramam, Arjun Bodkhe
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Publication number: 20050282878Abstract: The present invention relates to processes for the purification of crude fluconazole including at least a first leaching, a second leaching, and an acid/base treatment and to highly purified fluconazole produced from the processes.Type: ApplicationFiled: April 12, 2005Publication date: December 22, 2005Inventors: Batchu Chandrasekhar, Ramasubramanian Sridharan, Biju Kumar Gopinathen Pillai, Shekhar Bhirud
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Publication number: 20050250706Abstract: Processes for the preparation of an alpha polymorph of perindopril erbumine is provided comprising (a) forming a solution comprising perindopril erbumine in one or more ketones; (b) heating the solution to reflux; and (c) cooling the solution to a temperature sufficient to form the alpha polymorph of perindopril erbumine. The alpha polymorphs of perindopril erbumine obtained herein have a high purity level.Type: ApplicationFiled: May 5, 2005Publication date: November 10, 2005Applicant: Glenmark Pharmaceuticals LimitedInventors: Narendra Joshi, Shekhar Bhirud, Kodali Rao
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Publication number: 20050239885Abstract: Improved processes for the preparation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) inhibitors, e.g., simvastatin, and their intermediates are provided. In one embodiment, a process for the preparation of a carboxylic acid amine salt of formula I is provided wherein R1 and R2 are as defined herein, the process comprising reacting lovastatin with an amine of formula III: in an aqueous medium to provide the carboxylic acid amine salt of formula I. The process further includes the steps of lithiating the carboxylic acid amine salt of formula I to form the corresponding 2,2-dimethylbutyrate intermediate of formula IIa lactonizing the 2,2-dimethylbutyrate intermediate (IIa) to provide simvastatin and pharmaceutically acceptable salts thereof. Also provided is an improved process for lactonization of the intermediates herein using peptide coupling reagents.Type: ApplicationFiled: April 22, 2005Publication date: October 27, 2005Applicant: Glenmark Pharmaceuticals LimitedInventors: Narendra Joshi, Shekhar Bhirud, Kodali Rao
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Publication number: 20050240029Abstract: An improved process for the preparation of key intermediates for tazarotene, 4,4-dimethyl-6-ethynylthiochroman, is provided comprising (a) reacting 4,4-dimethyl-6-acetylthiochroman of the formula with an acid chloride and an amido-group containing compound of the general formula wherein R is hydrogen or a hydrocarbyl of from 1 to 15 carbon atoms and R1 and R2 can be the same or different and are hydrocarbyls of from 1 to 15 carbon atoms or R1 and R2 together with the nitrogen atom to which they are bonded are joined together to form a heterocyclic group, optionally containing one or more additional heterocyclic atoms, or one of R1 and R2 together with the nitrogen atom to which it bonded are joined together with the carbonyl radical to form a heterocyclic group, optionally containing one or more additional heterocyclic atoms to form a chloro vinyl carbonyl compound intermediate of the general formula wherein R has the aforestated meanings; and (b) reacting the ?-chloro vinyl carbonyl compound inteType: ApplicationFiled: June 22, 2005Publication date: October 27, 2005Applicant: Glenmark Pharmaceuticals LimitedInventors: Bobba Venkata Kumar, Vishvas Patil, Changdev Raut, Shekhar Bhirud, Batchu Chandrasekhar
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Publication number: 20050203287Abstract: An improved process for the preparation of sulfamate derivatives such as topiramate is provided comprising (a) reacting an alcohol with sulfuryl chloride in the presence of an amine base and in a first halogenated hydrocarbon solvent selected from the group consisting of aliphatic halogenated hydrocarbon solvents having 1 to 12 carbon atoms and at least three halogen atoms, aliphatic halogenated hydrocarbon solvents having 2 to 12 carbon atoms and less than three halogen atoms, aromatic halogenated hydrocarbon solvents having 6 to 18 carbon atoms and mixtures thereof to produce a chlorosulfate intermediate and (b) reacting the chlorosulfate intermediate with an amine of the formula R1NH2, wherein R1 is hydrogen or an alkyl from 1 to 4 carbon atoms, in a second halogenated hydrocarbon solvent selected from the group consisting of aliphatic halogenated hydrocarbon solvents having 1 to 12 carbon atoms and at least three halogen atoms, aliphatic halogenated hydrocarbon solvents having 2 to 12 carbon atoms and lesType: ApplicationFiled: March 11, 2005Publication date: September 15, 2005Inventors: Chandrasekhar Batchu, Biju Kumar Pillai, Shekhar Bhirud
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Publication number: 20050203297Abstract: A process for preparing 5H-dibenz[b,f]azepine-5-carboxamide of the general formula: wherein R1, R2, R3 and R4 are the same or different and can be hydrogen, halogen, nitro, cyano, carboxyl, R, —CO(R), —OCO(R), —O(R), —N(R)2, —CON(R)2, and —COO(R), wherein R is selected from the group consisting of C1-C10 alkyl, C3-C10 cycloalkyl, C2-C10 alkenyl, C5-C10 cycloalkenyl, C2-C10 alkynyl, and C6-C20 aryl, wherein the two A groups of —N(A)2 and —CON(A)2 can be the same or different, and wherein R2 and R3 can together form a bond is provided; the process comprising reacting 5H-dibenz[b,f]azepine of the general formula wherein R1, R2, R3 and R4 have the aforementioned meanings, with one or more alkali or alkaline-earth cyanates and in the presence of one or more unsaturated dicarboxylic acids.Type: ApplicationFiled: March 11, 2005Publication date: September 15, 2005Inventors: Bobba Sivakumar, Shekhar Bhirud, Chandrasekhar Batchu, Sanjay Kale
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Publication number: 20050171165Abstract: A process for preparing a novel intermediate in the preparation of perindopril is provided.Type: ApplicationFiled: November 10, 2004Publication date: August 4, 2005Inventors: Shekhar Bhirud, Suhail Ahmed, Batchu Chandrasekhar, Vandanapu Loka Purushotham
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Publication number: 20050124639Abstract: An improved process for the preparation of pyrimidine derivatives is provided comprising reacting a Wittig reagent of the general formula wherein R is an alkyl of from 1 to 10 carbon atoms, aryl or arylalkyl, R1 is a substituted or unsubstituted hydrocarbon group, R2 and R3 are the same or different and are hydrogen or a substituted or unsubstituted hydrocarbon group; Z is sulfur, oxygen, sulfonyl, or imino which may be substituted by formyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, amino substituted by sulfonyl or alkylsulfonyl, and sulfonyl substituted by alkyl, amino or alkylamino and X is a halogen; with an aldehyde of the general formula wherein R4 is hydrogen, a lower alkyl or a cation capable of forming a non-toxic pharmaceutically acceptable salt and each R5 are the same or different and are hydrogen or a hydrolyzable protecting group, or each R5, together with the oxygen atom to which each is bonded, form a hydrolyzable cyclic protecting group, or each R5 is bonded to theType: ApplicationFiled: December 3, 2004Publication date: June 9, 2005Inventors: Narendra Joshi, Shekhar Bhirud, Batchu Chandrasekhar, K. Rao, Subhash Damle
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Publication number: 20050004373Abstract: An improved process for the preparation of key intermediates for tazarotene, 4,4-dimethyl-6-ethynylthiochroman, is provided comprising (a) reacting 4,4-dimethyl-6-acetylthiochroman of the formula with an acid chloride and an amido-group containing compound of the general formula wherein R is hydrogen or a hydrocarbyl of from 1 to 15 carbon atoms and R1 and R2 can be the same or different and are hydrocarbyls of from 1 to 15 carbon atoms or R1 and R2 together with the nitrogen atom to which they are bonded are joined together to form a heterocyclic group, optionally containing one or more additional heterocyclic atoms, or one of R1 and R2 together with the nitrogen atom to which it bonded are joined together with the carbonyl radical to form a heterocyclic group, optionally containing one or more additional heterocyclic atoms to form a ?-chloro vinyl carbonyl compound intermediate of the general formula wherein R has the aforestated meanings; and (b) reacting the ?-chloro vinyl carbonyl compound inType: ApplicationFiled: July 2, 2004Publication date: January 6, 2005Inventors: Bobba Kumar, Vishvas Patil, Changdev Raut, Shekhar Bhirud, Batchu Chandrasekhar