Abstract: Fluid delivery devices for delivering therapeutic agents are described. More particularly, this disclosure relates to drug reconstitution devices having a plurality of components movable with respect to one another such that an active agent and a solvent can be reconstituted within the device prior to injection. The fluid delivery devices can include a housing, a cartridge holder, a cartridge disposed within the cartridge holder, a button rod, and a foot. The cartridge stores the active agent and the solvent, which are separated by one or more stoppers. The button rod and foot can provide an axial force upon the stopper(s) in the cartridge to inject the fluid once reconstituted. The foot and the button rod can be separate components, thereby enabling the foot to rotate independently with respect to the button rod as the cartridge holder is rotated to reconstitute the therapeutic and prime the device for injection.

Abstract: A reusable tip for minimally invasive surgical instruments can include an end effector, a two-part hub, and a yoke. The end effector can include one or more movable portions enabling the end effector to move between first (e.g., open) and second (e.g., closed) positions via manipulation of the yoke within the hub. The hub can include a proximal hub and a distal hub coupled together. The end effector can be coupled to the distal hub, which can be made of a metal to provide high strength and secure shape to the distal hub. The proximal hub can be made of an autoclavable insulation material capable of maintaining a removable coupling with a control shaft. The proximal hub can be made of polyetheretherketone (PEEK).

Abstract: A reusable tip for minimally invasive surgical instruments can include an end effector, a two-part hub, and a yoke. The end effector can include one or more movable portions enabling the end effector to move between first (e.g., open) and second (e.g., closed) positions via manipulation of the yoke within the hub. The hub can include a proximal hub and a distal hub coupled together. The end effector can be coupled to the distal hub, which can be made of a metal to provide high strength and secure shape to the distal hub. The proximal hub can be made of an autoclavable insulation material capable of maintaining a removable coupling with a control shaft. The proximal hub can be made of polyetheretherketone (PEEK).

Abstract: An electronic forceps system includes a handle including a pair of pivotable arms distally extending from a proximal end of the handle, at least one arm of the pair of arms having an electrically-conductive arm element connectable to a power source, wherein each arm of the pair of arms comprises a respective pair of arm interfaces, and the electrically-conductive arm element extends to at least one interface of the pair of interfaces. Also provided is a pair of tips, at least one tip of the pair of tips having an electrically-conductive tip element, wherein each tip has a tip interface configured to removably connect to a respective arm interface, each tip has a distal working surface, the electrically-conductive tip element is configured to removably and electrically connect to the electrically-conductive arm element, the electrically-conductive tip element is connected to a heater.

Abstract: An electronic forceps system includes a handle including a pair of pivotable arms distally extending from a proximal end of the handle, at least one arm of the pair of arms having an electrically-conductive arm element connectable to a power source, wherein each arm of the pair of arms comprises a respective pair of arm interfaces, and the electrically-conductive arm element extends to at least one interface of the pair of interfaces. Also provided is a pair of tips, at least one tip of the pair of tips having an electrically-conductive tip element, wherein each tip has a tip interface configured to removably connect to a respective arm interface, each tip has a distal working surface, the electrically-conductive tip element is configured to removably and electrically connect to the electrically-conductive arm element, the electrically-conductive tip element is connected to a heater.

Abstract: A reusable tip for minimally invasive surgical instruments can include an end effector, a two-part hub, and a yoke. The end effector can include one or more movable portions enabling the end effector to move between first (e.g., open) and second (e.g., closed) positions via manipulation of the yoke within the hub. The hub can include a proximal hub and a distal hub coupled together. The end effector can be coupled to the distal hub, which can be made of a metal to provide high strength and secure shape to the distal hub. The proximal hub can be made of an autoclavable insulation material capable of maintaining a removable coupling with a control shaft. The proximal hub can be made of polyetheretherketone (PEEK).

Abstract: An electronic forceps system includes a handle including a pair of pivotable arms distally extending from a proximal end of the handle, at least one arm of the pair of arms having an electrically-conductive arm element connectable to a power source, wherein each arm of the pair of arms comprises a respective pair of arm interfaces, and the electrically-conductive arm element extends to at least one interface of the pair of interfaces. Also provided is a pair of tips, at least one tip of the pair of tips having an electrically-conductive tip element, wherein each tip has a tip interface configured to removably connect to a respective arm interface, each tip has a distal working surface, the electrically-conductive tip element is configured to removably and electrically connect to the electrically-conductive arm element, the electrically-conductive tip element is connected to a heater.

Abstract: A system for registering images is provided. The system includes a first imaging device having an imager positioned at a distal end thereof. The first image device is configured to produce a first image of a body cavity. The system includes an imaging system having a second imaging device having an imager positioned at a distal end thereof and configured to be positioned approximate to said imager of said first imaging device within said body cavity and configured to produce a second image. An elongated member having an outer surface is molded to include imaging markers such that said imaging markers are embedded within the outer surface. At least one of the image markers is configured to produce registration information in the first image and the second image.

Abstract: A system for registering images is provided. The system includes a first imaging device having an imager positioned at a distal end thereof. The first image device is configured to produce a first image of a body cavity. The system includes an imaging system having a second imaging device having an imager positioned at a distal end thereof and configured to be positioned approximate to said imager of said first imaging device within said body cavity and configured to produce a second image. An elongated member having an outer surface is molded to include imaging markers such that said imaging markers are embedded within the outer surface. At least one of the image markers is configured to produce registration information in the first image and the second image.

Abstract: A mechanical tensioning device includes a housing including a passageway and an opening that is in communication with the passageway. A plunger is movably disposed in the passageway. A first end of the plunger includes an inner member. A connector is coupled to the housing and includes a channel that is in communication with the passageway and a port in communication with the channel. A catheter is coupled to the connector and includes a lumen that is in communication with the channel and an expandable member. The inner member extends through the lumen and into the expandable member such that a distal end of the inner member is fixed to a distal end of the expandable member. The inner member is moveable between a first configuration in which the inner member is curved within the expandable member and a second configuration in which the inner member is less curved within the expandable member.

Abstract: A surgical system is provided that includes a sleeve having an inner surface defining a first channel that extends along a first longitudinal axis and an inner surface defining a second channel that extends along a second longitudinal axis. The second channel is spaced apart from the first channel. A first surgical instrument is configured for disposal in the first channel. The first surgical instrument includes an optical probe configured for imaging. A second surgical instrument is configured for disposal in the second channel. The second surgical instrument includes an inflatable balloon. Methods and kits are also provided.

Abstract: An endoscope support device is provided. The device includes a sleeve extending along a longitudinal axis between a first end and a second end. The sleeve includes an inner surface defining a passageway configured for disposal of an endoscope. An end surface of the distal end is spaced from external surroundings by a wall that defines the end surface. A center piece is disposed within the passageway. The center piece includes a first end that engages the end wall and an inner surface defining a lumen configured for disposal of an optical probe. The center piece is positioned within the passageway such that the lumen of the center piece is aligned with a lumen of the endoscope and the probe extends through the lumens. Systems, kits and methods are also provided.

Abstract: Methods and apparatus are disclosed for inserting flexible, multi-lumen catheters into blood vessels, and in particular, for inserting flexible, split-tip catheters into blood vessels. The invention accomplishes these objects by temporarily stiffening each catheter lumen and tip independently through use of intra-catheter stiffener elements disposed within the catheter lumens. This provides means for advancing the catheter/stiffeners assembly through a subcutaneous tunnel, and over a plurality of guidewires until a distal tip of the catheter is at a desired position within the vessel. The intra-catheter stiffener elements are sufficiently stiffening to allow advancing the catheter over guidewires, but sufficiently flexible to allow bending and looping of the catheter for proper placement within the vessel.

Abstract: Methods and apparatus are disclosed for inserting flexible, multi-lumen catheters into blood vessels, and in particular, for inserting flexible, split-tip catheters into blood vessels. The invention accomplishes these objects by temporarily stiffening each catheter lumen and tip independently through use of intra-catheter stiffener elements disposed within the catheter lumens. This provides means for advancing the catheter/stiffeners assembly through a subcutaneous tunnel, and over a plurality of guidewires until a distal tip of the catheter is at a desired position within the vessel. The intra-catheter stiffener elements are sufficiently stiffening to allow advancing the catheter over guidewires, but sufficiently flexible to allow bending and looping of the catheter for proper placement within the vessel.

Abstract: Methods and apparatus are disclosed for inserting flexible, multi-lumen catheters into blood vessels, and in particular, for inserting flexible, split-tip catheters into blood vessels. The invention accomplishes these objects by temporarily stiffening each catheter lumen and tip independently through use of intra-catheter stiffener elements disposed within the catheter lumens. This provides means for advancing the catheter/stiffeners assembly through a subcutaneous tunnel, and over a plurality of guidewires until a distal tip of the catheter is at a desired position within the vessel. The intra-catheter stiffener elements are sufficiently stiffening to allow advancing the catheter over guidewires, but sufficiently flexible to allow bending and looping of the catheter for proper placement within the vessel.