Patents by Inventor Shelby Marie KING

Shelby Marie KING has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of engineered renal tissues in assays
    Patent number: 11982668
    Abstract: Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent renal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of assessing the effect of an agent on renal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are models of renal disorder. In one embodiment, disclosed are models of renal fibrosis, comprising a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of making the model of renal disorder. In one embodiment disclosed are methods of making the model of renal fibrosis comprising contacting a three-dimensional, engineered, bioprinted, biological renal tubule model with an agent that is capable of inducing interstitial fibrotic tissue formation.
    Type: Grant
    Filed: January 26, 2022
    Date of Patent: May 14, 2024
    Assignee: Organovo, Inc.
    Inventors: Shelby Marie King, Deborah Lynn Greene Nguyen, Sharon C. Presnell
  • Engineered renal tissues, arrays thereof, and methods of making the same
    Patent number: 11867689
    Abstract: Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.
    Type: Grant
    Filed: March 25, 2021
    Date of Patent: January 9, 2024
    Assignee: ORGANOVO, INC.
    Inventors: Deborah Lynn Greene Nguyen, Shelby Marie King, Sharon C. Presnell
  • Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model
    Patent number: 11789011
    Abstract: Described are three-dimensional, engineered, biological breast tissues, adipose tissues, and tumor models, including breast cancer models.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: October 17, 2023
    Inventors: Shelby Marie King, Deborah Lynn Greene Nguyen, Vivian A. Gorgen, Benjamin R. Shepherd, Sharon C. Presnell, Rosalie Sears, Brittany Allen-Petersen, Ellen Langer
  • Use of Engineered Renal Tissues in Assays
    Publication number: 20220229045
    Abstract: Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent renal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of assessing the effect of an agent on renal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are models of renal disorder. In one embodiment, disclosed are models of renal fibrosis, comprising a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of making the model of renal disorder. In one embodiment disclosed are methods of making the model of renal fibrosis comprising contacting a three-dimensional, engineered, bioprinted, biological renal tubule model with an agent that is capable of inducing interstitial fibrotic tissue formation.
    Type: Application
    Filed: January 26, 2022
    Publication date: July 21, 2022
    Applicant: Organovo, Inc.
    Inventors: Shelby Marie KING, Deborah Lynn Greene NGUYEN, Sharon C. PRESNELL
  • METHODS FOR TISSUE FABRICATION
    Publication number: 20220195380
    Abstract: Disclosed herein are improved methods for fabricating bioprinted, three-dimensional, biological tissues. The methods relate to exposures to low temperatures, incubations at low temperatures of various durations, and fabrication in environments without structural cross-linking treatments.
    Type: Application
    Filed: October 1, 2021
    Publication date: June 23, 2022
    Inventors: Kelsey Nicole RETTING, Deborah Lynn Greene NGUYEN, Sharon C. PRESNELL, Shelby Marie KING
  • Use of engineered renal tissues in assays
    Patent number: 11268950
    Abstract: Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent renal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of assessing the effect of an agent on renal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are models of renal disorder. In one embodiment, disclosed are models of renal fibrosis, comprising a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of making the model of renal disorder. In one embodiment disclosed are methods of making the model of renal fibrosis comprising contacting a three-dimensional, engineered, bioprinted, biological renal tubule model with an agent that is capable of inducing interstitial fibrotic tissue formation.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: March 8, 2022
    Assignee: Organovo, Inc.
    Inventors: Shelby Marie King, Deborah Lynn Greene Nguyen, Sharon C. Presnell
  • Engineered Renal Tissues, Arrays Thereof, and Methods of Making the Same
    Publication number: 20210208132
    Abstract: Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.
    Type: Application
    Filed: March 25, 2021
    Publication date: July 8, 2021
    Inventors: Deborah Lynn Greene NGUYEN, Shelby Marie KING, Sharon C. PRESNELL
  • Engineered renal tissues, arrays thereof, and methods of making the same
    Patent number: 10962526
    Abstract: Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: March 30, 2021
    Assignee: Organovo, Inc.
    Inventors: Deborah Lynn Greene Nguyen, Shelby Marie King, Sharon C. Presnell
  • Engineered Three-Dimensional Breast Tissue, Adipose Tissue, and Tumor Disease Model
    Publication number: 20200116702
    Abstract: Described are three-dimensional, engineered, biological breast tissues, adipose tissues, and tumor models, including breast cancer models.
    Type: Application
    Filed: December 12, 2019
    Publication date: April 16, 2020
    Inventors: Shelby Marie KING, Deborah Lynn Greene NGUYEN, Vivian A. GORGEN, Benjamin R. SHEPHERD, Sharon C. PRESNELL, Rosalie SEARS, Brittany ALLEN-PETERSEN, Ellen LANGER
  • Use of Engineered Renal Tissues in Assays
    Publication number: 20200018747
    Abstract: Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent renal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of assessing the effect of an agent on renal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are models of renal disorder. In one embodiment, disclosed are models of renal fibrosis, comprising a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of making the model of renal disorder. In one embodiment disclosed are methods of making the model of renal fibrosis comprising contacting a three-dimensional, engineered, bioprinted, biological renal tubule model with an agent that is capable of inducing interstitial fibrotic tissue formation.
    Type: Application
    Filed: September 28, 2017
    Publication date: January 16, 2020
    Applicant: Organovo, Inc.
    Inventors: Shelby Marie KING, Deborah Lynn Greene NGUYEN, Sharon C. PRESNELL
  • Three Dimensional Bioprinted Tumor Models for Drug Testing
    Publication number: 20190309264
    Abstract: Described are three-dimensional, engineered, biological cancer models, methods of producing the same, and methods of identifying a therapeutic agent for cancer in an individual utilizing the three-dimensional, engineered, biological cancer models.
    Type: Application
    Filed: August 15, 2017
    Publication date: October 10, 2019
    Inventors: Sharon C. PRESNELL, Shelby Marie KING, Deborah Lynn Greene NGUYEN, Minji JO, Rosalie Sears PELZ, Brittany ALLEN-PETERSEN, Ellen LANGER
  • Engineered Renal Tissues, Arrays Thereof, and Methods of Making the Same
    Publication number: 20190041381
    Abstract: Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.
    Type: Application
    Filed: October 8, 2018
    Publication date: February 7, 2019
    Inventors: Deborah Lynn Greene NGUYEN, Shelby Marie KING, Sharon C. PRESNELL
  • Engineered renal tissues, arrays thereof, and methods of making the same
    Patent number: 10094821
    Abstract: Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: October 9, 2018
    Assignee: Organovo, Inc.
    Inventors: Deborah Lynn Greene Nguyen, Shelby Marie King, Sharon C. Presnell
  • Improved Methods for Tissue Fabrication
    Publication number: 20180265839
    Abstract: Disclosed herein are improved methods for fabricating bioprinted, three-dimensional, biological tissues. The methods relate to exposures to low temperatures, incubations at low temperatures of various durations, and fabrication in environments without structural cross-linking treatments.
    Type: Application
    Filed: November 9, 2016
    Publication date: September 20, 2018
    Inventors: Kelsey Nicole RETTING, Deborah Lynn Greene NGUYEN, Sharon C. PRESNELL, Shelby Marie KING
  • Engineered Three-Dimensional Breast Tissue, Adipose Tissue, and Tumor Disease Model
    Publication number: 20180196034
    Abstract: Described are three-dimensional, engineered, biological breast tissues, adipose tissues, and tumor models, including breast cancer models.
    Type: Application
    Filed: March 5, 2018
    Publication date: July 12, 2018
    Inventors: Shelby Marie KING, Deborah Lynn Greene Nguyen, Vivian A. Gorgen, Benjamin R. Shepherd, Sharon C. Presnell, Rosalie Sears, Brittany Allen-Petersen, Ellen Langer
  • Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model
    Patent number: 9983195
    Abstract: Described are three-dimensional, engineered, biological breast tissues, adipose tissues, and tumor models, including breast cancer models.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: May 29, 2018
    Assignee: Organovo, Inc.
    Inventors: Shelby Marie King, Deborah Lynn Greene Nguyen, Vivian A. Gorgen, Benjamin R. Shepherd, Sharon C. Presnell
  • Engineered Renal Tissues, Arrays Thereof, and Methods of Making The Same
    Publication number: 20170131264
    Abstract: Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.
    Type: Application
    Filed: September 8, 2016
    Publication date: May 11, 2017
    Inventors: Deborah Lynn Greene NGUYEN, Shelby Marie KING, Sharon C. PRESNELL
  • METHODS FOR TISSUE FABRICATION
    Publication number: 20170130192
    Abstract: Disclosed herein are improved methods for fabricating bioprinted, three-dimensional, biological tissues. The methods relate to exposures to low temperatures, incubations at low temperatures of various durations, and fabrication in environments without structural cross-linking treatments.
    Type: Application
    Filed: November 9, 2015
    Publication date: May 11, 2017
    Inventors: Kelsey Nicole RETTING, Deborah Lynn Greene NGUYEN, Sharon C. PRESNELL, Shelby Marie KING
  • ENGINEERED THREE-DIMENSIONAL BREAST TISSUE, ADIPOSE TISSUE, AND TUMOR DISEASE MODEL
    Publication number: 20170023550
    Abstract: Described are three-dimensional, engineered, biological breast tissues, adipose tissues, and tumor models, including breast cancer models.
    Type: Application
    Filed: June 6, 2014
    Publication date: January 26, 2017
    Inventors: Shelby Marie King, Deborah Lynn Greene Nguyen, Vivian A. Gorgen, Benjamin R. Shepherd, Sharon c. Presnell, Rosalie Sears, Brittany Allen-Petersen, Ellen Langer
  • Engineered renal tissues, arrays thereof, and methods of making the same
    Patent number: 9481868
    Abstract: Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: November 1, 2016
    Assignee: Organovo, Inc.
    Inventors: Deborah Lynn Greene Nguyen, Shelby Marie King, Sharon C. Presnell