Patents by Inventor Sheldon B. Zimmerman

Sheldon B. Zimmerman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antifungal fermentation product
    Patent number: 5008187
    Abstract: A new antifungal agent which exhibits a moderately broad spectrum of activity towards filamentous fungi and also against Cryptococcus species of the yeast fungi, and which has been isolated from a solid stationary fermentation of an unidentified species of Fusarium is described.
    Type: Grant
    Filed: December 1, 1988
    Date of Patent: April 16, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Louis Chaiet, Sheldon B. Zimmerman, Richard L. Monaghan, George M. Garrity
  • L-654,040, antibacterial agent
    Patent number: 4963569
    Abstract: L-654,040 of the structure: ##STR1## is a novel antibacterial and isolated from the novel organism Streptoverticillium synroense, strain MA6011, deposited at the ATCC.
    Type: Grant
    Filed: June 9, 1989
    Date of Patent: October 16, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Sara A. Currie, Thomas W. Miller, Eugene L. Dulaney, James P. Springer, Mary E. Valiant, Sagrario Mochales del Val, Sheldon B. Zimmerman
  • Process for producing L-654,040, antibacterial agent
    Patent number: 4960698
    Abstract: L-654,040 of the structure: ##STR1## is a novel antibacterial and isolated from the novel organism Streptoverticillium synroense, strain MA6011, deposited at the ATCC.
    Type: Grant
    Filed: May 9, 1989
    Date of Patent: October 2, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Sara A. Currie, Thomas W. Miller, Eugene L. Dulaney, James P. Springer, Mary E. Valiant, Sagrario M. del Val, Sheldon B. Zimmerman
  • Culture of Streptoverticillium synroense for producing an antibacterial
    Patent number: 4956294
    Abstract: The novel organism Streptoverticillium synroense, strain MA6011, deposited at the ATCC under Accession No.
    Type: Grant
    Filed: May 9, 1989
    Date of Patent: September 11, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Sara A. Currie, Thomas W. Miller, Eugene L. Dulaney, James P. Springer, Mary E. Valiant, Sheldon B. Zimmerman, Sagrario M. Del Val
  • Antifugal tri-yne carbonates
    Patent number: 4806565
    Abstract: The invention relates to a novel tri-yne carbonate of formula I. Such compound can be produced by isolating it from the fermentation broth of ATCC-53614, ATCC-53615 OR ATCC-53616. The tri-yne carbonate has antifungal activity.
    Type: Grant
    Filed: May 26, 1987
    Date of Patent: February 21, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Otto D. Hensens, August J. Kempf, Robert E. Schwartz, Ruth S. Sykes, Carol F. Wichmann, Kenneth E. Wilson, Sheldon B. Zimmerman, Deborah L. Zink
  • Anti-gram positive bacteria tri-yne carbonates
    Patent number: 4806566
    Abstract: The invention relates to the tri-yne carbonate of formula I which has activity against gram positive bacteria. Such compound can be produced by isolating it from the fermentation broth of ATCC-53614, ATCC-53615 or ATCC-53616.
    Type: Grant
    Filed: May 26, 1987
    Date of Patent: February 21, 1989
    Assignee: Merck & Co., Inc.
    Inventor: Sheldon B. Zimmerman
  • Process for the preparation of difficidin and derivative antibacterials
    Patent number: 4681846
    Abstract: Process for the preparation of difficidin and derivative antibacterial compounds of the formula: ##STR1## where R.sub.a and R.sub.b are members independently selected from the group consisting of hydrogen; alkali metal and alkaline earth metal cations; ammonium; and substituted ammonium; and R.sup.1 is hydrogen or hydroxy.
    Type: Grant
    Filed: May 6, 1985
    Date of Patent: July 21, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth E. Wilson, Richard L. Monaghan, Cheryl DeRiso, Sheldon B. Zimmerman, Otto D. Hensens, James E. Flor, Sagrario M. Del Val, Maria I. M. Fernandez
  • R-(Z)-4-amino-3-chloro-2-pentenedioic acid, novel antibacterial agent
    Patent number: 4670466
    Abstract: R-(Z)-4-amino-3-chloro-2-pentenedioic acid is a novel antibacterial and isolated from Streptomyces viridogenes MA5450, ATCC 39387.
    Type: Grant
    Filed: September 20, 1985
    Date of Patent: June 2, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Louis Chaiet, Sheldon B. Zimmerman, Richard L. Monaghan, Maria I. Martin
  • Antibiotics Tejeramycin and production thereof
    Patent number: 4656036
    Abstract: The antibiotics Tejeramycin are active against gram negative and gram positive infections, especially against Pseudomonas aeruginosa. The antibiotics Tejeramycin are produced by the aerobic fermentation of Streptomyces griseus ATCC No. 39208 or 39209 in an assimilable aqueous nutrient medium.
    Type: Grant
    Filed: January 11, 1985
    Date of Patent: April 7, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth E. Wilson, Sheldon B. Zimmerman
  • R-(Z)-4-amino-3-chloro-2-pentenedioic acid, novel antibacterial agent
    Patent number: 4600691
    Abstract: R-(Z)-4-amino-3-chloro-2-pentenedioic acid is a novel antibacterial and isolated from Streptomyces viridogenes MA5450, ATCC 39387.
    Type: Grant
    Filed: April 3, 1985
    Date of Patent: July 15, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Louis Chaiet, Richard L. Monaghan, Sheldon B. Zimmerman, Maria I. M. Fernandez
  • Difficidin and derivative antibacterials
    Patent number: 4545991
    Abstract: Difficidin and derivative antibacterial compounds of the formula: ##STR1## where R.sub.a and R.sub.b are members independently selected from the group consisting of hydrogen; alkali metal and alkaline earth metal cations; ammonium; and substituted ammonium; and R.sup.1 is hydrogen or hydroxy.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: October 8, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Sheldon B. Zimmerman, Kenneth E. Wilson, Richard L. Monaghan, Sagrario M. Del Val, Maria I. M. Fernandez, Otto D. Hensens, James E. Flor, Cheryl Deriso
  • Discovery of antibiotic L-681,217 in fermentation broth
    Patent number: 4476139
    Abstract: The antibiotic, L-681,217, having antibacterial and growth-permittant activity, is produced by fermentation of Streptomyces cattleya in a suitable nutrient media.
    Type: Grant
    Filed: September 29, 1982
    Date of Patent: October 9, 1984
    Assignee: Merck & Co., Inc.
    Inventors: August J. Kempf, Kenneth E. Wilson, Otto D. Hensens, Richard L. Monaghan, Sheldon B. Zimmerman, Eugene L. Dulaney
  • Discovery of MSD A63A, a new efrotomycin-line antibiotic fermentation broth
    Patent number: 4311693
    Abstract: The antibiotic MSD A63A, having antibacterial and growth-permittant activity, is produced by fermentation of Streptoverticillum hiroshimense MA4845 (ATCC 31586), in a suitable nutrient media.
    Type: Grant
    Filed: November 17, 1980
    Date of Patent: January 19, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Sebastian Hernandez, Sheldon B. Zimmerman, Vincent P. Gullo, Ray S. Dewey
  • Process for producing A73A, a new Efrotomycin-like antibiotic in fermentation broth
    Patent number: 4304859
    Abstract: There is disclosed a new antibiotic agent, A73A, produced by Streptomyces viridifaciens MA-4864 (ATCC 31495) under suitable conditions. Said antibiotic shows antibacterial and growth-permittant activity.
    Type: Grant
    Filed: October 27, 1980
    Date of Patent: December 8, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Ray S. Dewey, James E. Flor, Sheldon B. Zimmerman, Patrick J. Cassidy, Satoshi Omura, Ruiko Oiwa
  • A40A Efrotomycin-like antibiotic in fermentation broth
    Patent number: 4264607
    Abstract: There is disclosed a new antibiotic agent, A40A, produced by Streptomyces lavedulae MA-4758 (ATCC 31312) under suitable conditions. Said antibiotic shows antibacterial and growth-permittant activity.
    Type: Grant
    Filed: September 13, 1979
    Date of Patent: April 28, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Ray S. Dewey, Vincent P. Gulla, Sheldon B. Zimmerman, Satoshi Omura, Ruiko Oiwa
  • Antibiotic 890A.sub.10
    Patent number: 4264736
    Abstract: The antibiotic MSD 890A.sub.10 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotic 890A.sub.10) is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: September 26, 1979
    Date of Patent: April 28, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Patrick J. Cassidy, Sheldon B. Zimmerman, Josefino B. Tunac, Sebastian Hernandez
  • Method of producing antibiotic 890A.sub.9
    Patent number: 4264735
    Abstract: The antibiotic MSD 890A.sub.9 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotic 890A.sub.9) is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: September 10, 1979
    Date of Patent: April 28, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Patrick J. Cassidy, Sheldon B. Zimmerman, Josefino B. Tunac, Sebastian Hernandez
  • Discovery of A73A, a new efrotomycin-like antibiotic in fermentation broth
    Patent number: 4262002
    Abstract: There is disclosed a new antibiotic agent, A73A, produced by Streptomyces viridifaciens MA-4864 (ATCC 31495) under suitable conditions. Said antibiotic shows antibacterial and growth-permittant activity.
    Type: Grant
    Filed: June 22, 1979
    Date of Patent: April 14, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Ray S. Dewey, James E. Flor, Sheldon B. Zimmerman, Patrick J. Cassidy, Satoshi Omura, Ruiko Oiwa
  • Process for producing antibiotic A21A
    Patent number: 4175007
    Abstract: Antibiotic A21A is produced by cultivating Stneptomyces filipinesis under aerobic conditions.
    Type: Grant
    Filed: November 21, 1977
    Date of Patent: November 20, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Sheldon B. Zimmerman, John H. Chalmers, Jr.
  • Antibiotic A21A
    Patent number: 4071631
    Abstract: There is disclosed a new antibiotic A21A which is produced by cultivating the microorganism, Streptomyces filipinensis, in aqueous nutrient medium. The antibiotic has growth-improving activity.
    Type: Grant
    Filed: October 29, 1976
    Date of Patent: January 31, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Sheldon B. Zimmerman, John H. Chalmers, Jr.