Abstract: The present inventions provide covalently surface modified adeno-associated viruses can comprise gene of interest (GOIs) and advantageously can be targeted to certain cell and tissue types for preventative and therapeutic purposes. The present inventions further provide systems and methods for engineering adeno-associated virus (AAV) to create covalently surface modified adeno-associated viruses, and methods of purifying such covalently surface modified adeno-associated viruses. The inventions further include covalently surface modified adeno-associated viruses and preparations and products comprising such covalently surface modified adeno-associated viruses.

Abstract: The inventions provide methods of purifying full adeno-associated virus (AAV) capsids, wherein the method comprises the steps of (a) subjecting a sample comprising AAV capsids in buffer to anion exchange chromatography (AEX) to separate full AAV capsids from capsids that are not full (that is, partially-filled AAV capsids, nearly empty AAV capsids and empty AAV capsids) and form a first pool (“first AEX pass”), wherein the first pool is enriched in the ratio of full capsids to capsids that are not full; and (b) subjecting the first pool to anion exchange chromatography to form a second pool (“second AEX pass”), wherein the second pool is further enriched in the ratio of full capsids to capsids that are not full (that is, partially-filled AAV capsids, nearly empty AAV capsids and empty AAV capsids), wherein the enrichment in full capsids can be least 3 fold. Third, fourth and more AEX passes also can be undertaken.

Abstract: The anesthesia systems have an integrated, extendable clinical center and clinician/anesthesia office that accommodates for a physical separation of clinical and clerical functions. The anesthesia system includes an alarm reversion system which enables a predefined alarm limit to be set and then to be automatically reverted back to an alarm limit existing just before the predefined alarm limit was set.

Abstract: The anesthesia systems have an integrated, extendable clinical center and clinician/anesthesia office that accommodates for a physical separation of clinical and clerical functions. The anesthesia system includes an alarm reversion system which enables a predefined alarm limit to be set and then to be automatically reverted back to an alarm limit existing just before the predefined alarm limit was set.

Abstract: The specification describes anesthesia systems with an integrated, extendable clinical center and clinician/anesthesia office that accommodates for physical separation of clinical and clerical functions. The disclosed anesthesia systems allow for a portion of the system to be brought closer to the patient such that clinical controls can be accessed while tending to the patient airway, without compromising office space available to the clinician or crowding the patient area.

Abstract: An ergonomically designed food slicing machine including a rotatable blade for slicing bulk food product, a motor operably connected to the rotating blade, and a base portion located below the rotatable blade which defines a food slice receiving area. The machine may be provided with a sliced food receptacle operably connected to a scale, a visible indicia correlating to the distance between the gauge plate and rotatable blade, a blade sharpening assembly, a sled for securing the food product and an operator adjusted optimum stroke setting system for automatic operation of the slicing machine.

Abstract: An ergonomically designed food slicing machine including a rotatable blade for slicing bulk food product, a motor operably connected to the rotating blade, and a base portion located below the rotatable blade which defines a food slice receiving area. The machine may be provided with a sliced food receptacle operably connected to a scale, a visible indicia correlating to the distance between the gauge plate and rotatable blade, a blade sharpening assembly, a sled for securing the food product and an operator adjusted optimum stroke setting system for automatic operation of the slicing machine.

Abstract: An ergonomically designed food slicing machine including a rotatable blade (800, 2800) for slicing bulk food product, a motor (1400, 3400) operably connected to the rotating blade (800, 2800), and a base (100) portion located below the rotatable blade (800, 2800) which defines a food slice receiving area. The machine may be provided with a sliced food receptable operably connected to a scale (3900), a visible indicia (3502) correlating to the distance between the gauge plate (2500) and rotatable blade (2800), a blade sharpening assembly (900, 2900), a sled (200) for securing the food product and an operator adjusted optimum stroke setting system for automatic operation of the slicing machine.

Abstract: A shutter section includes a stack of circular plates independently rotatable in a nest formed as a laminar formation of rings. The plates have central openings defining a light path. Four central plates in the stack are shutter guide plates with radial guide slots slideably holding shutter blades. Two outer pairs of plates are shutter drive plates connected by cams to the shutter blades. Simultaneous rotation of a shutter guide plate and associated shutter drive plate causes rotation of an associated shutter blade around the light path. Rotation of a shutter drive plate while the associated shutter guide plate is stationary causes the cam to move the associated shutter blade radially. The nest is enclosed by end plates. A motor section has motors driving pinions to rotate the circular plates. The circular plates, rings pinions and shutter blades are made of sheet metal. Shutters may be provided as interleaved pairs each driven by a pair of rotatable drive plates.

Abstract: A shutter section includes a stack of circular plates independently rotatable in a nest formed as a laminar formation of rings. The plates have central openings defining a light path. Four central plates in the stack are shutter guide plates with radial guide slots slideably holding shutter blades. Two outer pairs of plates are shutter drive plates connected by cams to the shutter blades. Simultaneous rotation of a shutter guide plate and associated shutter drive plate causes rotation of an associated shutter blade around the light path. Rotation of a shutter drive plate while the associated shutter guide plate is stationary causes the cam to move the associated shutter blade radially. The nest is enclosed by end plates. A motor section has motors driving pinions to rotate the circular plates. The circular plates, rings pinions and shutter blades are made of sheet metal.

Abstract: A shutter section includes a stack of circular plates independently rotatable in a nest formed as a laminar formation of rings. The plates have central openings defining a light path. Four central plates in the stack are shutter guide plates with radial guide slots slideably holding shutter blades. Two outer pairs of plates are shutter drive plates connected by cams to the shutter blades. Simultaneous rotation of a shutter guide plate and associated shutter drive plate causes rotation of an associated shutter blade around the light path. Rotation of a shutter drive plate while the associated shutter guide plate is stationary causes the cam to move the associated shutter blade radially. The nest is enclosed by end plates. A motor section has motors driving pinions to rotate the circular plates. The circular plates, rings pinions and shutter blades are made of sheet metal. Shutters may be provided as interleaved pairs each driven by a pair of rotatable drive plates.

Abstract: A shutter section includes a stack of circular plates independently rotatable in a nest formed as a laminar formation of rings. The plates have central openings defining a light path. Four central plates in the stack are shutter guide plates with radial guide slots slideably holding shutter blades. Two outer pairs of plates are shutter drive plates connected by cams to the shutter blades. Simultaneous rotation of a shutter guide plate and associated shutter drive plate causes rotation of an associated shutter blade around the light path. Rotation of a shutter drive plate while the associated shutter guide plate is stationary causes the cam to move the associated shutter blade radially. The nest is enclosed by end plates. A motor section has motors driving pinions to rotate the circular plates. The circular plates, rings pinions and shutter blades are made of sheet metal.

Abstract: A protractor comprising a frame and a lever arm coupled thereto. The frame includes a first substantially straight edge and an elongate track adjacent to the first edge. The lever arm includes a second substantially straight edge and a channel which mateably engages the track of the frame. The channel/track combination couples the lever arm to the frame and permits the lever arm to rotate about an axis substantially orthogonal to the first and second edges. The first and second edges intersect at a point allowing a user to describe an angle between the two edges.

Abstract: Associative retrieval of data via the technique of superimposed code words is accomplished by circuitry which automatically generates the codes, and which searches through stored code words to find the ones that match a given query code. Code generation is performed using pseudo-random techniques that are reproducible, obviating the need for a pre-prepared code dictionary. Identification of the codes that meet a match requirement is accomplished by logically AND'ing selected bits from the stored codes, said selection being determined by the query code.

Abstract: The random cell scintillations which have been observed in animated dithered displays are substantially eliminated by establishing a hysteresis band about the dither threshold value assigned to each display cell. The hysteresis band is delimited by upper and lower dither threshold values. Determination of whether the intensity of each picture element of the image to be displayed is to be compared to the upper or the lower threshold value assigned to the corresponding display cell is made based on the current state of the cell.