Patents by Inventor Sheldon S. Lin
Sheldon S. Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220088271Abstract: The present invention is a method for producing allograft tissue by applying an antimicrobial solution to allograft tissue. The antimicrobial solution exhibits antimicrobial activity to make allograft resistant to microbial organisms, such as a bacterium.Type: ApplicationFiled: December 2, 2021Publication date: March 24, 2022Applicant: Rutgers, The State University of New JerseyInventors: Sheldon S. Lin, Joseph Benevenia, Michael J. Vives, Pradeep Kumar, David Alland, James Patrick O'Connor
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Patent number: 11224678Abstract: The present invention is a method for producing allograft tissue by applying an antimicrobial solution to allograft tissue. The antimicrobial solution exhibits antimicrobial activity to make allograft resistant to microbial organisms, such as bacterium.Type: GrantFiled: February 6, 2017Date of Patent: January 18, 2022Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Joseph Benevenia, Sheldon S. Lin, Michael Vives
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Publication number: 20210251215Abstract: This disclosure provides systems and methods for storing and preserving an implantable device. The system comprises a first sealable container; a second sealable container housed within the first sealable container; and a storage solution comprising a zinc compound contained in the second sealable container. The storage solution exhibits antimicrobial activity of inhibiting or controlling growth of microbial organisms and is capable of maintaining the implantable device in a hydrated state.Type: ApplicationFiled: May 4, 2021Publication date: August 19, 2021Applicant: Rutgers, The State University of New JerseyInventors: Joseph Benevenia, Sheldon S. Lin, Michael J. Vives
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Publication number: 20180318344Abstract: A method for repairing an injury of cartilage in a patient by local administration of a zinc or manganese agent or use of an implantable device for delivery of an a zinc or manganese agent. Implantable devices containing a zinc or manganese agent and methods of making these implantable devices are also disclosed.Type: ApplicationFiled: April 2, 2018Publication date: November 8, 2018Inventors: Sheldon S. Lin, David N. Paglia, James P. O'Connor, Aaron Wey, Joseph Benevenia, Virak Tan
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Patent number: 9999636Abstract: Methods of promoting bone healing or regeneration by locally administering insulin mimetic agents to patients in need thereof and new uses of insulin-mimetic compounds for accelerating bone-healing processes are disclosed. Bone injury treatment and void filler devices, products and kit suitable for local administration of insulin-mimetic, agents or compositions thereof to patients in need of such treatment are also disclosed.Type: GrantFiled: January 29, 2016Date of Patent: June 19, 2018Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Sheldon S. Lin, David N. Paglia, James P. O'Connor, Joseph Benevenia, Aaron Wey, Sangeeta Subramanian, John Koerner, Paul Chirichella, Michael J. Vives
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Patent number: 9931348Abstract: A method for repairing an injury of cartilage in a patient by local administration of an organovanadium agent or use of an implantable device for delivery of an organovanadium agent. Implantable devices containing an organovanadium agent and methods of making these implantable devices are also disclosed.Type: GrantFiled: July 6, 2012Date of Patent: April 3, 2018Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Sheldon S. Lin, David N. Paglia, James P. O'Connor, Aaron Wey, Joseph Benevenia, Virak Tan
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Patent number: 9730946Abstract: This invention provides a method of promoting bone healing by locally administering a vanadium-based insulin mimetic agent to a patient in need thereof. The invention also provides a new use of insulin-mimetic vanadium compounds for manufacture of medicaments for accelerating bone-healing processes. In addition, the invention also encompasses a bone injury treatment kit suitable for localized administration of insulin-mimetic vanadium compounds or compositions thereof to a patient in need of such treatment.Type: GrantFiled: December 10, 2014Date of Patent: August 15, 2017Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Sheldon S. Lin, David N. Paglia, James P. O'Connor, Eric Breitbart, Joseph Benevenia
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Publication number: 20170224871Abstract: The present invention is a method for producing allograft tissue by applying an antimicrobial solution to allograft tissue. The antimicrobial solution exhibits antimicrobial activity to make allograft resistant to microbial organisms, such as bacterium.Type: ApplicationFiled: February 6, 2017Publication date: August 10, 2017Inventors: Joseph Benevenia, Sheldon S Lin, Michael Vives
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Publication number: 20170035803Abstract: Bone tissue materials comprising insulin-mimetic agents, such as suitable zinc, vanadium, tungsten, molybdenum, niobium, selenium, and manganese compounds, for facilitating spinal fusion of vertebrae M spinal fusion surgical procedures, and methods thereof. Additionally provided is a bone tissue kit for facilitating fusion of vertebrae in a spinal fusion surgical procedure including a composition formulated for facile application in a spinal fusion procedure comprising an insulin-mimetic agent and a pharmaceutically acceptable carrier. Yet further provided is an implantable device for enhancing spinal fusion including a prosthetic implant configured to stabilize and promote the fusion of two adjacent vertebrae, wherein the bone tissue contacting surfaces of the prosthetic implant are coated with a composition comprising an insulin-mimetic agent.Type: ApplicationFiled: October 19, 2016Publication date: February 9, 2017Inventors: Sheldon S. Lin, John Koerner, Michael J. Vives, Joseph Benevenia, Eric Breitbart
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Publication number: 20160151416Abstract: Methods of promoting bone healing or regeneration by locally administering insulin mimetic agents to patients in need thereof and new uses of insulin-mimetic compounds for accelerating bone-healing processes are disclosed. Bone injury treatment and void filler devices, products and kit suitable for local administration of insulin-mimetic, agents or compositions thereof to patients in need of such treatment are also disclosed.Type: ApplicationFiled: January 29, 2016Publication date: June 2, 2016Applicants: Rutgers, The State University of New Jersey, Rutgers, The State University of New JerseyInventors: Sheldon S. Lin, David N. Paglia, James P. O'Connor, Joseph Benevenia, Aaron Wey, Sangeeta Subramanian, John Koerner, Paul Chirichella, Michael J. Vives
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Patent number: 9265794Abstract: Methods of promoting bone healing or regeneration by locally administering insulin mimetic agents to patients in need thereof and new uses of insulin-mimetic compounds for accelerating bone-healing processes are disclosed. Bone injury treatment and void filler devices, products and kit suitable for local administration of insulin-mimetic agents or compositions thereof to patients in need of such treatment are also disclosed.Type: GrantFiled: August 26, 2014Date of Patent: February 23, 2016Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Sheldon S. Lin, David N. Paglia, James P. O'Connor, Joseph Benevenia, Aaron Wey, Sangeeta Subramanian, John D. Koerner, Paul Chirichella, Michael J. Vives
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Publication number: 20150314047Abstract: The present invention discloses boron composite surface coatings, application of these coatings onto implantable devices, and use of the implantable devices for accelerating osseous healing. The implantable devices have wide applications, including but not limited to treating bone fracture, bone trauma, arthrodesis, and other bone deficit conditions, as well as bone injuries incurred in military and sports activities.Type: ApplicationFiled: May 1, 2014Publication date: November 5, 2015Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Sheldon S. Lin, David N. Paglia, James P. O'Connor, Eric Breitbart, Joseph Benevenia
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Patent number: 9144633Abstract: The present invention discloses vanadium-based insulin-mimetic agent composite coatings, application of these coatings onto implantable devices, and use of the implantable devices for accelerating osseous healing. The invention also encompasses methods of manufacturing implantable devices coated with vanadium-based insulin-mimetic agent composite coatings and the implantable devices so manufactured. The implantable devices have wide applications, including but not limited to treating bone fracture, bone trauma, arthrodesis, and other bone deficit conditions, as well as bone injuries incurred in military and sports activities.Type: GrantFiled: December 9, 2011Date of Patent: September 29, 2015Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Sheldon S. Lin, David N. Paglia, James Patrick O'Connor, Eric Breitbart, Joseph Benevenia
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Publication number: 20150099804Abstract: This invention provides a method of promoting bone healing by locally administering a vanadium-based insulin mimetic agent to a patient in need thereof. The invention also provides a new use of insulin-mimetic vanadium compounds for manufacture of medicaments for accelerating bone-healing processes. In addition, the invention also encompasses a bone injury treatment kit suitable for localized administration of insulin-mimetic vanadium compounds or compositions thereof to a patient in need of such treatment.Type: ApplicationFiled: December 10, 2014Publication date: April 9, 2015Inventors: Sheldon S. Lin, David N. Paglia, James P. O'Connor, Eric Breitbart, Joseph Benevenia
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Publication number: 20150030653Abstract: A method for repairing an injury of cartilage in a patient by local administration of an organovanadium agent or use of an implantable device for delivery of an organovanadium agent. Implantable devices containing an organovanadium agent and methods of making these implantable devices are also disclosed.Type: ApplicationFiled: July 6, 2012Publication date: January 29, 2015Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Sheldon S. Lin, David N. Paglia, James P. O'Connor, Aaron Wey, Joseph Benevenia, Virak Tan
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Publication number: 20150010499Abstract: Methods of promoting bone healing or regeneration by locally administering insulin mimetic agents to patients in need thereof and new uses of insulin-mimetic compounds for accelerating bone-healing processes are disclosed. Bone injury treatment and void filler devices, products and kit suitable for local administration of insulin-mimetic agents or compositions thereof to patients in need of such treatment are also disclosed.Type: ApplicationFiled: August 26, 2014Publication date: January 8, 2015Inventors: Sheldon S. Lin, David N. Paglia, James P. O'Connor, Joseph Benevenia, Aaron Wey, Sangeeta Subramanian, John D. Koerner
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Publication number: 20150004249Abstract: Bone tissue materials comprising insulin-mimetic agents, such as suitable zinc, vanadium, tungsten, molybdenum, niobium, selenium, and manganese compounds, for facilitating spinal fusion of vertebrae in spinal fusion surgical procedures, and methods thereof. Additionally provided is a bone tissue kit for facilitating fusion of vertebrae in a spinal fusion surgical procedure including a composition formulated for facile application in a spinal fusion procedure comprising an insulin-mimetic agent and a pharmaceutically acceptable carrier. Yet further provided is an implantable device for enhancing spinal fusion including a prosthetic implant configured to stabilize and promote the fusion of two adjacent vertebrae, wherein the bone tissue contacting surfaces of the prosthetic implant are coated with a composition comprising an insulin-mimetic agent.Type: ApplicationFiled: September 18, 2014Publication date: January 1, 2015Inventors: Sheldon S. Lin, John Koerner, Michael J. Vives, Joseph Benevenia, Eric Breitbart
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Publication number: 20140322292Abstract: Methods of promoting bone healing or regeneration by locally administering insulin mimetic agents to patients in need thereof and new uses of insulin-mimetic compounds for accelerating bone-healing processes are disclosed. Bone injury treatment and void filler devices, products and kit suitable for local administration of insulin-mimetic agents or compositions thereof to patients in need of such treatment are also disclosed.Type: ApplicationFiled: November 29, 2012Publication date: October 30, 2014Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Sheldon S. Lin, David N. Paglia, James P. O'Connor, Joseph Benevenia, Aaron Wey, Sangeeta Subramanian, John D. Koerner
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Publication number: 20140044768Abstract: The present invention discloses vanadium-based insulin-mimetic agent composite coatings, application of these coatings onto implantable devices, and use of the implantable devices for accelerating osseous healing. The invention also encompasses methods of manufacturing implantable devices coated with vanadium-based insulin-mimetic agent composite coatings and the implantable devices so manufactured. The implantable devices have wide applications, including but not limited to treating bone fracture, bone trauma, arthrodesis, and other bone deficit conditions, as well as bone injuries incurred in military and sports activities.Type: ApplicationFiled: December 9, 2011Publication date: February 13, 2014Applicant: University of Medicine and Dentistry of New JerseyInventors: Sheldon S. Lin, David N. Paglia, Eric Breitbart, Joseph Benevenia
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Patent number: 5281419Abstract: An antibiotic impregnated fracture fixation device and antibiotic impregnated drug delivery polymer are provided. In a preferred embodiment, a homogenous mixture of thermally melted poly(lactic) acid and at least one antibiotic and/or antibacterial agent are employed.Type: GrantFiled: September 28, 1992Date of Patent: January 25, 1994Assignee: Thomas Jefferson UniversityInventors: Rocky S. Tuan, Sheldon S. Lin