Patents by Inventor Shelley P.M. Fussey

Shelley P.M. Fussey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for isolating exosomes
    Patent number: 9835626
    Abstract: Disclosed are surprising new methods and compositions for isolating extracellular microvesicles such as exosomes, particularly disease-related and phosphatidylserine (PS)-positive extracellular microvesicles as exemplified by tumor- and viral-derived exosomes. The methods of the invention are rapid, efficient, cost-effective and, importantly, are suitable for use with large volumes of biological fluids and produce antigenically intact extracellular microvesicles and exosomes. The methods and compositions are based on the surprising use of acetate buffers to isolate large quantities of extracellular microvesicles, particularly tumor-derived exosomes, from solution, without damaging their morphological or functional properties or antigenicity.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: December 5, 2017
    Assignees: Board of Regents, The University of Texas System, Peregrine Pharmaceuticals, Inc.
    Inventors: Alan J. Schroit, Philip E. Thorpe, Shelley P. M. Fussey
  • Methods and Compositions for Isolating Exosomes
    Publication number: 20150241431
    Abstract: Disclosed are surprising new methods and compositions for isolating extracellular microvesicles such as exosomes, particularly disease-related and phosphatidylserine (PS)-positive extracellular microvesicles as exemplified by tumor- and viral-derived exosomes. The methods of the invention are rapid, efficient, cost-effective and, importantly, are suitable for use with large volumes of biological fluids and produce antigenically intact extracellular microvesicles and exosomes. The methods and compositions are based on the surprising use of acetate buffers to isolate large quantities of extracellular microvesicles, particularly tumor-derived exosomes, from solution, without damaging their morphological or functional properties or antigenicity.
    Type: Application
    Filed: February 27, 2015
    Publication date: August 27, 2015
    Inventors: Alan J. Schroit, Philip E. Thorpe, Shelley P.M. Fussey