Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: An article of manufacture comprises: a hollow prism of elastomeric material such as silicone having first and second ends; and a permanent magnet prism at the first end of the elastomeric material prism. The second end of the elastomeric material prism is open. A cosmetic brush handle is releasably gripped by the elastomeric material at its open end. The article of manufacture is desirably in combination with a number of cosmetic brushes and a horizontal surface at least partly of magnetic material large enough to accommodate the cosmetic brushes with the permanent magnets engaging the horizontal surface so that the brushes are substantially vertical and their bristles don't touch any surface.

Abstract: An article of manufacture comprises: a hollow prism of elastomeric material such as silicone having first and second ends; and a permanent magnet prism at the first end of the elastomeric material prism. The second end of the elastomeric material prism is open. A cosmetic brush handle is releasably gripped by the elastomeric material at its open end. The article of manufacture is desirably in combination with a number of cosmetic brushes and a horizontal surface at least partly of magnetic material large enough to accommodate the cosmetic brushes with the permanent magnets engaging the horizontal surface so that the brushes are substantially vertical and their bristles don't touch any surface.

Abstract: A makeup sponge has first and second polyurethane portions each defining a three dimensional body. The portions are of easily differentiated colors and are attached along a line of attachment by polyurethane adhesive. The density of the first portion is typically about 80 kg/m3˜130 kg/m3 and the pore size about 30-60 PPI (pores per linear inch) to achieve a light to medium makeup coverage. The density of the second portion is typically about 150 kg/m3˜200 kg/m3 with a pore size of about 100-150 PPI to achieve a medium to heavy expert makeup coverage. The sponge may have a pointed tip and flat base opposite the tip, and is utilizable to apply all types of makeup including foundation, concealer, and contour makeups.

Abstract: An article of manufacture comprises: a hollow prism of elastomeric material such as silicone having first and second ends; and a permanent magnet prism at the first end of the elastomeric material prism. The second end of the elastomeric material prism is open. A cosmetic brush handle is releasably gripped by the elastomeric material at its open end. The article of manufacture is desirably in combination with a number of cosmetic brushes and a horizontal surface at least partly of magnetic material large enough to accommodate the cosmetic brushes with the permanent magnets engaging the horizontal surface so that the brushes are substantially vertical and their bristles don't touch any surface.

Abstract: A hair treatment material applicator comprises a lid, a base, a hinge connecting the lid and base to allow pivotal movement of the lid and base with respect to each other from an open position to a closed position; and a bail pivotally mounted to the lid for pivotal movement from a use position above the lid to a latch position below the base holding the lid and base in the closed position. A compressible material, such as dense foam, is positioned in one of the lid and base; and a hair treatment material (such as highlighter, dye, bleach, protein treatment, etc.) is positioned in the other of the lid and base. The foam and material are positioned to allow strands of human hair to pass between them for uniform application of material to the strands. The hinge is an over-molded rubber hinge biasing the lid and base open.