Abstract: The present invention discloses an optical sensor for measuring blood gas, used to measure gas concentration in a liquid, comprising: an indicator solution; a first conduit for filling with the indicator solution wherein the first conduit passes through the liquid and the gas in the liquid can diffuse into the first conduit to react with the indicator solution so as to change the color of the indicator solution; a second conduit for receiving the reacted indicator solution in the first conduit; and a light emitter and a photodetector provided in opposition to each other at the two sides of the second conduit wherein the light emitter emits light towards the second conduit and the photodetector receives the light passing through the second conduit and the reacted indicator solution and thereby outputs a sensing signal depending on the received light intensity.

Abstract: A solid-state urea biosensor may comprise a substrate, an electrically conductive layer, a PH sensing film, an ammonium ion selecting film and a ferment film. The electrically conductive layer covers the substrate. The PH sensing film has a PH value measuring zone, partially covering the electrically conductive layer, for measuring the PH value of a solution to be tested. The ammonium ion selecting film has an ammonium ion measuring zone for measuring the ammonium ion concentration. The ammonium ion selecting film partially covers the PH sensing film and exposes the PH value measuring zone. The ferment film is used for measuring the urea concentration in the solution, wherein the ferment film partially covers the ammonium ion selecting film and exposes the ammonium ion measuring zone.

Abstract: A moisture-sensitive element with an interdigital capacitor (IDC) and fabrication thereof are disclosed, wherein the moisture-sensitive element with the interdigital capacitor investigates a moisture sensor for the determination of human skin moisture based on the interdigital capacitor. The moisture-sensitive element with an interdigital capacitor comprises a printed circuit board (PCB), an interdigital capacitor formed on the printed circuit board, and a moisture sensing layer formed on the interdigital capacitor.

Abstract: A method for fabricating an array pH sensor and a readout circuit device of such array pH sensor are implemented by utilizing an extended ion sensitive field effect transistor to construct the array pH sensor and related readout circuit. The structure of the array sensor having this extended ion sensitive field effect transistor comprises a tin dioxide/metal/silicon dioxide multi-layer structure sensor and a tin dioxide/indium tin oxide/glass multi-layer structure sensor and has excellent properties. Furthermore, the readout circuit and the sensor utilize two signal generators for controlling and reading signals. In particular, the sensor can be effective for increasing the accuracy of measurement and reducing the interference of noise.

Abstract: An optical gas concentration sensor and method for measuring blood gas based on the light adsorption sensing technique are disclosed. The optical gas concentration sensor comprises a light source, a photo detector, and a gas filtering membrane for separating the indicator and a liquid. A gas in the liquid diffuses to the indicator through the gas filtering membrane so as to change the color of the indicator due to the chemical reaction occurred between the indicator and the gas. Then, the photo detector receives the light passing though the reacted indicator from the light source. The gas concentration is determined based on pH-sensitive absorbance spectrum of the indicator.

Abstract: The invention provides a method of fabrication of a solid-state urea biosensor and its data acquisition system. The biosensor includes a substrate, and three individual sensing areas separated by an insulating layer on the substrate. Each individual sensing area contains a conductive layer on the substrate, and a pH sensitive membrane is deposited thereon. An enzyme layer is deposited on one of the pH sensitive membranes to form a working electrode. The other two sensing areas are a quasi-reference electrode and a contrast electrode, respectively. The sensing signals are transferred to an instrumentation amplifier by conductive wires. The sensing signals are then transferred to a low-pass filter to reduce the high frequency noise. A data acquisition card is employed to transfer the sensing signals to a computer. The sensing signals are analyzed by the program of the data acquisition system. The data are then displayed on the display panel.

Abstract: A multi-functional PH meter and the fabrication thereof are disclosed. The multi-functional pH meter immediately displays the measurement result on a liquid crystal display and saves in a compact flash card so as to provide portable functionality. In addition, the multi-functional pH meter has data communication functionality with a computer. Finally, the drift and hysteresis software calibration technique is applied. Thus, this method can increase ion detection accuracy and system reliability. The multi-functional pH meter includes a sensor unit, an analog signal processing unit, a microprocessor unit, the liquid crystal display unit, the compact flash card unit and a data transmission unit.

Abstract: A multi-functional PH meter and the fabrication thereof are disclosed. The multi-functional pH meter comprises a sensor unit, an analog signal processing unit, a microprocessor unit, a liquid crystal display unit, a compact flash card unit and a data transmission unit. The sensor unit includes an electrode, a substrate, an indium tin oxide film on the substrate, a sensing film on the indium tin oxide film and connecting to a conductive wire, a package material covering the sensing film, the indium tin oxide film and a portion of the substrate and exposing the sensing film via a sensing window. The analog signal processing unit processes analog signals from the sensing unit via the conductive wire. The microprocessor unit receives the signals from the analog signal processing unit and generates a pH value of a solution being detected. The liquid crystal display unit displays the pH value and the compact flash card unit saves the pH value.

Abstract: An ion solution concentration-detecting device includes a working electrode, a reference electrode and a replaceable link element. The reference electrode includes a polymeric membrane with ion material covering silver/silver chloride (Ag/AgCl) electrode to provide a fixed and stable electrical potential. The working electrode usually is a contact-detecting electrode having a sensing membrane. The sensing membrane may be a metal oxide or a polymer with ion material for measuring different ion solution effectively. For the better sensitivity to the different ion solution, the working electrode bond with the replaceable link element is replaceable. The working electrode being a contact-detecting electrode can be replaced by another contact-detecting electrode with different sensing membrane.

Abstract: A wireless pH measurement system is disclosed, the wireless pH measurement system includes a portable module and a receiver end. The portable module comprises a signal detecting and processing portion and a wireless transmission portion. The signal detecting and processing portion comprises a sensor unit for detecting a pH signal, amplifying, filtering noise, analog/digital conversion and numerical processing to generate a pH measurement signal. The wireless transmission portion receives the pH measurement signal via a transmission interface and transmits by a Bluetooth module. The receiver end includes a Bluetooth receiver for receiving the pH measurement signal. The receiver end processes the pH measurement signal by programs, displays, analyzes and stores the pH measurement signal and transmits warning signal when an abnormal pH measurement signal is received.

Abstract: An amperometric sensor for uric acid and a manufacturing method thereof are disclosed, in which polyacrylamide is used to fix catalase, uricase and ferrocenecarboxylic acid on a working electrode. In determining concentration of uric acid, hydrogen peroxide is produced when enzyme and uric acid react with each other and then a reduction current generated from enzyme on the electrode with an external voltage 200 mV applied is detected. In determining concentration of uric acid, a concentration range of 2.5-20 mg/dl is achieved and sensibility of the sensor in a linear portion is 5.17 uAcm?2(mg/dl)?1. In addition, reaction time required for the reaction between enzyme and uric acid is 5.17 uAcm?2(mg/dl)?1.

Abstract: This invention provides a pCO2 sensor, and more particularly, a potentiometric pCO2 sensor. The potentiometric pCO2 sensor has a substrate, a solid ion-sensing layer on the substrate, a solid electrolyte layer on the solid ion-sensing layer, and a gas-permeable layer on the solid electrolyte layer. In addition, the gas-permeable layer allows air molecules to diffuse through, the solid electrolyte layer change the pH value thereof according to the CO2 concentration in the diffusing air molecules, and the solid ion-sensing layer senses the pH change of the solid electrolyte layer to generate a sensing signal. By doing so, the quantity of the CO2 dissolved in the liquid can be measured.

Abstract: In this invention, a separative structure of the ion-selecting electrode is applied to fabricate the dual type potentiometric biosensor for creatinine detection. According to the fabrication process, the creatinine enzyme is immobilized onto a conductive layer of a substrate of pH sensing membrane and ammonium ion-selecting membrane. The conductive layer provides with a sensing region and a non-sensing region. A conductive line is extended from the conductive layer for using as an external electrical contact point. The dual type potentiometric creatinine biosensor was fabricated by using the enzyme immobilization method onto the surface of the selecting membrane of sensing membrane of pH sensing electrode and creatinine sensor.

Abstract: A method of fabricating an electrode assembly of a sensor is described. The sensor has a field effect transistor. The electrode assembly is separated from the field effect transistor by only a conductive line. The sensor is functioned to detect different glucose concentrations. A solid layer of tin oxide is deposited on a substrate board. A ?-D-glucose oxidase and polyvinylalchol bearing styrylpyridinium groups are placed in 100 ?l of sulfuric acid, to form an enzyme mixture. The enzyme mixture is dropped on the solid layer of tin oxide. The enzyme mixture is dried. The enzyme mixture is exposed to a UV ray. The enzyme mixture is dried and stabilized. The enzyme mixture is immersed in a sulfuric buffer.

Abstract: A potassium/sodium ion sensing device applying an extended-gate field effect transistor, which using an extended-gate ion sensitive field effect transistor (EGFET) as base to fabricate a potassium/sodium ion sensing device, using the extended gate of the extended-gate ion sensitive field effect transistor as a signal intercept electrode, and immobilizing the hydro-aliphatic urethane diacrylate (EB2001) intermixed with electronegative additive, potassium ionophore, sodium ionophore, and the like, to fabricate a potassium/sodium ion sensing electrode. The present invention utilizes the photocurability and good hydrophilicity of the hydro-aliphatic urethane diacrylate (EB2001), and fixes potassium/sodium ionophore, can obtain a non-wave filter, single-layer, stable signal potassium and sodium ion sensor.

Abstract: In this invention, an extended gate FET with a tin dioxide membrane is applied to fabricate a berberine sensor. There are two methods for fabricating the berberine sensor. First, it is mixed by the macromolecule polymer and electrocatalytic activities. The membrane is adsorbed on the SnO2/ITO glass and the berberine sensor is completed. Second, a polymer is used to immobilize enzyme on the substrate and detect the berberine. In this invention, the extended gate field effect transistor of the SnO2/ITO glass is applied to fabricate a durable berberine detection electrode. One of the berberine sensors that is macromolecule polymer, the optimal measurement environment is in distilled water and the best response curve can be realized, the detection rang is from 1×10?3M to 5×10?7M and the linear range is about 121.47 mV/pC. The berberine sensor based on the enzyme that optimal measurement environment is in 0.1M phosphate buffer solution at pH7.4 and better response curves can be obtained.

Abstract: The present discloses an ion sensor and its readout circuit. The sensor includes potentiometric, amperometric ion sensors or dual mode electrochemical sensor. The dual mode electrochemical sensors can be measured by the same measurement circuit system. The dual mode sensors are extended gate ion sensitive field effect transistors and amperometric biosensors. The measurement circuit system is adaptable to the different mode sensors.

Abstract: A method for fabricating an array pH sensor and a readout circuit device of such array pH sensor are implemented by utilizing an extended ion sensitive field effect transistor to construct the array pH sensor and related readout circuit. The structure of the array sensor having this extended ion sensitive field effect transistor comprises a tin dioxide/metal/silicon dioxide multi-layer structure sensor and a tin dioxide/indium tin oxide/glass multi-layer structure sensor and has excellent properties. Furthermore, the readout circuit and the sensor utilize two signal generators for controlling and reading signals. In particular, the sensor can be effective for increasing the accuracy of measurement and reducing the interference of noise.

Abstract: The present invention is a sensor for detecting urea using a separating-style structure of ion-selective electrode, in which an ammonium ion-selective membrane is immobilized on a conductive layer on the surface of a substrate, said conductive layer has a sensing region and a non-sensing region after packaged, and a conductive line is used to retrieve a sensing signal from said conductive layer. In the end, employing the enzyme immobilization method to immobilize a urea enzyme onto ammonium ion-selective membrane, thus the fabrication of a potentiometric urea sensor is completed.

Abstract: In this present invention it was fabricated to be relates to manufacturing a ceramic interface electrochemical reference electrode for use together with biomedical sensors. Most potentiometric biomedical sensors must have the need to be connected to a reference electrode to offer the readout circuit a stable voltage in the different solutions when measuring for providing that can provide a standard comparing voltage to avoid measuring errors caused by an unstable environment. Usually, However, the presently available commercial reference electrode we used is too big in size and inconvenient to store. For this reason we develop the ceramic interface electrochemical reference electrode which can minimize volume and need not to be preserved in the saturated solution for biosensor. Therefore, the ceramic interface electrochemical reference electrode of the present invention does not need to be stored in solution and can be minimized for use in future sensors.