Abstract: The present invention discloses a five-axis vertical machining system with automatic loading and unloading, including a feeding mechanism, a loading mechanism, and a numerical control machine tool. The feeding mechanism is arranged in front of a ram assembly, and the feeding mechanism drives a raw material to move along an X axis and/or a Y axis of the numerical control machine tool; the loading mechanism is fixed on the ram assembly; and the loading mechanism moves along a Z axis of the numerical control machine tool to drive the raw material onto a cradle assembly of the numerical control machine tool. The present invention realizes an automatic loading and unloading function by setting a feeding mechanism capable of automatic feeding and a loading mechanism with automatic loading to cooperate with each other, thereby improving the working efficiency and saving manpower.

Abstract: Embodiments of this application disclose a communications method, apparatus, and system, and relate to the communications field, so that an access network device reserves a context of a V2X terminal, thereby ensuring that the V2X terminal implements PC5 interface communication. The method includes: A core network device obtains capability information indicating that the V2X terminal supports PC5 interface communication. The core network device maintains or skips releasing a signaling connection between the V2X terminal and the core network device based on the obtained capability information after completion of V2X terminal registration.

Abstract: An automatic loading and unloading processing system includes a material storage assembly to store workpieces; a positioning device on a worktable; and a transport mechanism to transport the workpiece from the material storage assembly to the positioning device and transport the processed workpiece into the material storage assembly. The material storage assembly includes a material tray; fixing bases; a motion mechanism; and holders on the fixing base for fixing the workpiece, and the motion mechanism controls the movement of the material tray. The transport mechanism includes an auxiliary loading and unloading system arranged at a worktable to grab the holders and move horizontally; and a main loading and unloading system arranged on a main spindle to grab the holders and move vertically.

Abstract: Disclosed is an antibody that specifically recognizes and binds to folate receptor ?, also referred to as anti-folate receptor a antibody or anti-FR? antibody. Also disclosed is an antibody-drug conjugate of the anti-FR? antibody. Disclosed are uses of the anti-FR? antibody and the antibody-drug conjugate in the treatment of diseases related to FR? expression.

Abstract: The present invention discloses use of an anti-PD-L1/CD47 bispecific antibody in the treatment of a disease. A treatment method comprises administering to a patient in need thereof an effective amount of an anti-PD-L1/CD47 bispecific antibody or an antigen-binding fragment.

Abstract: The present disclosure relates to wireless communication methods and apparatuses. In one example method, a first device determines a positioning manner based on a positioning requirement on a first terminal device and a second terminal device, where the positioning manner includes at least one of the following manners: performing positioning through a first interface between the first terminal device and a corresponding access network device, performing positioning through a second interface between the second terminal device and a corresponding access network device, or performing positioning through a third interface between the first terminal device and the second terminal device. The first device sends first information according to the positioning manner, where the first information is used to perform positioning in the positioning manner.

Abstract: A wireless communication method and an apparatus. The method includes receiving, by a first device, a first request message from a second device, where the first request message is associated with requesting relative location information between a first terminal device and a second terminal device, or the first request message is associated with requesting measurement information between the first terminal device and the second terminal device, where the measurement information is associated with determining the relative location information, and where the relative location information comprises at least one of relative positioning information, relative distance information, or relative angle information, and sending, by the first device, the relative location information or the measurement information to the second device in response to the first request message.

Abstract: Disclosed is an anti-B7-H3 antibody and application of an anti-B7-H3 antibody. The anti-B7-H3 antibody or an antigen-binding fragment can specifically bind to B7-H3. The anti-B7-H3 antibody or an antigen-binding fragment has high affinity and strong internalization capability, and can be used for the diagnosis and/or treatment of tumors (including cancers and benign tumors).

Abstract: An array of lenslets include a first surface with a plurality of individual cells defining one side of a respect lenslet, a second opposite surface with a set of grooves defining a second side of the array of lenslets. The array of lenslets is a circular arry having a plurality of concentric rings. Each ring includes a plurality of straight segments, and each segment includes lenslets arranged in a row. The lens is disposed over a carrier having an array of light emitting diodes (LEDS) disposed such that some of the LEDs are offset from a center of an associated cell, or a plurality associated with a shared cell and disposed at different positions along a groove direction.

Abstract: A drug conjugate, such as an antibody drug conjugate, and the use thereof, belonging to the field of biomedicine. In some embodiments, the drug conjugate is a compound of Formula I or a pharmaceutically acceptable salt or a solvate thereof, and can be used for treating cancers, autoimmune diseases, inflammatory diseases or infectious diseases.

Abstract: The present invention provides an antibody and a fusion protein for treating coronaviruses and use thereof. The 6-HB interference polypeptide in the fusion protein of the present invention and a part of an antibody or an antigen-binding fragment work synergistically to prevent fusion of SARS-COV or SARS-COV-2 virus particles with cells, and mediate phagocytosis and clearance of the virus particles by immune cells.

Abstract: Disclosed is a power conversion circuit for quick response and a switching power supply, wherein an error compensation signal is obtained according to a sampled signal representing an output feedback signal or an average current through the inductor. A PWM control signal is generated according to the error compensation signal, a ramp signal, and a proportional signal, and is used to control switching operations of a main power switch transistor, the proportional signal is proportional to an input voltage or/and an output voltage, thus the system can quickly respond to transient change of the input voltage or the output signal and provide stable output. Output voltage information or/and input voltage information can be fed back to a control loop, thus the system can quickly obtain a switching duty cycle which allows the system to operate in a state close to steady, and dynamic response speed of the system is fast.

Abstract: The present invention relates to the field of bio-pharmaceuticals and provides an anti-CLDN18.2 antibody. Related preparation methods and related uses are described. The antibody of the present invention or related an antigen-binding fragment can specifically bind to CLDN18.2 with a strong binding capacity. After humanization, the antibody or the antigen-binding fragment has a strong ADCC effect and CDC activity and has good pharmaceutical prospects.

Abstract: The present invention provides a bispecific antibody and use thereof, and the bispecific antibody or an antigen-binding fragment of the present invention can bind to two or more antigens or two or more epitopes of a same antigen. The antibody or the antigen-binding fragment of the present invention can be used to treat a variety of diseases, such as inflammatory diseases, autoimmune diseases, cancers or spinal cord injury, and can also be used for diagnosis and prognosis of related diseases.

Abstract: Disclosed are anti-PD-1 antibodies and use of an anti-PD-1 antibody in a combination therapy. Treatment methods are disclosed and include administering to a patient in need an effective amount of an anti-PD-1 antibody and a therapeutic agent. Methods for treating a tumor or cancer using anti-PD-1 antibody and a therapeutic agent are disclosed.

Abstract: The use of an anti-OX40 antibody or an antigen-binding fragment in the treatment of a tumor or cancer, is described. Also described is a treatment method of a tumor or cancer and includes administering to a patient in need an effective amount of an anti-OX40 antibody or an antigen-binding fragment. Kits including an anti-OX40 antibody or an antigen-binding fragment are also described.

Abstract: Disclosed are anti-CD20 antibody formulations and use of anti-CD20 antibodies for the treatment of CD20 positive diseases, such as methods of using anti-CD20 antibodies for treating CD20 positive diseases, such as neuromyelitis optica spectrum disorders (NMOSD), non-Hodgkin's lymphoma (NHL), multiple sclerosis (MS), immune thrombocytopenia (ITP), rheumatoid arthritis (RA), Wegener's granulomatosis (WG), microscopic polyangiitis (MPA), lupus nephritis, systemic lupus erythematosus and chronic lymphocytic leukemia (CLL).

Abstract: A lens plate has an array of lenslets. A first surface comprises a plurality of individual cells, each cell delimiting one side of a respective lenslet of the array. A second opposite surface comprises a set of grooves, each groove delimiting a second, opposite side, of a sub-array of the lenslets of the array of lenslets. The array of lenslets is a circular array comprising a plurality of concentric rings. Each ring comprises a plurality of straight segments, and each segment comprises multiple said lenslets arranged in a row. The lens plate design thus combines grooves on one side which cover multiple lenslets and a cellular lens structure on the opposite side.

Abstract: CD47 antibodies and use thereof are disclosed, particularly to monoclonal antibodies that recognize CD47, and more particularly to CD47 antibodies that do not cause significant levels of hemagglutination, red blood cell reduction and platelet reduction, and to a method for preparing these antibodies and use of these monoclonal antibodies in the manufacture of medicaments for treating cancer or infection.

Abstract: Disclosed are anti-PD-L1 antibodies and use of anti-PD-1 antibodies. The antibody or the antigen-binding fragment can specifically bind to PD-L1 and block the interaction between PD-1 and PD-L1. The antibody or the antigen-binding fragment can help the immune system to clear tumor cells, and can also be used for the diagnosis and prognosis of a tumor or a cancer.