Abstract: A silicon-and germanium-based molecular sieve has a framework chemical composition as represented by the formula “SiO2.1/nGeO2”. The silicon/germanium molar ratio is 0.1n30. The molecular sieve has a unique X-ray diffraction pattern. It can be used in adsorptive separation, ion exchange, and catalytic conversion of organic compounds.

Abstract: The present invention provides an experimental platform for simulating a coal rock disaster of a coal mine extraction, including a base device, a coal simulation device, an immediate roof simulation device, a hydraulic support and a removable impact device. The coal simulation device is fixedly disposed on the base device; the hydraulic support is fixed on the base device and is located at one side of the coal simulation device; the immediate roof simulation device is disposed above the coal simulation device and the hydraulic support; the removable impact device is disposed above the immediate roof simulation device; the immediate roof simulation device is a rectangular frame; the rectangular frame is configured to pave a bulk simulation material and an immediate roof simulation material sequentially from the bottom up; and the removable impact device can impact the immediate roof simulation material and the bulk simulation material.

Abstract: Provided are a grouting anchor bolt and a grouting anchor cable for supporting of large deformation and constant resistance and a quantitative roadway supporting method, wherein an anchor bolt comprises a casing, a hollow rod body, an anchor cylinder, a tray, a fastening nut and a clamping pin, a front end of the casing is sealed and a rear end of the casing is opened, a middle position of the casing is provided with a plurality of grouting holes, an inner diameter of the casing from the middle position of the casing to the rear end becomes small gradually, a side surface of a front end of the hollow rod body is sleeved with an anchor cylinder, the anchor cylinder is inserted into the casing and movably connected with the casing, the anchor cylinder is connected with the casing through the clamping pin, a rear end of the hollow rod body is sequentially assembled and connected with the tray and the fastening nut.

Abstract: Provided are a grouting anchor bolt and a grouting anchor cable for supporting of large deformation and constant resistance and a quantitative roadway supporting method, wherein an anchor bolt comprises a casing, a hollow rod body, an anchor cylinder, a tray, a fastening nut and a clamping pin, a front end of the casing is sealed and a rear end of the casing is opened, a middle position of the casing is provided with a plurality of grouting holes, an inner diameter of the casing from the middle position of the casing to the rear end becomes small gradually, a side surface of a front end of the hollow rod body is sleeved with an anchor cylinder, the anchor cylinder is inserted into the casing and movably connected with the casing, the anchor cylinder is connected with the casing through the clamping pin, a rear end of the hollow rod body is sequentially assembled and connected with the tray and the fastening nut.

Abstract: Disclosed are systems and methods for acquiring movement information of a high-level rock stratum (HLRS) in a coal mine stope. The system includes information acquisition, information acquisition transfer, information storage and rock stratum position-state information analysis modules that are sequentially connected wireles sly; the information acquisition module is disposed in a drill hole of the HLRS; the information acquisition transfer module is disposed below the information acquisition module; the information storage module is disposed in a working area of the stope; the rock stratum position-state information analysis module is disposed in a haulage roadway of the stope.

Abstract: The present invention provides an experimental platform for simulating a coal rock disaster of a coal mine extraction, including a base device, a coal simulation device, an immediate roof simulation device, a hydraulic support and a removable impact device. The coal simulation device is fixedly disposed on the base device; the hydraulic support is fixed on the base device and is located at one side of the coal simulation device; the immediate roof simulation device is disposed above the coal simulation device and the hydraulic support; the removable impact device is disposed above the immediate roof simulation device; the immediate roof simulation device is a rectangular frame; the rectangular frame is configured to pave a bulk simulation material and an immediate roof simulation material sequentially from the bottom up; and the removable impact device can impact the immediate roof simulation material and the bulk simulation material.

Abstract: A nucleic acid encoding a chimeric antigen receptor expressed at surface of a T lymphocyte, said chimeric antigen receptor comprises, connected in the order of, an extracellular binding domain, a transmembrane region, and an intracellular signaling domain, wherein the extracellular binding domain comprises a single chain antibody, scFv(GPC3), which specifically recognizes the C-terminal epitope of GPC3. A genetically modified T lymphocyte having a chimeric antigen receptor expressed at surface thereof, and the chimeric antigen receptor is expressed by the nucleic acid described above.

Abstract: A clock circuit includes a buffer module, N multiplexers, and N clock gating cells. The buffer module includes an input end and N output ends, and is configured to enhance a driving capability of a clock signal received by the input end, and output the clock signal from the N output ends, and the N output ends are connected to data ends of the N clock gating cells one to one. Output ends of the N first multiplexers are connected to enabling ends of the N clock gating cells one to one. Each clock gating cell outputs a clock signal from an output end according to a frequency division logic signal or a gating logic signal received by an enabling end from an output end of a corresponding multiplexer and the clock signal received by a data end from an output end of the buffer module.

Abstract: A clock circuit includes a buffer module, N multiplexers, and N clock gating cells. The buffer module includes an input end and N output ends, and is configured to enhance a driving capability of a clock signal received by the input end, and output the clock signal from the N output ends, and the N output ends are connected to data ends of the N clock gating cells one to one. Output ends of the N first multiplexers are connected to enabling ends of the N clock gating cells one to one. Each clock gating cell outputs a clock signal from an output end according to a frequency division logic signal or a gating logic signal received by an enabling end from an output end of a corresponding multiplexer and the clock signal received by a data end from an output end of the buffer module.

Abstract: A nucleic acid encoding a chimeric antigen receptor expressed at surface of a T lymphocyte, said chimeric antigen receptor comprises, connected in the order of, an extracellular binding domain, a transmembrane region, and an intracellular signaling domain, wherein the extracellular binding domain comprises a single chain antibody, scFv(GPC3), which specifically recognizes the C-terminal epitope of GPC3. A genetically modified T lymphocyte having a chimeric antigen receptor expressed at surface thereof, and the chimeric antigen receptor is expressed by the nucleic acid described above.

Abstract: The present invention provides an epidermal growth factor receptor variant-de4 EGFR protein. The variant lacks the fourth exon of the epidermal growth factor receptor, and promotes tumor cell invasion/metastasis. The present invention also provides an encoding gene for the variant and a method of producing the variant by means of recombination technology.

Abstract: Provided are a novel Epidermal growth factor receptor variant-EGFRvA protein, a polynucleotide encoding the EGFRvA protein and a method of preparing the EGFRvA protein via recombination technology. Also provided is a uses of the polynucleotide encoding the EGFRvA protein. The EGFRvA protein has a function of promoting tumor cell invasion or promoting tumor cell migration.

Abstract: Use of DKK-1 protein or the nucleic acid sequence in preparation of cancer diagnostic agents or kits, method to detect liver cancer with the monoclonal antibody thereof, the kit comprising anti-DKK-1 antibody or protein specific nucleic acid probes, together with a label, and method to detecting specific DKK-1 protein expression are disclosed.

Abstract: The present invention provides an epidermal growth factor receptor variant-de4 EGFR protein. The variant lacks the fourth exon of the epidermal growth factor receptor, and promotes tumor cell invasion/metastasis. The present invention also provides an encoding gene for the variant and a method of producing the variant by means of recombination technology.

Abstract: The invention provides specific binding proteins and the uses thereof. Particularly, the present invention provides a monoclonal antibody which can effectively bind to epidermal growth factor receptor variant type III (EGFRvIII) or can partially bind to the epidermal growth factor receptor (EGFR) over-expressed in cells, but not bind to EGFR normally-expressed in cells. Furthermore, the present invention said antibody has obvious therapeutic effect on a tumor cell line expressing the EGFRvIII. The invention also provides a method for preparing said monoclonal antibody and a pharmaceutical composition comprising said monoclonal antibody.

Abstract: The present invention discloses a method for preparing alginate nanocapsules, including the steps of: (a) forming a water-in-oil emulsion including an alginate in water, an oil, and at least one nonionic surfactant; and (b) separating the aqueous phase and oil phase to obtain the semisolid form alginate nanocapsules; and (c) by ionically crosslinking the alginate with calcium ions to obtain a colloidal form of calcium alginate nanocapsules for drug delivery.

Abstract: The invention provides specific binding proteins and the uses thereof. Particularly, the present invention provides a monoclonal antibody which can effectively bind to epidermal growth factor receptor variant type III (EGFRvIII) or can partially bind to the epidermal growth factor receptor (EGFR) over-expressed in cells, but not bind to EGFR normally-expressed in cells. Furthermore, the present invention said antibody has obvious therapeutic effect on a tumor cell line expressing the EGFRvIII. The invention also provides a method for preparing said monoclonal antibody and a pharmaceutical composition comprising said monoclonal antibody.

Abstract: Provided are a novel Epidermal growth factor receptor variant-EGFRvA protein, a polynucleotide encoding the EGFRvA protein and a method of preparing the EGFRvA protein via recombination technology. Also provided is a uses of the polynucleotide encoding the EGFRvA protein. The EGFRvA protein has a function of promoting tumor cell invasion or promoting tumor cell migration.

Abstract: Use of DKK-1 protein or the nucleic acid sequence in preparation of cancer diagnostic agents or kits, method to detect liver cancer with the monoclonal antibody thereof, the kit comprising anti-DKK-1 antibody or protein specific nucleic acid probes, together with a label, and method to detecting specific DKK-1 protein expression are disclosed.

Abstract: Use of DKK-1 protein or the nucleic acid sequence in preparation of cancer diagnostic agents or kits, method to detect liver cancer with the monoclonal antibody thereof, the kit comprising anti-DKK-1 antibody or protein specific nucleic acid probes, together with a label, and method to detecting specific DKK-1 protein expression are disclosed.