Patents by Inventor Sheng Niu

Sheng Niu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prodrug forms of ribonucleotide reductase inhibitors 3-AP and 3-AMP
    Patent number: 5767134
    Abstract: The present invention relates to novel prodrug forms of ribonucleoside diphosphate reductase inhibitors 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) 3-amino-4-methylpyridine-2-carboxaldehyde thiosemicarbazone (3-AMP) which have increased water solubility, bioavailablity and resistance to in vivo acetylation of their amino functions. Novel compounds according to the present invention relate to those of the formula: ##STR1## where R.sup.4 is H or CH.sub.3 andR.sup.5 is CHR, benzyl or ortho or para substituted benzyl;R is H, CH.sub.3, CH.sub.2 CH.sub.3, CH.sub.2 CH.sub.2 CH.sub.3 or ##STR2## R' is a free acid phosphate, phosphate salt or an --S--S--R" group; R" is CH.sub.2 CH.sub.2 NHR.sup.6, CH.sub.2 CH.sub.2 OH, CH.sub.2 COOR.sup.7, an ortho or para substituted alkylphenyl and ortho or para substituted nitro-phenyl;R.sup.6 is H, C.sub.1 -C.sub.4 acyl group, trifluoroacetyl, benzoyl or substituted benzoyl group, andR.sup.7 is H, C.sub.1 -C.sub.4 alkyl or a benzyl or substituted benzyl.
    Type: Grant
    Filed: May 15, 1997
    Date of Patent: June 16, 1998
    Assignee: Vion Pharmaceuticals, Inc.
    Inventors: Jun Li, Chuan-Sheng Niu, Xiuyan Li, Terrence W. Doyle, Shu-Hui Chen
  • Desk box fan
    Patent number: D686308
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: July 16, 2013
    Assignee: Gree Electric Appliances (Zhongshan) Small Home Appliances Manufacturing Ltd.
    Inventors: Luan Qin, Hongbing Wang, Sheng Niu, Xiao Wang, Jinfu Zhong, Jianfei Hou, Juan Xiao