Abstract: Aspects of the disclosure include a fabrication platform for supporting a bioprinted fiber structures during printing, patterning, and/or processing, comprising a frame with a plurality of posts for securing a cross-linkable fiber during printing thereof, and where a continuous length of the cross-linkable fiber is printed around a plurality of posts during the 3D bioprinting process. The fabrication platform enables the cross-linkable fiber to be suspended during one or more of printing, patterning, and/or processing. In this way, the bioprinted fiber structure comprises a uniform outer surface, and can be easily modified and/or further processed after printing and patterning are completed.

Abstract: Provided herein are synthetic living tissue structures comprising multiple layers of fibers deposited in solidified form from a 3D bioprinter, together with kits and methods of use related thereto. The fibers comprise a plurality of mammalian cells dispensed within a solidified biocompatible matrix. The structural integrity of the fiber is maintained upon and after deposition without any additional crosslinking. The fiber is continuously bioprinted through at least two layers of the structure. In one aspect, synthetic muscle tissue structures exhibit a readily assayable contractile functionality.

Abstract: Aspects of the disclosure include an implantable composition/medical device encapsulating insulin-producing cells for use in the treatment and management of diabetes, generally comprising a multilayer lattice structure fabricated from a continuously bioprinted cell-laden core/shell fiber, the lattice structure having a defined infill density and at least coating applied to the lattice post-printing, and preferably at least one conformal coating. In this way, multilayer lattice structures are provided with improved stability, retrievability, and functionality.

Abstract: A print head, system and method for producing hollow fiber structures, for example three-dimensional biological structures comprising living cells, includes a dispensing channel, a core channel converging with the proximal end of the dispensing channel, a first shell channel converging with the core channel and the dispensing channel at a focusing intersection or chamber, and a sheath flow channel converging with the dispensing channel at a sheath flow intersection or chamber located between the focusing intersection or chamber and the distal end of the dispensing channel. The diameter of the dispensing channel increases from a first diameter to a second diameter at the sheath flow intersection or chamber, and the core channel has a third diameter less than the first and second diameters. The sheath flow channel includes sheath flow sub-channels and the focusing chamber has a conical frustum shape.

Abstract: Aspects of the invention include systems and methods for producing selectively permeable cell laden solid core fiber structures, and for producing three-dimensional (3D) biological structures for digital files. In embodiments, the printed fibers comprise living cells embedded in at least one annulus layer or the printed fibers comprise a solid core of at least one biological material. The tissue fiber can be used in tissue engineering as synthetic tissue structures.

Abstract: A print head, system and method for producing hollow fiber structures, for example three-dimensional biological structures comprising living cells, includes a dispensing channel, a core channel converging with the proximal end of the dispensing channel, a first shell channel converging with the core channel and the dispensing channel at a focusing intersection or chamber, and a sheath flow channel converging with the dispensing channel at a sheath flow intersection or chamber located between the focusing intersection or chamber and the distal end of the dispensing channel. The diameter of the dispensing channel increases from a first diameter to a second diameter at the sheath flow intersection or chamber, and the core channel has a third diameter less than the first and second diameters. The sheath flow channel includes sheath flow sub-channels and the focusing chamber has a conical frustum shape.

Abstract: An object carrying assembly and a transfer robot. The object carrying assembly (100) comprises: an object carrying component, which comprises two opposite boundary portions; and clamping and bearing members (120), wherein the clamping and bearing members (120) are arranged at the two boundary portions and are rotationally connected to the object carrying component, and the clamping and bearing members (120) are provided with bearing members (121) and clamping claws (122) on two sides of a rotating shaft (130), respectively. When the object carrying component is empty, the bearing members (121) are at least partially higher than a bearing surface of the object carrying component, and when the object carrying component is loaded, the bearing members (121) are not higher than the bearing surface, and the clamping claws (122) are higher than the bearing surface.

Abstract: Provided herein are synthetic living tissue structures comprising multiple layers of fibers deposited in solidified form from a 3D bioprinter, together with kits and methods of use related thereto. The fibers comprise a plurality of mammalian cells dispensed within a solidified biocompatible matrix. The structural integrity of the fiber is maintained upon and after deposition without any additional crosslinking. The fiber is continuously bioprinted through at least two layers of the structure. In one aspect, synthetic muscle tissue structures exhibit a readily assayable contractile functionality.

Abstract: Provided herein are synthetic living tissue structures comprising multiple layers of fibers deposited in solidified form from a 3D bioprinter, together with kits and methods of use related thereto. The fibers comprise a plurality of mammalian cells dispensed within a solidified biocompatible matrix. The structural integrity of the fiber is maintained upon and after deposition without any additional crosslinking. The fiber is continuously bioprinted through at least two layers of the structure. In one aspect, synthetic muscle tissue structures exhibit a readily assayable contractile functionality.

Abstract: An object carrying assembly and a transfer robot. The object carrying assembly (100) comprises: an object carrying component, which comprises two opposite boundary portions; and clamping and bearing members (120), wherein the clamping and bearing members (120) are arranged at the two boundary portions and are rotationally connected to the object carrying component, and the clamping and bearing members (120) are provided with bearing members (121) and clamping claws (122) on two sides of a rotating shaft (130), respectively. When the object carrying component is empty, the bearing members (121) are at least partially higher than a bearing surface of the object carrying component, and when the object carrying component is loaded, the bearing members (121) are not higher than the bearing surface, and the clamping claws (122) are higher than the bearing surface.

Abstract: A print head, system and method for producing hollow fiber structures, for example three-dimensional biological structures comprising living cells, includes a dispensing channel, a core channel converging with the proximal end of the dispensing channel, a first shell channel converging with the core channel and the dispensing channel at a focusing intersection or chamber, and a sheath flow channel converging with the dispensing channel at a sheath flow intersection or chamber located between the focusing intersection or chamber and the distal end of the dispensing channel. The diameter of the dispensing channel increases from a first diameter to a second diameter at the sheath flow intersection or chamber, and the core channel has a third diameter less than the first and second diameters. The sheath flow channel includes sheath flow sub-channels and the focusing chamber has a conical frustum shape.

Abstract: The present invention provides reagents and methods for detecting cancer and precancerous lesions in a patient.

Abstract: The present invention provides reagents and methods for detecting cancer and precancerous lesions in a patient.

Abstract: Provided herein are synthetic living tissue structures comprising multiple layers of fibers deposited in solidified form from a 3D bioprinter, together with kits and methods of use related thereto. The fibers comprise a plurality of mammalian cells dispensed within a solidified biocompatible matrix. The structural integrity of the fiber is maintained upon and after deposition without any additional crosslinking. The fiber is continuously bioprinted through at least two layers of the structure. In one aspect, synthetic muscle tissue structures exhibit a readily assayable contractile functionality.

Abstract: A method in wireless communication systems is provided for switching from P2P (Peer to Peer) communication mode to UP-UTRAN-DOWN (conventional communication mode) and from conventional communication mode to P2P mode, wherein the method performed by a user equipment for switching from P2P communication mode to conventional communication mode comprising steps of: detecting the direct link used by the user equipment in P2P communication with the other user equipment; sending a request for switching to conventional communication mode to a wireless communication network system if the detecting result indicates that the communication quality of the direct link can't satisfy the requirement for P2P communication; and establishing conventional communication connection so as to communicate with said the other user equipment in conventional mode, after receiving the acknowledge (ACK) message of the request for switching sent by the network system.

Abstract: A method for establishing P2P (peer-to-peer) communication in wireless communication networks, comprising steps of: determining whether two user equipments (caller and call) are in the same cell, and computing whether the distance between the two user equipments (UEs) meets the requirement for P2P communication according to the registry information and position information of the caller and the callee; determining whether the two UEs both have P2P communication capability according to the information of the wireless communication system indicating whether the two UEs both have P2P communication capability, when the two UEs are in the same cell and the distance between the two UEs meets the requirement for P2P communication; and allocating direct communication link for the two UEs to start communication when the two UEs both have P2P communication capability.