Patents by Inventor Shengde Zhou
Shengde Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8716002Abstract: The invention provides recombinant bacteria, which comprise a full complement of heterologous ethanol production genes. Expression of the full complement of heterologous ethanol production genes causes the recombinant bacteria to produce ethanol as the primary fermentation product when grown in mineral salts medium, without the addition of complex nutrients. Methods for producing the recombinant bacteria and methods for producing ethanol using the recombinant bacteria are also disclosed.Type: GrantFiled: August 8, 2007Date of Patent: May 6, 2014Assignee: University of Florida Research Foundation, Inc.Inventors: Lorraine P. Yomano, Sean W. York, Shengde Zhou, Keelnatham Shanmugam, Lonnie O. Ingram
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Patent number: 8426191Abstract: The present invention provides derivatives of Escherichia coli constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.Type: GrantFiled: December 7, 2009Date of Patent: April 23, 2013Assignee: University of Florida Research Foundation, Inc.Inventors: Shengde Zhou, Lonnie O'Neal Ingram, Keelnatham T. Shanmugam, Lorraine Yomano, Tammy B. Grabar, Jonathan C. Moore
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Patent number: 8383374Abstract: The subject invention provides materials and methods wherein unique and advantageous combinations of gene mutations are used to direct carbon flow from sugars to a single product. The techniques of the subject invention can be used to obtain products from native pathways as well as from recombinant pathways. In preferred embodiments, the subject invention provides new materials and methods for the efficient production of acetate and pyruvic acid.Type: GrantFiled: June 7, 2011Date of Patent: February 26, 2013Assignee: University of Florida Research Foundation, Inc.Inventors: Thomas B. Causey, Lonnie O'Neal Ingram, Keelnatham Shanmugam, Shengde Zhou
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Publication number: 20110281310Abstract: The subject invention provides materials and methods wherein unique and advantageous combinations of gene mutations are used to direct carbon flow from sugars to a single product. The techniques of the subject invention can be used to obtain products from native pathways as well as from recombinant pathways. In preferred embodiments, the subject invention provides new materials and methods for the efficient production of acetate and pyruvic acid.Type: ApplicationFiled: June 7, 2011Publication date: November 17, 2011Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.Inventors: THOMAS B. CAUSEY, Lonnie O'Neal Ingram, Shengde Zhou, Keelnatham T. Shanmugam
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Patent number: 7977075Abstract: The subject invention provides materials and methods wherein unique and advantageous combinations of gene mutations are used to direct carbon flow from sugars to a single product. The techniques of the subject invention can be used to obtain products from native pathways as well as from recombinant pathways. In preferred embodiments, the subject invention provides new materials and methods for the efficient production of acetate and pyruvic acid.Type: GrantFiled: September 22, 2008Date of Patent: July 12, 2011Assignee: University of Florida Research Foundation, Inc.Inventors: Thomas B. Causey, Lonnie O'Neal Ingram, Keelnatham Shanmugam, Shengde Zhou
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Publication number: 20100203602Abstract: The present invention provides derivatives of Escherichia coli constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.Type: ApplicationFiled: December 7, 2009Publication date: August 12, 2010Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.Inventors: SHENGDE ZHOU, LONNIE O'NEAL INGRAM, KEELNATHAM T. SHANMUGAM, LORRAINE YOMANO, TAMMY B. GRABAR, JONATHAN C. MOORE
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Publication number: 20100112656Abstract: The invention provides recombinant bacteria, which comprise a full complement of heterologous ethanol production genes. Expression of the full complement of heterologous ethanol production genes causes the recombinant bacteria to produce ethanol as the primary fermentation product when grown in mineral salts medium, without the addition of complex nutrients. Methods for producing the recombinant bacteria and methods for producing ethanol using the recombinant bacteria are also disclosed.Type: ApplicationFiled: August 8, 2007Publication date: May 6, 2010Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.Inventors: Lorraine P. Yomano, Sean W. York, Shengde Zhou, Keelnatham Shanmugam, Lonnie O. Ingram
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Patent number: 7629162Abstract: The present invention provides derivatives of ethanologenic Escherichia coli K011 constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.Type: GrantFiled: August 8, 2006Date of Patent: December 8, 2009Assignee: University of Florida Research Foundation, Inc.Inventors: Shengde Zhou, Lonnie O'Neal Ingram, Keelnatham T. Shanmugam, Lorraine Yomano, Tammy B. Grabar, Jonathan C. Moore
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Publication number: 20090148914Abstract: The subject invention provides materials and methods wherein unique and advantageous combinations of gene mutations are used to direct carbon flow from sugars to a single product. The techniques of the subject invention can be used to obtain products from native pathways as well as from recombinant pathways. In preferred embodiments, the subject invention provides new materials and methods for the efficient production of acetate and pyruvic acid.Type: ApplicationFiled: September 22, 2008Publication date: June 11, 2009Inventors: Thomas B. Causey, Lonnie O'Neal Ingram, Shengde Zhou, Keelnathan T. Shanmugam
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Publication number: 20090082600Abstract: A native homoethanol pathway including chromosomal deletions of genes that are competitive with the native homoethanol pathway, and a highly anaerobically expressed pyruvate dehydrogenase operon. Bacteria including the native homoethanol pathway. A method of making a bacteria derivative including a native homoethanol pathway by deleting genes that are competitive with ethanol production pathways, and performing transcriptional gene fusion and highly anaerobically expressing pyruvate dehydrogenase operon. A method of producing ethanol by fermenting bacteria including the native homoethanol pathway with biomass, and producing ethanol. Ethanol produced by the above method.Type: ApplicationFiled: June 5, 2008Publication date: March 26, 2009Inventor: Shengde Zhou
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Patent number: 7226776Abstract: The invention provides recombinant host cells containing at least one heterologous polynucleotide encoding a polysaccharase under the transcriptional control of a surrogate promoter capable of increasing the expression of the polysaccharase. In addition, the invention further provides such hosts with genes encoding secretory protein/s to facilitate the secretion of the expressed polysaccharase. Preferred hosts of the invention are ethanologenic and capable of carrying out simultaneous saccharification fermentation resulting in the production of ethanol from complex cellulose substrates.Type: GrantFiled: February 27, 2003Date of Patent: June 5, 2007Assignee: University of Florida Research Foundation, Inc.Inventors: Lonnie O'Neal Ingram, Shengde Zhou
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Publication number: 20070037265Abstract: The present invention provides derivatives of ethanologenic Escherichia coli K011 constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.Type: ApplicationFiled: August 8, 2006Publication date: February 15, 2007Applicant: University of Florida Research Foundation, Inc.Inventors: Shengde Zhou, Lonnie Ingram, Keelnatham Shanmugam, Lorraine Yomano, Tammy Grabar, Jonathan Moore
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Publication number: 20060110812Abstract: The invention provides compositions and methods for the synergistic degradation of oligosaccharides by endoglucanases. The invention further provides recombinant host cells containing one or more genes encoding endoglucanses which are capable of the synergistic degradation of oligosaccharides.Type: ApplicationFiled: October 7, 2005Publication date: May 25, 2006Applicant: University of Florida Research Foundation, IncInventors: Lonnie O'Neal Ingram, Shengde Zhou
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Patent number: 7026152Abstract: The invention provides compositions and methods for the synergistic degradation of oligosaccharides by endoglucanases. The invention further provides recombinant host cells containing one or more genes encoding endoglucanses which are capable of the synergistic degradation of oligosaccharides. Preferred host cells of the invention are ethanologenic and capable of carrying out simultaneous saccharification and fermentation resulting in the production of ethanol from complex cellulose substrates.Type: GrantFiled: June 19, 2001Date of Patent: April 11, 2006Assignee: University of Florida Research Foundation, Inc.Inventors: Lonnie O'Neal Ingram, Shengde Zhou
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Publication number: 20040152159Abstract: The subject invention provides materials and methods wherein unique and advantageous combinations of gene mutations are used to direct carbon flow from sugars to a single product. The techniques of the subject invention can be used to obtain products from native pathways as well as from recombinant pathways. In preferred embodiments, the subject invention provides new materials and methods for the efficient production of acetate and pyruvic acid.Type: ApplicationFiled: November 6, 2003Publication date: August 5, 2004Inventors: Thomas B. Causey, Lonnie O?apos;Neal Ingram, Shengde Zhou, Keelnathan T. Shanmugam
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Publication number: 20040067555Abstract: The invention provides recombinant host cells containing at least one heterologous polynucleotide encoding a polysaccharase under the transcriptional control of a surrogate promoter capable of increasing the expression of the polysaccharase. In addition, the invention further provides such hosts with genes encoding secretory protein/s to facilitate the secretion of the expressed polysaccharase. Preferred hosts of the invention are ethanologenic and capable of carrying out simultaneous saccharification fermentation resulting in the production of ethanol from complex cellulose substrates.Type: ApplicationFiled: February 27, 2003Publication date: April 8, 2004Applicant: University of Florida Research Foundation, IncorporatedInventors: Lonnie O. Ingram, Shengde Zhou
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Publication number: 20020159990Abstract: The invention provides compositions and methods for the synergistic degradation of oligosaccharides by endoglucanases. The invention further provides recombinant host cells containing one or more genes encoding endoglucanses which are capable of the synergistic degradation of oligosaccharides.Type: ApplicationFiled: June 19, 2001Publication date: October 31, 2002Inventors: Lonnie O?apos;Neal Ingram, Shengde Zhou