Patents by Inventor Shengde Zhou

Shengde Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8716002
    Abstract: The invention provides recombinant bacteria, which comprise a full complement of heterologous ethanol production genes. Expression of the full complement of heterologous ethanol production genes causes the recombinant bacteria to produce ethanol as the primary fermentation product when grown in mineral salts medium, without the addition of complex nutrients. Methods for producing the recombinant bacteria and methods for producing ethanol using the recombinant bacteria are also disclosed.
    Type: Grant
    Filed: August 8, 2007
    Date of Patent: May 6, 2014
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Lorraine P. Yomano, Sean W. York, Shengde Zhou, Keelnatham Shanmugam, Lonnie O. Ingram
  • Patent number: 8426191
    Abstract: The present invention provides derivatives of Escherichia coli constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.
    Type: Grant
    Filed: December 7, 2009
    Date of Patent: April 23, 2013
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Shengde Zhou, Lonnie O'Neal Ingram, Keelnatham T. Shanmugam, Lorraine Yomano, Tammy B. Grabar, Jonathan C. Moore
  • Patent number: 8383374
    Abstract: The subject invention provides materials and methods wherein unique and advantageous combinations of gene mutations are used to direct carbon flow from sugars to a single product. The techniques of the subject invention can be used to obtain products from native pathways as well as from recombinant pathways. In preferred embodiments, the subject invention provides new materials and methods for the efficient production of acetate and pyruvic acid.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: February 26, 2013
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Thomas B. Causey, Lonnie O'Neal Ingram, Keelnatham Shanmugam, Shengde Zhou
  • Publication number: 20110281310
    Abstract: The subject invention provides materials and methods wherein unique and advantageous combinations of gene mutations are used to direct carbon flow from sugars to a single product. The techniques of the subject invention can be used to obtain products from native pathways as well as from recombinant pathways. In preferred embodiments, the subject invention provides new materials and methods for the efficient production of acetate and pyruvic acid.
    Type: Application
    Filed: June 7, 2011
    Publication date: November 17, 2011
    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: THOMAS B. CAUSEY, Lonnie O'Neal Ingram, Shengde Zhou, Keelnatham T. Shanmugam
  • Patent number: 7977075
    Abstract: The subject invention provides materials and methods wherein unique and advantageous combinations of gene mutations are used to direct carbon flow from sugars to a single product. The techniques of the subject invention can be used to obtain products from native pathways as well as from recombinant pathways. In preferred embodiments, the subject invention provides new materials and methods for the efficient production of acetate and pyruvic acid.
    Type: Grant
    Filed: September 22, 2008
    Date of Patent: July 12, 2011
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Thomas B. Causey, Lonnie O'Neal Ingram, Keelnatham Shanmugam, Shengde Zhou
  • Publication number: 20100203602
    Abstract: The present invention provides derivatives of Escherichia coli constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.
    Type: Application
    Filed: December 7, 2009
    Publication date: August 12, 2010
    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: SHENGDE ZHOU, LONNIE O'NEAL INGRAM, KEELNATHAM T. SHANMUGAM, LORRAINE YOMANO, TAMMY B. GRABAR, JONATHAN C. MOORE
  • Publication number: 20100112656
    Abstract: The invention provides recombinant bacteria, which comprise a full complement of heterologous ethanol production genes. Expression of the full complement of heterologous ethanol production genes causes the recombinant bacteria to produce ethanol as the primary fermentation product when grown in mineral salts medium, without the addition of complex nutrients. Methods for producing the recombinant bacteria and methods for producing ethanol using the recombinant bacteria are also disclosed.
    Type: Application
    Filed: August 8, 2007
    Publication date: May 6, 2010
    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Lorraine P. Yomano, Sean W. York, Shengde Zhou, Keelnatham Shanmugam, Lonnie O. Ingram
  • Patent number: 7629162
    Abstract: The present invention provides derivatives of ethanologenic Escherichia coli K011 constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.
    Type: Grant
    Filed: August 8, 2006
    Date of Patent: December 8, 2009
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Shengde Zhou, Lonnie O'Neal Ingram, Keelnatham T. Shanmugam, Lorraine Yomano, Tammy B. Grabar, Jonathan C. Moore
  • Publication number: 20090148914
    Abstract: The subject invention provides materials and methods wherein unique and advantageous combinations of gene mutations are used to direct carbon flow from sugars to a single product. The techniques of the subject invention can be used to obtain products from native pathways as well as from recombinant pathways. In preferred embodiments, the subject invention provides new materials and methods for the efficient production of acetate and pyruvic acid.
    Type: Application
    Filed: September 22, 2008
    Publication date: June 11, 2009
    Inventors: Thomas B. Causey, Lonnie O'Neal Ingram, Shengde Zhou, Keelnathan T. Shanmugam
  • Publication number: 20090082600
    Abstract: A native homoethanol pathway including chromosomal deletions of genes that are competitive with the native homoethanol pathway, and a highly anaerobically expressed pyruvate dehydrogenase operon. Bacteria including the native homoethanol pathway. A method of making a bacteria derivative including a native homoethanol pathway by deleting genes that are competitive with ethanol production pathways, and performing transcriptional gene fusion and highly anaerobically expressing pyruvate dehydrogenase operon. A method of producing ethanol by fermenting bacteria including the native homoethanol pathway with biomass, and producing ethanol. Ethanol produced by the above method.
    Type: Application
    Filed: June 5, 2008
    Publication date: March 26, 2009
    Inventor: Shengde Zhou
  • Patent number: 7226776
    Abstract: The invention provides recombinant host cells containing at least one heterologous polynucleotide encoding a polysaccharase under the transcriptional control of a surrogate promoter capable of increasing the expression of the polysaccharase. In addition, the invention further provides such hosts with genes encoding secretory protein/s to facilitate the secretion of the expressed polysaccharase. Preferred hosts of the invention are ethanologenic and capable of carrying out simultaneous saccharification fermentation resulting in the production of ethanol from complex cellulose substrates.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: June 5, 2007
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Lonnie O'Neal Ingram, Shengde Zhou
  • Publication number: 20070037265
    Abstract: The present invention provides derivatives of ethanologenic Escherichia coli K011 constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.
    Type: Application
    Filed: August 8, 2006
    Publication date: February 15, 2007
    Applicant: University of Florida Research Foundation, Inc.
    Inventors: Shengde Zhou, Lonnie Ingram, Keelnatham Shanmugam, Lorraine Yomano, Tammy Grabar, Jonathan Moore
  • Publication number: 20060110812
    Abstract: The invention provides compositions and methods for the synergistic degradation of oligosaccharides by endoglucanases. The invention further provides recombinant host cells containing one or more genes encoding endoglucanses which are capable of the synergistic degradation of oligosaccharides.
    Type: Application
    Filed: October 7, 2005
    Publication date: May 25, 2006
    Applicant: University of Florida Research Foundation, Inc
    Inventors: Lonnie O'Neal Ingram, Shengde Zhou
  • Patent number: 7026152
    Abstract: The invention provides compositions and methods for the synergistic degradation of oligosaccharides by endoglucanases. The invention further provides recombinant host cells containing one or more genes encoding endoglucanses which are capable of the synergistic degradation of oligosaccharides. Preferred host cells of the invention are ethanologenic and capable of carrying out simultaneous saccharification and fermentation resulting in the production of ethanol from complex cellulose substrates.
    Type: Grant
    Filed: June 19, 2001
    Date of Patent: April 11, 2006
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Lonnie O'Neal Ingram, Shengde Zhou
  • Publication number: 20040152159
    Abstract: The subject invention provides materials and methods wherein unique and advantageous combinations of gene mutations are used to direct carbon flow from sugars to a single product. The techniques of the subject invention can be used to obtain products from native pathways as well as from recombinant pathways. In preferred embodiments, the subject invention provides new materials and methods for the efficient production of acetate and pyruvic acid.
    Type: Application
    Filed: November 6, 2003
    Publication date: August 5, 2004
    Inventors: Thomas B. Causey, Lonnie O?apos;Neal Ingram, Shengde Zhou, Keelnathan T. Shanmugam
  • Publication number: 20040067555
    Abstract: The invention provides recombinant host cells containing at least one heterologous polynucleotide encoding a polysaccharase under the transcriptional control of a surrogate promoter capable of increasing the expression of the polysaccharase. In addition, the invention further provides such hosts with genes encoding secretory protein/s to facilitate the secretion of the expressed polysaccharase. Preferred hosts of the invention are ethanologenic and capable of carrying out simultaneous saccharification fermentation resulting in the production of ethanol from complex cellulose substrates.
    Type: Application
    Filed: February 27, 2003
    Publication date: April 8, 2004
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Lonnie O. Ingram, Shengde Zhou
  • Publication number: 20020159990
    Abstract: The invention provides compositions and methods for the synergistic degradation of oligosaccharides by endoglucanases. The invention further provides recombinant host cells containing one or more genes encoding endoglucanses which are capable of the synergistic degradation of oligosaccharides.
    Type: Application
    Filed: June 19, 2001
    Publication date: October 31, 2002
    Inventors: Lonnie O?apos;Neal Ingram, Shengde Zhou