Abstract: Compositions and methods are provided for potent mRNA vaccines for prevention and treatment of 2019 novel Coronavirus (2019-nCoV) infections. The compositions include a pharmaceutical composition containing one or more mRNA molecules encoding spike protein epitopes, including mutated epitopes, or mRNA cocktails that encode critical viral genes together with pharmaceutically acceptable polymeric nanoparticle carriers and liposomal nanoparticle carriers. Methods for stimulating system immune responses and treatment are provided, including subcutaneous, intraperitoneal and intramuscular injections.

Abstract: Compositions and methods are provided for potent mRNA vaccines for prevention and treatment of 2019 novel Coronavirus (2019-nCoV) infections. The compositions include a pharmaceutical composition containing one or more mRNA molecules encoding spike protein epitopes, including mutated epitopes, or mRNA cocktails that encode critical viral genes together with pharmaceutically acceptable polymeric nanoparticle carriers and liposomal nanoparticle carriers. Methods for stimulating system immune responses and treatment are provided, including subcutaneous, intraperitoneal and intramuscular injections.

Abstract: A handheld high frequency ultrasonic atomizing device for delivering drugs to whole respiratory tract comprising a shell with an air inlet and a lid with a spray nozzle. A drug cup with a piezoelectric transducer and a hood with a spray outlet are provided within the shell. The components of piezoelectric ceramic transducer are as follows (mass percentage): lead tetraoxide 63.3-68.3%, zirconium dioxide 14.2-15.3%, titanium dioxide 8.1-9.5%, strontium oxide 4.6-5.2%, iron sesquioxide 1.5-1.8%, stannic oxide 1.0-1.4%, manganese dioxide 0.3-1.1%, cerium sesquioxide 0.5-0.8%, columbium pentoxide 0.4-0.8% and zinc oxide 0.3-0.7%. This device is small in size, with low power consumption and lower cost, and is able to produce mist with small particle size. The device can efficiently deliver drug liquid into the whole respiratory tract, especially down to the lower respiratory tract and pulmonary alveoli through carrying drug molecules in mist particles.

Abstract: A nebulizer composed of shell with air inlet and lid with spray nozzle. Inside the shell, lays, from bottom to top, a drug cup with piezoelectric transducer and spray chamber with spray outlet. Nebulizer includes vertical air vent lying from bottom air inlet, through middle spray nozzle, to top spray outlet. Moreover, an electric fan lies inside air inlet. Components of piezoelectric ceramic transducer are as follows (mass percentage): lead tetraoxide (Pb3O4, 63.3˜68.3%), zirconium dioxide(ZrO2, 14.2˜15.3%), titanium dioxide (TiO2, 8.1˜9.5%), strontium oxide (SrO, 4.6˜5.2%), iron sesquioxide (Fe2O3, 1.5˜1.8%), stannic oxide (SnO2, 1.0˜1.4%), manganese dioxide (MnO2, 0.3˜1.1%), cerium sesquioxide (Ce2O3, 0.5˜0.8%), columbium pentoxide (Nb2O5, 0.4˜0.8%), zinc oxide (ZnO, 0.3˜0.7%). Nebulizer is small in size, with low power consumption and lower cost, and is able to produce mist with small particle size.