Patents by Inventor Shenghan Chen

Shenghan Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of cardio-renal disease using PCSK6
    Patent number: 10314894
    Abstract: A method of treating a cardio-renal disease is described that includes administering to a subject in need thereof a therapeutically effective amount of proprotein convertase subtilisin/kexin-6 (PCSK6), or an effective fragment thereof, which functions as a corin activator.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: June 11, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Qingyu Wu, Shenghan Chen
  • TREATMENT OF CARDIO-RENAL DISEASE USING PCSK6
    Publication number: 20160058848
    Abstract: A method of treating a cardio-renal disease is described that includes administering to a subject in need thereof a therapeutically effective amount of proprotein convertase subtilisin/kexin-6 (PCSK6), or an effective fragment thereof, which functions as a corin activator.
    Type: Application
    Filed: February 12, 2015
    Publication date: March 3, 2016
    Inventors: Qingyu Wu, Shenghan Chen
  • Corin As A Marker For Heart Failure
    Publication number: 20110306069
    Abstract: The invention is a method of assessing whether an individual is afflicted with congestive heart failure (CHF) comprising comparing the level of corin or portion thereof in the individual to the level of corin or portion thereof in a control, wherein a decrease in the level of corin or portion thereof in the individual compared to the level of corin or portion thereof in the control indicates that the individual is afflicted with CHF. The methods described herein can be also be used to determine the severity of CHF in an individual, whether an individual's treatment for CHF is effective and whether an individual is at risk of developing CHF.
    Type: Application
    Filed: February 19, 2010
    Publication date: December 15, 2011
    Inventors: Qingyu Wu, Shenghan Chen, Edward Plow, Ningzheng Dong, Changgeng Ruan