Patents by Inventor Shengjiang Liu

Shengjiang Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220064618
    Abstract: Angiotensin-converting enzyme 2 (ACE2) has been confirmed as a specific receptor for several (3 group coronaviruses include severe respiratory syndrome (SARS) coronavirus (SARS-CoV-1) and recently the causative agent for the World pandemic CoVID-19, SARS-CoV-2, and low pathogenic coronavirus of HCoV-NL63, a member in ?-coronavirus group. Viral spike protein (S) of viral envelope is confirmed to bind to ACE2 as viral receptor to start a virus replication cycle. The present invention provides ACE2 and its mutants or variants, the viral or non-viral vectors thereof. Methods of treatment of viral infection of a human subject by using such mutants or variants are also provided.
    Type: Application
    Filed: July 6, 2021
    Publication date: March 3, 2022
    Inventor: Shengjiang Liu
  • Publication number: 20220002679
    Abstract: This disclosure relates to methods for use in inactivating viruses. The virus inactivation methods are for use in continuous process manufacturing of a biologic such as an antibody, and include separating an eluate using a column, subjecting said eluate to an orthogonal treatment of low pH and detergent simultaneously wherein, the time for viral inactivation is reduced. In addition, the detergent can be added to buffer system in purification process to achieve the same effect. The biologic in each treatment case is retained.
    Type: Application
    Filed: November 14, 2019
    Publication date: January 6, 2022
    Inventors: Shengjiang LIU, June Xiaojun ZOU, Janice HSIU MEI LEE
  • Publication number: 20200376444
    Abstract: The embodiments provide a modified filter membrane for separating a crude solution of a biological product and a viral contaminant. The filter membrane has a cellulosed based porous surface, and at least one divalent metal ion bound to the cellulose based porous surface of the filter membrane to form a modified filter membrane cellulose based porous surface, wherein the modified cellulose based porous surface separates the crude solution by retaining a viral contaminant greater than 15 nm in diameter while allowing a biological product smaller than 15 nm in diameter to pass through.
    Type: Application
    Filed: February 15, 2019
    Publication date: December 3, 2020
    Inventors: Shengjiang Liu, Wensheng Wang, Ashley Hesslein
  • Publication number: 20200260727
    Abstract: This disclosure relates to methods for use in inactivating viruses. The methods of inactivating viruses with N-methylglucamides is applicable to the purification process of biologically-active drugs such as protein subunits, proteins (enzymes, factors, etc.), recombinant proteins, antibodies, vaccine or gene therapeutic products. The detergents used in this method are based on multiple N-methylglucamide homologs, consisting of a hydrophilic glucose moiety and hydrophobic fatty acid tail, linked by an amide bond. Additionally, these sugar-based detergents are nonionic by nature, which do not disrupt the drug protein, plasma biologies, non-enveloped viral vaccine or adeno associated viral particles.
    Type: Application
    Filed: September 12, 2018
    Publication date: August 20, 2020
    Inventors: SHENGJIANG LIU, ALLISON TITONG, WENSHENG WANG, NICHOLAS SPADONI
  • Publication number: 20110124528
    Abstract: The present invention provides a methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as improved binding affinity towards biologically and/or therapeutically important target molecules. The process is carried out computationally in a high throughput manner by mining the ever-expanding databases of protein sequences of all organisms, especially human.
    Type: Application
    Filed: October 29, 2010
    Publication date: May 26, 2011
    Inventors: Peizhi Luo, Mark Hsieh, Pingyu Zhong, Caili Wang, Yicheng Cao, Shengjiang Liu
  • Patent number: 7429652
    Abstract: The present invention provides a technique for specific assembly of monomeric polypeptides to form a heteromultimer. This technique is particularly useful for generating a genetically diverse repertoire of heteromultimers such as antigen-binding units. The invention also provides both non-single-chain and single-chain antigen-binding units that are assembled by the technique described herein. The present invention also provides recombinant polynucleotides, vectors, host cells, and kits for producing the subject antigen-binding units. Further provided by the invention are methods of using the subject antigen-binding units.
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: September 30, 2008
    Assignee: Abmaxis, Inc.
    Inventors: Caili Wang, Pingyu Zhong, Shengjiang Liu, Peizhi Luo, Shengfeng Li, Xinwei Wang
  • Publication number: 20070037214
    Abstract: The present invention provides a methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as improved binding affinity towards biologically and/or therapeutically important target molecules. The process is carried out computationally in a high throughput manner by mining the ever-expanding databases of protein sequences of all organisms, especially human.
    Type: Application
    Filed: August 10, 2006
    Publication date: February 15, 2007
    Inventors: Peizhi Luo, Mark Hsieh, Pingyu Zhong, Caili Wang, Yicheng Cao, Shengjiang Liu
  • Publication number: 20050009139
    Abstract: The present invention provides a technique for specific assembly of monomeric polypeptides to form a heteromultimer. This technique is particularly useful for generating a genetically diverse repertoire of heteromultimers such as antigen-binding units. The invention also provides both non-single-chain and single-chain antigen-binding units that are assembled by the technique described herein. The present invention also provides recombinant polynucleotides, vectors, host cells, and kits for producing the subject antigen-binding units. Further provided by the invention are methods of using the subject antigen-binding units.
    Type: Application
    Filed: August 3, 2004
    Publication date: January 13, 2005
    Inventors: Caili Wang, Pingyu Zhong, Shengjiang Liu, Peizhi Luo, Shengfeng Li, Xinwei Wang
  • Patent number: 6833441
    Abstract: The present invention provides a technique for specific assembly of monomeric polypeptides to form a heteromultimer. This technique is particularly useful for generating a genetically diverse repertoire of heteromultimers such as antigen-binding units. The invention also provides both non-single-chain and single-chain antigen-binding units that are assembled by the technique described herein. The present invention also provides recombinant polynucleotides, vectors, host cells, and kits for producing the subject antigen-binding units. Further provided by the invention are methods of using the subject antigen-binding units.
    Type: Grant
    Filed: August 1, 2001
    Date of Patent: December 21, 2004
    Assignee: Abmaxis, Inc.
    Inventors: Caili Wang, Pingyu Zhong, Shengjiang Liu, Peizhi Luo, Shengfeng Li, Xinwei Wang
  • Publication number: 20040010376
    Abstract: The present invention provides a methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as improved binding affinity towards biologically and/or therapeutically important target molecules. The process is carried out computationally in a high throughput manner by mining the ever-expanding databases of protein sequences of all organisms, especially human.
    Type: Application
    Filed: May 20, 2003
    Publication date: January 15, 2004
    Inventors: Peizhi Luo, Mark Hsieh, Pingyu Zhong, Caili Wang, Yicheng Cao, Shengjiang Liu
  • Publication number: 20030064053
    Abstract: The present invention provides compositions and methods for treating abnormal cell proliferation and for regulating angiogenesis. In particular, multivalent protein conjugates (MVPs) are constructed to include multiple ligand-binding domains of different receptors and utilized to target multiple, different ligands that are involved in regulation of cell growth and neovascularization. The MVPs of the present invention can be used to treat various conditions associated with abnormal cell proliferation and angiogenesis such as cancer and cardiovascular disorders, as well as to promote wound healing.
    Type: Application
    Filed: August 30, 2002
    Publication date: April 3, 2003
    Inventors: Shengjiang Liu, Jean-Francois Martini, Dayou Liu
  • Publication number: 20030027247
    Abstract: The present invention provides a technique for specific assembly of monomeric polypeptides to form a heteromultimer. This technique is particularly useful for generating a genetically diverse repertoire of heteromultimers such as antigen-binding units. The invention also provides both non-single-chain and single-chain antigen-binding units that are assembled by the technique described herein. The present invention also provides recombinant polynucleotides, vectors, host cells, and kits for producing the subject antigen-binding units. Further provided by the invention are methods of using the subject antigen-binding units.
    Type: Application
    Filed: August 1, 2001
    Publication date: February 6, 2003
    Inventors: Caili Wang, Pingyu Zhong, Shengjiang Liu, Peizhi Luo, Shengfeng Li, Xinwei Wang
  • Publication number: 20030022240
    Abstract: The present invention provides a methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as improved binding affinity towards biologically and/or therapeutically important target molecules. The process is carried out computationally in a high throughput manner by mining the ever-expanding databases of protein sequences of all organisms, especially human. In one embodiment, a method is provided for constructing a library of antibody sequences based on the amino acid sequence of a lead antibody.
    Type: Application
    Filed: May 20, 2002
    Publication date: January 30, 2003
    Inventors: Peizhi Luo, Mark Hsieh, Pingyu Zhong, Caili Wang, Yicheng Cao, Shengjiang Liu