Abstract: This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.

Abstract: A lag detection method includes: obtaining a first image frame and a second image frame in a running process of an application; converting a difference image between the first image frame and the second image frame into a grayscale image; determining, according to grayscale values of pixels in the grayscale image, whether a lag occurs from the first image frame to the second image frame in the running process of the application. A difference image between two image frames in a process video is converted into a grayscale image, and a lag situation between the two image frames is determined by using the grayscale image, so that the lag situation can be determined without the need of obtaining an FPS value in a running process of a terminal application.

Abstract: The present invention discloses a wireless telemetry device for collecting wheel-rail force signals, comprising: a wireless telemetry module, a power supply module, a signal transmission module and a controller. The wireless telemetry module is installed on a wheel axle of a train; a power supply output induction module is installed on a bogie of the train; a power supply receiving induction coil is installed on the wheel axle and electrically connected with the wireless telemetry module; a signal receiving induction module is installed on the bogie of the train; a signal output induction coil is installed on the wheel axle; the controller is installed on the bogie of the train; and the controller realizes signal connection with the signal receiving induction module. In the present invention, the wireless telemetry module and the controller can realize non-contact power transmission and signal transmission.

Abstract: A lag detection method includes: obtaining a first image frame and a second image frame in a running process of an application; converting a difference image between the first image frame and the second image frame into a grayscale image; determining, according to grayscale values of pixels in the grayscale image, whether a lag occurs from the first image frame to the second image frame in the running process of the application. A difference image between two image frames in a process video is converted into a grayscale image, and a lag situation between the two image frames is determined by using the grayscale image, so that the lag situation can be determined without the need of obtaining an FPS value in a running process of a terminal application.

Abstract: The present disclosure provides methods for direct sequencing of RNA, including but not limited to any coding RNA and non-coding RNA such as tRNA, rRNA, mRNA, short or long non-coding RNA as well as any of their modified forms/versions, without the need for generation of a cDNA intermediate and/or intensive sample preparation.

Abstract: This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.

Abstract: This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.

Abstract: The present disclosure relates generally to systems and methods for determining an order of nucleotides of an RNA molecule. The method includes receiving liquid chromatography-mass-spectrometry (LC-MS) data of an RNA sample, filtering the LC-MS data based on mass, the filtering including removing masses smaller than a predetermined size, analyzing the filtered LC-MS data, to determine a plurality of RNA sequences, and reading-out an RNA sequence after determining no remaining valid nucleotides in the remaining LC-MS data. Analyzing the filtered LC-MS data includes determining a mass difference between at least two adjacent ladder fragments, and determining whether the mass difference is equal to a canonical nucleotide, or a modified nucleotide. The LC-MS data including a mass, retention time (RT), and volume. The RNA sequence including a sequence of each identified canonical nucleotide and any identified modified nucleotides.

Abstract: The present disclosure relates generally to novel methods for nucleic acid sequencing. Specifically, the invention relates to a liquid chromatography-mass-spectrometry (LC-MS) based technique for direct sequencing of RNA without cDNA. The technique allows one to simultaneously read an RNA sequence with single nucleotide resolution while determining the presence, type and location of a wide spectrum of RNA modifications.

Abstract: This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.

Abstract: This invention provides novel azido linkers for deoxynucleotide analogs having a detectable marker attached thereto.

Abstract: This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.

Abstract: This invention provides novel azido linkers for deoxynucleotide analogs having a detectable marker attached thereto.

Abstract: This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.

Abstract: This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.

Abstract: This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.

Abstract: This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.