Patents by Inventor Shengwen Li

Shengwen Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ACTIVATABLE CLOSTRIDIAL TOXINS
    Publication number: 20080032930
    Abstract: Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
    Type: Application
    Filed: August 1, 2007
    Publication date: February 7, 2008
    Applicant: Allergan, Inc.
    Inventors: Lance Steward, Joseph Francis, Ester Fernandez-Salas, Marcella Gilmore, Shengwen Li, J. Dolly, Kei Aoki
  • ACTIVATABLE CLOSTRIDIAL TOXINS
    Publication number: 20080032931
    Abstract: Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
    Type: Application
    Filed: August 6, 2007
    Publication date: February 7, 2008
    Inventors: Lance Steward, Joseph Francis, Ester Fernandez-Salas, Marcella Gilmore, Shengwen Li, J. Dolly, Kei Aoki
  • Rescue agents for treating botulinum toxin intoxications
    Patent number: 7172764
    Abstract: The present invention relates to rescue agents for use in the treatments of toxin intoxication—for example botulinum intoxication, which can result from food poisoning, an act of bioterrorism, or from accidental overdose in the course of treatment. In some embodiments, the rescue agents comprise at least one of an inactive botulinum toxin and a modified nontoxic nonhemagglutinin. The present invention also provides for glycosylated active and inactive toxins and methods of using same.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: February 6, 2007
    Assignee: Allergan, Inc.
    Inventors: Shengwen Li, Kei Roger Aoki, Lance E. Steward, Joseph Francis
  • Methods of modulating intracellular degradation rates of toxins
    Publication number: 20060257430
    Abstract: The present invention provides for methods of modulating the degradation rate of a toxin in a cell, thereby modulating the half-life of the toxin. Particularly, the invention features methods of modulating the degradation rate of a toxin by modulating fusion between a lysosome and an endosome that carries the toxin in the cell.
    Type: Application
    Filed: October 25, 2005
    Publication date: November 16, 2006
    Inventors: Shengwen Li, Kei Aoki
  • Novel methods for production of di-chain botulinum toxin
    Publication number: 20060024794
    Abstract: The present invention relates to methods of manufacturing a di-chain botulinum toxin, wherein the methods do not involve the process of producing a single chain botulinum toxin that is followed by nicking to form a di-chain botulinum toxin.
    Type: Application
    Filed: July 30, 2004
    Publication date: February 2, 2006
    Inventors: Shengwen Li, Kei Aoki
  • Methods of modulating intracellular degradation rates of toxins
    Patent number: 6991789
    Abstract: The present invention provides for methods of modulating the degradation rate of a toxin in a cell, thereby modulating the half-life of the toxin. Particularly, the invention features methods of modulating the degradation rate of a toxin by modulating fusion between a lysosome and an endosome that carries the toxin in the cell.
    Type: Grant
    Filed: June 29, 2004
    Date of Patent: January 31, 2006
    Assignee: Allergas, Inc.
    Inventors: Shengwen Li, Kei Roger Aoki
  • METHODS OF MODULATING INTRACELLULAR DEGRADATION RATES OF TOXINS
    Publication number: 20050287175
    Abstract: The present invention provides for methods of modulating the degradation rate of a toxin in a cell, thereby modulating the half-life of the toxin. Particularly, the invention features methods of modulating the degradation rate of a toxin by modulating fusion between a lysosome and an endosome that carries the toxin in the cell.
    Type: Application
    Filed: June 29, 2004
    Publication date: December 29, 2005
    Inventors: Shengwen Li, Kei Aoki
  • Novel DNA sequences of the botulinum neurotoxin complex of Clostridium botulinum type A-Hall (Allergan) strain for production of therapeutics
    Publication number: 20050169942
    Abstract: This invention broadly relates to recombinant DNA technology, molecular biology, neuroscience, and medicine. Particularly, the present invention features novel sequences of the toxin and non-toxin components of the Clostridium botulinum toxin type A-Hall (Allergan) strain complex as well as the expression vector system in a heterologous organism and methods to express such nucleic acid sequences.
    Type: Application
    Filed: October 7, 2004
    Publication date: August 4, 2005
    Applicant: ALLERGAN, INC.
    Inventors: Shengwen Li, Li Zhang, Kei Aoki, Wei-Jen Lin
  • Lipid rafts and clostridial toxins
    Publication number: 20050129677
    Abstract: The present invention is directed to methods of altering the degree of internalization of a Clostridial toxin; methods of preventing or treating botulinum toxin intoxication; methods of treating metabolic disorders, muscular disorders, nervous system disorders, and/or pain conditions; methods of inhibiting the formation of lipid rafts on cell membranes; methods of treating a disease associated with lipid rafts; and methods of identifying a compound that alters the internalization of a Clostridial toxin.
    Type: Application
    Filed: December 10, 2003
    Publication date: June 16, 2005
    Inventors: Shengwen Li, Kei Aoki
  • Rescue agents for treating botulinum toxin intoxications
    Publication number: 20050106182
    Abstract: The present invention relates to rescue agents for use in the treatments of toxin intoxication—for example botulinum intoxication, which can result from food poisoning, an act of bioterrorism, or from accidental overdose in the course of treatment. In some embodiments, the rescue agents comprise at least one of an inactive botulinum toxin and a modified nontoxic nonhemagglutinin. The present invention also provides for glycosylated active and inactive toxins and methods of using same.
    Type: Application
    Filed: November 17, 2003
    Publication date: May 19, 2005
    Inventors: Shengwen Li, Kei Aoki