Abstract: A system for estimating post-virtual stenting fractional flow reserve (FFR) capable of: receiving geometrical parameters of a blood vessel segment, the geometrical parameters comprising first, second and third geometrical parameters; with a proximal end as a reference point, deriving a reference lumen diameter function and calculating a pre-virtual stenting percent diameter stenosis based on the above geometrical parameters and the distance from position along the segment to the reference point; receiving a virtual stenting location; calculating a geometrical parameter of a virtual lumen of the post virtually-stented segment, deriving a post-virtual stenting geometrical parameter difference function and calculating a percent diameter stenosis based on the third geometrical parameter, the virtual stenting location and the reference lumen diameter function; taking derivative difference functions of the post-virtual stenting geometrical parameter difference function in multiple scales; and obtaining FFR based on

Abstract: The invention relates to method and apparatus for reconstructing a three-dimensional representation of a target volume inside an animal or human body. Hereto, according to the method step ii) is preceded by the steps of: a1) displaying said first two-dimensional image projection being obtained in step i) for a user using said displaying means, a2) acquiring a first operational orientation setting of said imaging means corresponding with said first imaging position; a3) defining based on said first operational orientation setting a first set of second operational orientation settings of said imaging means for orientation in a second imaging position; a4) selecting from said set one of said second operational orientation settings; a5) using said second operational orientation setting being selected for acquiring said second two-dimensional image projection of said target volume using said imaging means being positioned in the second imaging position corresponding to said second operational orientation setting.

Abstract: A system for estimating post-virtual stenting fractional flow reserve (FFR) capable of: receiving geometrical parameters of a blood vessel segment, the geometrical parameters comprising first, second and third geometrical parameters; with a proximal end as a reference point, deriving a reference lumen diameter function and calculating a pre-virtual stenting percent diameter stenosis based on the above geometrical parameters and the distance from position along the segment to the reference point; receiving a virtual stenting location; calculating a geometrical parameter of a virtual lumen of the post virtually-stented segment, deriving a post-virtual stenting geometrical parameter difference function and calculating a percent diameter stenosis based on the third geometrical parameter, the virtual stenting location and the reference lumen diameter function; taking derivative difference functions of the post-virtual stenting geometrical parameter difference function in multiple scales; and obtaining FFR based on

Abstract: A method for computing fractional flow reserve (FFR), comprising: receiving geometrical parameters of a blood vessel segment comprising a proximal end and a distal end, the geometrical parameters comprising a first geometrical parameter, a second geometrical parameter and a third geometrical parameter; and with the proximal end as a reference point, deriving a reference lumen diameter function and a geometrical parameter difference function based on the geometrical parameters and the distance from the position along the segment of blood vessel to the reference point. Derivatives of the geometrical parameter difference function are calculated in multiple scales. A maximum mean blood flow velocity of the segment is obtained, and FFR is computed as a ratio of a second blood flow pressure at the first location of the blood vessel to a first blood flow pressure at the proximal end of the segment based on the multiple scales of derivative difference functions and the maximum mean blood flow velocity.

Abstract: The various aspects relate to a method of determining a geometrical parameter of a side branch of a main branch of a blood vessel, comprising receiving a multitude of cross section data sets, the data sets representing geometries of cross sections of the main branch over a length of the main branch and receiving position data of a cut plane of the main branch, the cut plane intersecting the side branch and the cut plane being defined under an angle with the cross-sections. The method further comprises, based on data in at least a part of the cross section data sets, constructing image data of a constructed cross section of the main branch in the cut plane. The method comprises receiving contour data defining a contour in the constructed cross section, the contour being provided in the side branch and determining the parameter by determining a parameter of the contour.

Abstract: Deviations of blood pressure due to stenosis caused by plaque pose a health risk. The deviation, often expressed in a fractional flow reserve, may be calculated on a per-location basis using deviations of the local cross-sectional area or local diameter from a reference value representing a healthy vessel. The reference value may be obtained by means of linear or higher order interpolation or linear regression techniques. Together with the flow velocity of a fluid through the vessel, a value of local deviation of a vessel geometry compared to a reference value allows for accurate, fast and efficient calculation of the fractional flow reserve for every location of the vessel for which geometry data is available. The reference value as well as actual data obtained by measurements may be represented or approximated by functions, allowing accurate and efficient calculation of data over a continuous region of the segment under scrutiny.

Abstract: Deviations of blood pressure due to stenosis caused by plaque pose a health risk. The deviation, often expressed in a fractional flow reserve, may be calculated on a per-location basis using deviations of the local cross-sectional area or local diameter from a reference value representing a healthy vessel. The reference value may be obtained by means of linear or higher order interpolation or linear regression techniques. Together with the flow velocity of a fluid through the vessel, a value of local deviation of a vessel geometry compared to a reference value allows for accurate, fast and efficient calculation of the fractional flow reserve for every location of the vessel for which geometry data is available. The reference value as well as actual data obtained by measurements may be represented or approximated by functions, allowing accurate and efficient calculation of data over a continuous region of the segment under scrutiny.

Abstract: The various aspects relate to a method of determining a geometrical parameter of a side branch of a main branch of a blood vessel, comprising receiving a multitude of cross section data sets, the data sets representing geometries of cross sections of the main branch over a length of the main branch and receiving position data of a cut plane of the main branch, the cut plane intersecting the side branch and the cut plane being defined under an angle with the cross-sections. The method further comprises, based on data in at least a part of the cross section data sets, constructing image data of a constructed cross section of the main branch in the cut plane. The method comprises receiving contour data defining a contour in the constructed cross section, the contour being provided in the side branch and determining the parameter by determining a parameter of the contour.