Abstract: The present application provides the use of an acridinedione compound in the preparation of an antidiabetic medicament, which belongs to the field of biomedical technology. The present application demonstrates for the first time that the acridinedione compound can improve insulin resistance by activating and upregulating GPR40 protein expression, participating in GPR40-PPAR?-PI3K/Akt-GLUT4 signaling pathway, promoting insulin secretion and increasing glucose consumption in liver and muscle tissue. The target of the acridinedione compound is the GPR40 receptor, its insulinotropic effect is glucose-dependent, and its hypoglycemic effect disappears when peripheral blood glucose falls below a certain level. The preparation of the acridinedione compound into an antidiabetic medicaments will provide entirely new options and strategies for the treatment of diabetes.

Abstract: A privacy partition assembly for a cabin environment including a housing, an extension mechanism, and a partition. The extension mechanism has a retracted condition and an extended condition. A leading link moves away from the housing in a first direction when the extension mechanism transitions to the extended condition. The partition has a leading edge engaged with the leading link such that, when the extension mechanism transitions, the leading edge of the partition moves away from the housing. The extension mechanism includes a jointed first arm attached to a first end of the leading link, and a jointed second arm attached to a second end of the leading link. The jointed first and second arms extend when the extension mechanism transitions from the retracted condition to the extended condition thereby moving the leading link away from the housing. A roller maintains the partition in a taut condition.

Abstract: The present invention relates to the technical field of medicine, and specifically relates to a PUMA inhibitor, a method for preparation thereof, and a use thereof. The PUMA inhibitor is the compound as shown in (I) or a pharmaceutically acceptable salt thereof. The definitions of its substituent groups are as described in the description. The compound (I) or pharmaceutically acceptable salt thereof is capable of targeting a PUMA protein and has very good physicochemical properties, very good apoptosis resistance and radiation protection effects; it can selectively inhibit the competitive combined effect of a PUMA protein and a Bcl-2 apoptosis-resistant protein, block apoptosis, and effectively protects against bone marrow damage.

Abstract: A variable speed, self-propelled walk-behind lawnmower includes a housing, a blade housed within the housing for cutting and a handle extending rearwardly from the housing. The handle includes a slidably mounted speed control member movable for adjusting a speed at which a transmission mounted on the housing drives a wheel rotatably mounted to the housing with motive of power from an engine mounted on the housing.