Abstract: This disclosure provides mutant genes related to drug resistance and relapse of acute lymphoblastic leukaemia (ALL) and a use thereof, treatment or prevention of drug resistance and relapse of ALL and a use thereof, a use of compound Lometrexol and related inhibitors targeting GART and AITC in prevention and treatment of drug resistance and relapse of ALL, and a kit for evaluation of the risk of drug resistance and relapse of ALL. The mutation gene is a mutant gene of PRPS1. The drug acts on enzymes in purine synthesis pathway and reduces drug resistance and relapse by decreasing the concentration of hypoxanthine. The kit comprises reagents for lysis of sample cells and an instruction. The invention provides a powerful technical means and support for the prevention and treatment of drug resistance and relapse of ALL.

Abstract: This disclosure provides mutant genes related to drug resistance and relapse of acute lymphoblastic leukaemia (ALL) and a use thereof, treatment or prevention of drug resistance and relapse of ALL and a use thereof, a use of compound Lometrexol and related inhibitors targeting GART and AITC in prevention and treatment of drug resistance and relapse of ALL, and a kit for evaluation of the risk of drug resistance and relapse of ALL. The mutation gene is a mutant gene of PRPS1. The drug acts on enzymes in purine synthesis pathway and reduces drug resistance and relapse by decreasing the concentration of hypoxanthine. The kit comprises reagents for lysis of sample cells and an instruction, wherein the instruction comprises: (i) collection and lysis of the sample cells; (b) determination of the contents of hypoxanthine, IMP, AICAR and Inosine; (c) evaluation of the risk of the drug resistance and relapse of ALL.

Abstract: The present invention provides a method and pavement structure for protecting highway subgrade in frozen soil areas. The pavement structure has two or more pavement layers having gradient thermal conductivity; the thermal conductivity is layered among the pavement layers and is lowered from top to bottom, so that the pavement forms a uni-directional thermal conducting tunnel from the subgrade to the air. Heat can be easily released from the subgrade into the air, and is prevented from being transferred from the air to the subgrade. In this way, the frozen soil layer beneath the subgrade is cooled, so that the frozen soil table is made stable, and the highway subgrade in frozen soil areas is protected.

Abstract: The present invention provides a method and pavement structure for protecting highway subgrade in frozen soil areas. The pavement structure has two or more pavement layers having gradient thermal conductivity; the thermal conductivity is layered among the pavement layers and is lowered from top to bottom, so that the pavement forms a uni-directional thermal conducting tunnel from the subgrade to the air. Heat can be easily released from the subgrade into the air, and is prevented from being transferred from the air to the subgrade. In this way, the frozen soil layer beneath the subgrade is cooled, so that the frozen soil table is made stable, and the highway subgrade in frozen soil areas is protected.