Patents by Inventor Shenheng Guan
Shenheng Guan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20050016276Abstract: A method for the detection of analytes using resonant mass sensors or sensor arrays comprises frequency encoding each sensor element, acquiring a time-domain resonance signal from the sensor or sensor array as it is exposed to analyte, detecting change in the frequency or resonant properties of each sensor element using a Fourier transform or other spectral analysis method, and classifying, identifying, and/or quantifying analyte using an appropriate data analysis procedure. Frequency encoded sensors or sensor arrays comprise sensor elements with frequency domain resonance signals that can be uniquely identified under a defined range of operating conditions. Frequency encoding can be realized either by fabricating individual sensor elements with unique resonant frequencies or by tuning or modifying identical resonant devices to unique frequencies by adding or removing mass from individual sensor elements.Type: ApplicationFiled: June 4, 2004Publication date: January 27, 2005Applicant: Palo Alto Sensor Technology InnovationInventors: Shenheng Guan, Ralph Nielsen
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Publication number: 20050009175Abstract: A chemical processing microsystem useful for identifying and optimizing materials (e.g., catalysts) that enhance chemical processes or for characterizing and/or optimizing chemical processes is disclosed. The chemical processing microsystem comprises a plurality of microreactors 600 and, in a preferred embodiment, a plurality of microseparators 900 integral with the chemical processing microsystem 10. The microreactors 600 are preferably diffusion-mixed microreactors formed in a plurality of laminae that include a modular, interchangeable candidate-material array 100. The material array 100 comprises a plurality of different candidate materials (e.g., catalysts), preferably arranged at separate, individually addressable portions of a substrate (e.g., wafer). The microseparators 900 are similarly formed in a plurality of laminae that include a modular, interchangeable adsorbent array 700.Type: ApplicationFiled: August 5, 2004Publication date: January 13, 2005Inventors: H. Bergh, Shenheng Guan
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Publication number: 20040139784Abstract: Gas chromatographs of the invention generally comprise four or more analysis channels. Specifically, four or more gas chromatography columns are configured for parallel analysis of four or more gaseous samples with detection being effected using a microdetector array comprising four or more microdetectors. In one embodiment, the four or more microdetectors 510 are microfabricated detectors, and are integrally formed with a substrate or with one or more microchip bodies mounted on a substrate. In a preferred embodiment, a microdetector array comprises four or more thermal conductivity detectors having one or more thin-film detection filaments. A preferred heated environment for highly parallel gas chromatographs is also disclosed.Type: ApplicationFiled: November 20, 2003Publication date: July 22, 2004Applicant: Symyx Technologies, Inc.Inventors: Ravi Srinivasan, Daniel Meron Pinkas, Shenheng Guan, Michael Myslovaty, Mikhail Spitkovsy, James R. Engstrom, H. Sam Bergh
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Patent number: 6749814Abstract: A chemical processing microsystem useful for identifying and optimizing materials (e.g., catalysts) that enhance chemical processes or for characterizing and/or optimizing chemical processes is disclosed. The chemical processing microsystem comprises a plurality of microreactors 600 and, in a preferred embodiment, a plurality of microseparators 900 integral with the chemical processing microsystem 10. The microreactors 600 are preferably diffusion-mixed microreactors formed in a plurality of laminae that include a modular, interchangeable candidate-material array 100. The material array 100 comprises a plurality of different candidate materials (e.g., catalysts), preferably arranged at separate, individually addressable portions of a substrate (e.g., wafer). The microseparators 900 are similarly formed in a plurality of laminae that include a modular, interchangeable adsorbent array 700.Type: GrantFiled: March 3, 2000Date of Patent: June 15, 2004Assignee: Symyx Technologies, Inc.Inventors: H. Sam Bergh, Shenheng Guan
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Patent number: 6737026Abstract: A chemical processing microsystem useful for identifying and optimizing materials (e.g., catalysts) that enhance chemical processes or for characterizing and/or optimizing chemical processes is disclosed. The chemical processing microsystem comprises a plurality of microreactors 600 and, in a preferred embodiment, a plurality of microseparators 900 integral with the chemical processing microsystem 10. The microreactors 600 are preferably diffusion-mixed microreactors formed in a plurality of laminae that include a modular, interchangeable candidate-material array 100. The material array 100 comprises a plurality of different candidate materials (e.g., catalysts), preferably arranged at separate, individually addressable portions of a substrate (e.g., wafer). The microseparators 900 are similarly formed in a plurality of laminae that include a modular, interchangeable adsorbent array 700.Type: GrantFiled: November 28, 2000Date of Patent: May 18, 2004Assignee: Symyx Technologies, Inc.Inventors: H. Sam Bergh, Shenheng Guan
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Patent number: 6701774Abstract: Gas chromatographs of the invention generally comprise four or more analysis channels. Specifically, four or more gas chromatography columns are configured for parallel analysis of four or more gaseous samples with detection being effected using a microdetector array comprising four or more microdetectors. In one embodiment, the four or more microdetectors 510 are microfabricated detectors, and are integrally formed with a substrate or with one or more microchip bodies mounted on a substrate. In a preferred embodiment, a microdetector array comprises four or more thermal conductivity detectors having one or more thin-film detection filaments. A preferred heated environment for highly parallel gas chromatographs is also disclosed.Type: GrantFiled: March 7, 2001Date of Patent: March 9, 2004Assignee: Symyx Technologies, Inc.Inventors: Ravi Srinivasan, Daniel Meron Pinkas, Shenheng Guan, Michael Myslovaty, Michael Spitkovsky, James R. Engstrom, H. Sam Bergh
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Publication number: 20020170976Abstract: Parallel flow chemical processing systems, such as parallel flow chemical reaction systems are disclosed. These systems are adapted to simultaneously and independently vary temperature between separate flow channels, preferably by employing separate, individual heating elements in thermal communication with each of four or more parallel flow reactors. The flow reactors are preferably isolated from each other using a thermal isolation system comprising fluid-based heat exchange. In preferred embodiments, the axial heat flux can be fixedly or controllably varied.Type: ApplicationFiled: March 7, 2002Publication date: November 21, 2002Inventors: H. Sam Bergh, Shenheng Guan, James R. Engstrom, Steffen Hardt, Astrid Lohf, Frank Michel
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Publication number: 20020141900Abstract: The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of vessels for containing individual library members and a fluid handling system that apportions a test fluid about equally between each of the vessels. This allows for simultaneous screening of library members by detecting changes in test fluid following contact with individual library members. Fluid flow through each of the vessels is controlled using passive flow restrictors or active flow controllers to ensure that each library member contacts approximately the same amount of test fluid per unit time. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.Type: ApplicationFiled: February 8, 2002Publication date: October 3, 2002Inventors: Shenheng Guan, Lynn Van Erden, Robert C. Haushalter, Xiao Ping Zhou, Xuejun Jason Wang, Ravi Srinivasan
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Publication number: 20020048536Abstract: Parallel flow reaction systems comprising four or more reaction channels are disclosed. Distribution systems, and parallel flow reaction systems comprising such distribution systems are also disclosed. Specifically, the distribution systems comprise one or more subsystems, including for example, a flow-partitioning subsystem for providing a different flow rate to each of the four or more reactors, a pressure-partitioning subsystem for providing a different reaction pressure in the reaction cavity of each of the four or more reactors, and a feed-composition subsystem for providing a different feed composition to each of the four or more reactors. In preferred embodiments, the one or more subsystems can comprise at least one set of four or more flow restrictors, each of the four or more flow restrictors having a flow resistance that varies relative to other flow restrictors in the set.Type: ApplicationFiled: March 7, 2001Publication date: April 25, 2002Inventors: H. Sam Bergh, James R. Engstrom, Shenheng Guan, Daniel Meron Pinkas, Kyle W. Self
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Publication number: 20020045265Abstract: Parallel flow reaction systems comprising four or more reaction channels are disclosed. Distribution systems, and parallel flow reaction systems comprising such distribution systems are also disclosed. Specifically, the distribution systems comprise a feed-composition subsystem for providing a different feed composition to each of the four or more reactors. In preferred embodiments, the feed composition subsystem comprises at least one set of four or more feed-component flow restrictors, each of the four or more feed-component flow restrictors having a flow resistance that varies relative to other flow restrictors in the set.Type: ApplicationFiled: March 8, 2001Publication date: April 18, 2002Inventors: H. Sam Bergh, James R. Engstrom, Shenheng Guan, Daniel Meron Pinkas, Kyle W. Self
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Publication number: 20020042140Abstract: Protocols for designing and implementing sets of simultaneous experiments, in a parallel, multi-variable process optimization reactor, are disclosed. The multi-variable process optimization reactor is preferably a parallel flow reactor having the operational capability to simultaneously vary reaction conditions between reaction vessels—either modularly or independently. The simultaneously varied reaction conditions preferably include at least two of the following, in various combinations and permutations: space velocity, contact time, temperature, pressure and feed composition. Compositional variations in the catalysts residing in each of the reaction vessels can also be investigated in the set of simultaneous experiments implemented in the parallel reactor. Sufficient data is obtained from a single set of simultaneous experiments to generate a master curve.Type: ApplicationFiled: July 9, 2001Publication date: April 11, 2002Inventors: Alfred Hagemeyer, Anthony F. Volpe, Claus Lugmair, David M. Lowe, Yumin Liu, H. Sam Bergh, Shenheng Guan, Daniel M. Pinkas, Kyle W. Self, James R. Engstrom, Laurent Lefort
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Publication number: 20020014106Abstract: Gas chromatographs of the invention generally comprise four or more analysis channels. Specifically, four or more gas chromatography columns are configured for parallel analysis of four or more gaseous samples with detection being effected using a microdetector array comprising four or more microdetectors. In one embodiment, the four or more microdetectors 510 are microfabricated detectors, and are integrally formed with a substrate or with one or more microchip bodies mounted on a substrate. In a preferred embodiment, a microdetector array comprises four or more thermal conductivity detectors having one or more thin-film detection filaments. A preferred heated environment for highly parallel gas chromatographs is also disclosed.Type: ApplicationFiled: March 7, 2001Publication date: February 7, 2002Inventors: Ravi Srinivasan, Daniel Meron Pinkas, Shenheng Guan, Michael Myslovaty, Mikhail Spitkovsky, James R. Engstrom, H. Sam Bergh
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Patent number: 6149882Abstract: The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of vessels for containing individual library members and a fluid handling system that apportions a test fluid about equally between each of the vessels. This allows for simultaneous screening of library members by detecting changes in test fluid following contact with individual library members. Fluid flow through each of the vessels is controlled using passive flow restrictors or active flow controllers to ensure that each library member contacts approximately the same amount of test fluid per unit time. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.Type: GrantFiled: June 9, 1998Date of Patent: November 21, 2000Assignee: Symyx Technologies, Inc.Inventors: Shenheng Guan, Lynn Van Erden, Robert C. Haushalter, Xiao Ping Zhou, Xuejun Jason Wang, Ravi Srinivasan
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Patent number: 5959297Abstract: Methods and apparatus for screening diverse arrays of materials are provided. Techniques are provided for rapidly characterizing compounds in combinatorial arrays of materials for discovering and/or optimizing new materials with specific desired properties. A scanning mass spectrometer is used which includes an ionization chamber and a collector that outputs an electrical signal responsive to the quantity of gas ions contacting the collector surface. A conduit system selectively withdraws samples from the array of materials, passing the samples into the ionization chamber. In a specific embodiment, reactants are passed through the conduit system to the selected regions of interest on the substrate.Type: GrantFiled: October 8, 1997Date of Patent: September 28, 1999Assignee: Symyx TechnologiesInventors: W. Henry Weinberg, Eric W. McFarland, Peijun Cong, Shenheng Guan
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Patent number: 5013912Abstract: A method for reducing the dynamic range of FT-ICR signal generated by the SWIFT technique includes the step of time shifting wave packets corresponding to segments of the Fourier spectral magnitude function to prevent coherent summing of the various frequency components of the excitation signal.Type: GrantFiled: July 14, 1989Date of Patent: May 7, 1991Assignee: University of the PacificInventors: Shenheng Guan, Patrick R. Jones
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Patent number: 4956788Abstract: An apparatus for conducting FT/ICR experimentation and acquiring data using a personal computer and a fast buffer board. The apparatus has the capability of generating an ion excitation signal and acquiring results from the FT/ICR experiment. Those results are then digitized and stored in memory on the fast buffer board. Once the results have been stored in the fast buffer board memory, they are transferred to the personal computer where they can be processed and interpreted by the user.Type: GrantFiled: November 28, 1988Date of Patent: September 11, 1990Assignee: University of the PacificInventors: Shenheng Guan, Patrick R. Jones