Patents by Inventor Shenlin Huang

Shenlin Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
    Publication number: 20090048249
    Abstract: The present invention is directed to novel 3-benzoimidazolyl-pyrazolopyridine compounds of formula (I): and pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of serine-threonine protein kinases and tyrosine protein kinases and interactions thereof.
    Type: Application
    Filed: May 31, 2006
    Publication date: February 19, 2009
    Inventors: George Chiu, Peter J. Connolly, Stuart Emanuel, Shenlin Huang, Shengjian Li, Ronghui Lin, Yanhua Lu, Steven A. Middleton
  • SUBSTITUTED BENZOTHIAZOLE KINASE INHIBITORS
    Publication number: 20080293785
    Abstract: The present invention is directed to substituted benzothiazole compounds of formula (I): and forms thereof, their synthesis and use for treating a chronic or acute protein kinase mediated disease, disorder or condition.
    Type: Application
    Filed: April 10, 2007
    Publication date: November 27, 2008
    Inventors: Peter J. Connolly, Stuart L. Emanuel, Shenlin Huang, Ignatius J. Turchi
  • HYDRAZONE DERIVATIVES AS KINASE INHIBITORS
    Publication number: 20080114004
    Abstract: The present invention is directed to novel bicyclic pyrimidine compounds of Formula (I) or a form or composition thereof as inhibitors of ATP-protein kinase interactions, wherein substituents on each side of the iminomethyl double bond in Formula (I) may be in the E or Z configuration; and wherein R1, R2, R3 and R4 are as defined herein.
    Type: Application
    Filed: October 12, 2007
    Publication date: May 15, 2008
    Inventors: Guozhang Xu, Lily Searle, Shenlin Huang
  • Substituted triazole diamine derivatives as kinase inhibitors
    Patent number: 7317031
    Abstract: The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: February 1, 2005
    Date of Patent: January 8, 2008
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Ronghui Lin, Shenlin Huang, Steven K. Wetter, Peter J. Connolly, Stuart L. Emanuel, Robert H. Gruninger, Steven A. Middleton
  • SUBSTITUTED PYRIMIDINE KINASE INHIBITORS
    Publication number: 20070254896
    Abstract: The present invention is directed to substituted pyrimidine compounds of formula (I): and forms thereof, their synthesis and use for treating a chronic or acute protein kinase mediated disease, disorder or condition.
    Type: Application
    Filed: March 23, 2007
    Publication date: November 1, 2007
    Inventors: Jeannene Butler, Peter Connolly, Angel Fuentes-Pesquera, Lee Greenberger, Shenlin Huang, Kenneth LaMontagne, Ronghua Li, Guozhang Xu
  • Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders
    Publication number: 20060183900
    Abstract: The present invention provides pyrimidinyl substituted fused-pyrrolyl compounds of Formula (I) and pharmaceutical compositions comprising the compounds and methods of synthesis and use thereof. The compounds are kinase inhibitors useful in treating or ameliorating a kinase mediated, angiogenesis-mediated or hyperproliferative disorder. The invention thus also provides a therapeutic or prophylactic method of use for the compounds and/or pharmaceutical compositions to treat such disorders.
    Type: Application
    Filed: October 28, 2005
    Publication date: August 17, 2006
    Inventors: Shenlin Huang, Ronghui Lin, Peter Connolly, Stuart Emanuel, Steven Middleton
  • 1,2,4-Triazolylaminoaryl (heteroaryl) sulfonamide derivatives
    Publication number: 20060173020
    Abstract: 1,2,4-Triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I), pharmaceutically acceptable salts thereof, processes for the manufacture of 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives and pharmaceutical compositions containing 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives are disclosed: The 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I) possess cell cycle inhibitory activity and are accordingly useful for their anti cell proliferation (such as anti cancer) activity.
    Type: Application
    Filed: October 6, 2005
    Publication date: August 3, 2006
    Inventors: Shenlin Huang, Ronghui Lin, Peter Connolly, Stuart Emanuel, Steven Middleton, Robert Gruninger, Steven Wetter
  • Short synthesis of pyridine-based pharmaceutical intermediates
    Patent number: 6987189
    Abstract: A method of making a compound of Formula VI: wherein Tr is a triphenyl group; R1, R2 and R3 are each independently selected from the group consisting of H, C1–C4 alkyl, C1–C4 alkoxy, aryl, heteroaryl, and arylalkyl; R4 is C2–C6 alkyl, and R5 and R6 are each independently H or C1–C4 alkyl, involves the step of reacting a compound of Formula V: with Tr-OH to produce a compound of Formula VI. The compounds of Formula VI are useful as intermediates in the manufacture of antibiotic agents. Methods of making compounds of Formula V, and intermediates made or used in the foregoing methods, are also described.
    Type: Grant
    Filed: September 28, 2004
    Date of Patent: January 17, 2006
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Shenlin Huang
  • Substituted triazole diamine derivatives as kinase inhibitors
    Publication number: 20050182116
    Abstract: The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: February 1, 2005
    Publication date: August 18, 2005
    Inventors: Ronghui Lin, Shenlin Huang, Steven Wetter, Peter Connolly, Stuart Emanuel, Robert Gruninger, Steven Middleton
  • Substituted triazole diamine derivatives as kinase inhibitors
    Patent number: 6924302
    Abstract: The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: August 2, 2005
    Assignee: Ortho McNeil Pharmaceutical, Inc.
    Inventors: Ronghui Lin, Peter J. Connolly, Steven K. Wetter, Shenlin Huang, Stuart L. Emanuel, Robert H. Gruninger, Steven A. Middleton
  • Short synthesis of pyridine-based pharmaceutical intermediates
    Publication number: 20050065347
    Abstract: A method of making a compound of Formula VI: wherein Tr is a triphenyl group; R1, R2 and R3 are each independently selected from the group consisting of H, C1-C4 alkyl, C1-C4 alkoxy, aryl, heteroaryl, and arylalkyl; R4 is C2-C6 alkyl, and R5 and R6 are each independently H or C1-C4 alkyl, involves the step of reacting a compound of Formula V: with Tr-OH to produce a compound of Formula VI. The compounds of Formula VI are useful as intermediates in the manufacture of antibiotic agents. Methods of making compounds of Formula V, and intermediates made or used in the foregoing methods, are also described.
    Type: Application
    Filed: September 28, 2004
    Publication date: March 24, 2005
    Inventors: Daniel Comins, Shenlin Huang
  • Short synthesis of pyridine-based pharmaceutical intermediates
    Patent number: 6855825
    Abstract: A method of making a compound of Formula VI: wherein Tr is a triphenyl group; R1, R2 and R3 are each independently selected from the group consisting of H, C1-C4 alkyl, C1-C4 alkoxy, aryl, heteroaryl, and arylalkyl; R4 is C2-C6 alkyl, and R5 and R6 are each independently H or C1-C4 alkyl, involves the step of reacting a compound of Formula V: with Tr-OH to produce a compound of Formula VI. The compounds of Formula VI are useful as intermediates in the manufacture of antibiotic agents. Methods of making compounds of Formula V, and intermediates made or used in the foregoing methods, are also described.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: February 15, 2005
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Shenlin Huang
  • Short synthesis of pyridine-based pharmaceutical intermediates
    Publication number: 20040138463
    Abstract: A method of making a compound of Formula VI: 1
    Type: Application
    Filed: December 18, 2003
    Publication date: July 15, 2004
    Inventors: Daniel L. Comins, Shenlin Huang
  • Substituted triazole diamine derivatives as kinase inhibitors
    Publication number: 20040077699
    Abstract: The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: December 21, 2001
    Publication date: April 22, 2004
    Inventors: Ronghui Lin, Peter J. Connolly, Steven K. Wetter, Shenlin Huang, Stuart L. Emanuel, Robert H. Gruninger, Steve A. Middleton
  • Short synthesis of pyridine-based pharmaceutical intermediates
    Patent number: 6706884
    Abstract: A method of making a compound of Formula VI: wherein Tr is a triphenyl group; R1, R2 and R3 are each independently selected from the group consisting of H, C1-C4 alkyl, C1-C4 alkoxy, aryl, heteroaryl, and arylalkyl; R4 is C2-C6 alkyl, and R5 and R6 are each independently H or C1-C4 alkyl, involves the step of reacting a compound of Formula V: with Tr—OH to produce a compound of Formula VI. The compounds of Formula VI are useful as intermediates in the manufacture of antibiotic agents. Methods of making compounds of Formula V, and intermediates made or used in the foregoing methods, are also described.
    Type: Grant
    Filed: December 16, 2002
    Date of Patent: March 16, 2004
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Shenlin Huang
  • Short synthesis of pyridine-based pharmaceutical intermediates
    Publication number: 20030166941
    Abstract: A method of making a compound of Formula VI: 1
    Type: Application
    Filed: December 16, 2002
    Publication date: September 4, 2003
    Inventors: Daniel L. Comins, Shenlin Huang
  • Short synthesis of pyridine-based pharmaceutical intermediates
    Patent number: 6534656
    Abstract: A method of making a compound of Formula VI: wherein Tr is a triphenyl group; R1, R2 and R3 are each independently selected from the group consisting of H, C1-C4 alkyl, C1-C4 alkoxy, aryl, heteroaryl, and arylalkyl; R4 is C2-C6 alkyl, and R5 and R6 are each independently H or C1-C4 alkyl, involves the step of reacting a compound of Formula V: with Tr-OH to produce a compound of Formula VI. The compounds of Formula VI are useful as intermediates in the manufacture of antibiotic agents. Methods of making compounds of Formula V, and intermediates made or used in the foregoing methods, are also described.
    Type: Grant
    Filed: May 31, 2001
    Date of Patent: March 18, 2003
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Shenlin Huang
  • Short synthesis of pyridine-based pharmaceutical intermediates
    Publication number: 20020193606
    Abstract: A method of making a compound of Formula VI: 1
    Type: Application
    Filed: May 31, 2001
    Publication date: December 19, 2002
    Inventors: Daniel L. Comins, Shenlin Huang