Abstract: Provided is a method for preparing 4-(hydroxymethylphosphinyl)-2-oxobutanoic acid, comprising the following steps: a) mixing methylphosphonite diester, carboxylic acid and acryloyl cyanide, performing addition reaction, and performing distillation under reduced pressure to obtain a material solution of (3-cyano-3-carbonylpropyl)methylphosphonate; b) mixing the material solution of (3-cyano-3-carbonylpropyl)methylphosphonate obtained in step a) with water uniformity, cooling to 10° C.-40° C., then adding hydrochloric acid dropwise for acidification, and after the dropwise addition being completed, continuing stirring for 0.1 h-1 h, then performing hydrolysis reaction, and finally performing purification treatment to obtain 4-(hydroxymethylphosphinyl)-2-oxobutanoic acid. In the provided preparation method, cyanation reaction is not required, which avoids the use of cyclic phosphonic anhydride that is high in cost and difficult to obtain and the highly toxic sodium cyanide.

Abstract: The present invention provides a method for preparing 4-(hydroxymethylphosphinyl)-2-oxobutanoic acid, comprising the following steps: a) mixing acryloyl chloride, a first solvent, a polymerization inhibitor, a catalyst and potassium ferrocyanide, performing a substitution reaction, and performing distillation under reduced pressure to obtain an acryloyl cyanide intermediate; b) mixing the acryloyl cyanide intermediate obtained in step a) with hydrochloric acid and a polymerization inhibitor, performing a hydrolysis reaction, and then performing purification treatment to obtain crude 2-carbonyl-3-butenoic acid; c) mixing the crude 2-carbonyl-3-butenoic acid obtained in step b) with a second solvent and methyldichlorophosphine, and performing an addition reaction to obtain a solution containing diacyl chloride; d) mixing the solution containing diacyl chloride obtained in step c) with water, performing a hydrolysis reaction, and performing purification to obtain 4-(hydroxymethylphosphinyl)-2-oxobutanoic acid.

Abstract: A method for preparing 4-(hydroxymethylphosphinyl)-2-oxobutanoic acid, comprising the following steps: a) mixing 3-chloropropionyl chloride, a first solvent, trimethylsilyl cyanide and cyanide salt, performing a substitution reaction to obtain a material solution containing 4-chloro-2-oxobutyronitrile, then performing distillation under reduced pressure, and performing separation to obtain 4-chloro-2-oxobutyronitrile intermediate; b) subjecting the 4-chloro-2-oxobutyronitrile intermediate obtained in step a) and methyl phosphonite diester to Arbuzov reaction in a second solvent in the presence of cuprous iodide to obtain a material solution of (3-cyano-3-oxopropyl) methyl phosphinate, and performing purification to obtain crude (3-cyano-3-oxopropyl) methyl phosphinate; c) mixing the obtained crude (3-cyano-3-oxopropyl)methyl phosphinate with hydrochloric acid, performing hydrolysis reaction, and then performing purification treatment to obtain 4-(hydroxymethylphosphinyl)-2-oxobutanoic acid.

Abstract: The present application discloses a multi-region plasma shell-and-tube reactor comprising a shell body. At least two reaction regions are provided inside the shell body, and a horizontal separation panel is provided between any two adjacent reaction regions, used to separate the two and passing through the tubes. A central hole is provided in the center of any horizontal separation panel, and at least one auxiliary hole distributed around the central axis of the central hole is provided in any horizontal separation panel so as to cooperate with the central hole to cause a vortex state to be formed in a reaction region.

Abstract: The present invention provides a system for continuously producing diethyl methylphosphonite, comprising a rapid mixing reactor and a material circulation subsystem. An inlet of the rapid mixing reactor is provided with a rapid mixing component; the rapid mixing component comprises a first liquid inlet and a second liquid inlet: the second liquid inlet is used for feeding a material containing methylphosphonous dichloride; the material circulation subsystem comprises a filter, a material distribution unit, an acid binding agent premixer and a heat exchanger, which are connected in sequence; the filter is also provided with a solid waste outlet; the material distribution unit is also provided with a diethyl methylphosphonite outlet; the acid binding agent premixer is also provided with a reaction raw material inlet and an acid binding agent inlet; an inlet of the filter is connected to an outlet of the rapid mixing reactor; and an outlet of the heat exchanger is connected to the first liquid inlet.

Abstract: The present application discloses a multi-region plasma shell-and-tube reactor comprising a shell body. At least two reaction regions are provided inside the shell body, and a horizontal separation panel is provided between any two adjacent reaction regions, used to separate the two and passing through the tubes. A central hole is provided in the center of any horizontal separation panel, and at least one auxiliary hole distributed around the central axis of the central hole is provided in any horizontal separation panel so as to cooperate with the central hole to cause a vortex state to be formed in a reaction region.