Abstract: Described herein are compounds of Formula I, wherein the variables are defined herein, their use as activators from AMPK, pharmaceutical compositions containing such compounds and their use to treat, for example, heart failure or peripheral vascular disease.

Abstract: Described herein are compounds of Formula I, wherein the variables are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, diabetes, kidney disease, NASH and heart failure.

Abstract: According to one embodiment two-core optical fiber is provided for use in Brillouin distributed fiber sensor applications and systems. The two-core fiber includes a first and second core. Each core is configured to exhibit a Brillouin frequency shift greater than 30 Mhz relative to the other core. Further, each core possesses temperature and strain coefficients that differ from the other core. The cores can be configured to produce Brillouin frequency shift levels of at least 30 Mhz relative to one another. These differences in shift levels may be affected by adjustment of the material compositions, doping concentrations and/or refractive index profiles of each of the cores. These optical fibers may also be used in BOTDR- and BOTDA-based sensor systems and arrangements.

Abstract: The present invention relates to methods of facilitating death of cancer cells in a subject by inhibiting tissue transglutaminase in the subject under conditions effective to facilitate death of cancer cells. Also disclosed are methods for identifying candidate compounds suitable for facilitating death of cancer cells in a subject by contacting tissue transglutaminase with a compound and identifying those compounds which bind to the tissue transglutaminase as candidate compounds suitable for facilitating death of cancer cells in a subject. The present invention also discloses methods of producing a tissue transglutaminase crystal suitable for X-ray diffraction as well as crystals produced by such methods. Also disclosed are compounds suitable for facilitating death of cancer cells in a subject as well as methods for designing such compounds.