Abstract: Described herein are compounds that can arrest mitotic cells and their use in the treatment of disorders such as cancers.

Abstract: In certain aspects, disclosed herein are methods of treating cancer in a subject, comprising administration to the subject of (1) one or more glucocorticoid receptor agonists and (2) one or more inhibitors of calcineurin. In some embodiments, the administration of the one or more glucocorticoid receptor agonists and the one or more inhibitors of calcineurin results in restoration of contact inhibition, increased formation of intercellular junctions, reduced cell proliferation, and/or increased vacuolization of cells growing in multilayer zones. Included herein are methods for identification of novel compounds that restore contact inhibition in cancer cells.

Abstract: The disclosure provides a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, and R4 are as described herein. The disclosure also provides methods for identifying a compound that selectively kills polyploid cells, and methods for killing polyploid tumor cells by administering a compound of Formula Ito a patient in need thereof.

Abstract: The disclosure provides a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, and R4 are as described herein. The disclosure also provides methods for identifying a compound that selectively kills polyploid cells, and methods for killing polyploid tumor cells by administering a compound of Formula I to a patient in need thereof.

Abstract: The disclosure provides a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, and R4 are as described herein. The disclosure also provides methods for identifying a compound that selectively kills polyploid cells, and methods for killing polyploid tumor cells by administering a compound of Formula I to a patient in need thereof.

Abstract: The present invention generally relates to inhibitor compounds and their use to selectively kill a class of cancer cells. Methods and means related to the treatment of cancers which overexpress the MYC family of oncogenes using Rho-associated protein kinase inhibitors, such as dimethylfasudil, which have shown to elicit cellular apoptosis, are provided herein.

Abstract: Techniques are provided, which may be used for determining a position of a user equipment (mobile device). In certain example implementations, tones in positioning signals from one or more sources that may interfere with certain positioning signals be estimated and some form of interference mitigation may be applied, which may better enable the user equipment to acquire certain other positioning signals that may be useful in determining a position of the user equipment.

Abstract: Disclosed are devices and methods at a mobile device for processing a first downlink signal transmitted from a first cell transceiver in the presence of one or more second cell transceivers transmitting a second downlink signal using a four antenna port configuration. In an embodiment, the mobile device may process the first downlink signal so as to ameliorate effects of interference or jamming introduced by the second downlink signal.

Abstract: A mobile device position determination method includes: determining a plurality of bandwidths of a pilot signal corresponding to different times at which the pilot signal is received by a mobile device from a base station, the plurality of bandwidths of the pilot signal including a first bandwidth corresponding to a first time at which the pilot signal is received and a second bandwidth corresponding to a second time at which the pilot signal is received, the second time being after the first time; filtering the pilot signal using the second bandwidth; determining a positioning parameter from the pilot signal filtered using the second bandwidth; and determining a position of the mobile device using the positioning parameter.

Abstract: Techniques are provided, which may be used for determining a position of a user equipment (mobile device). In certain example implementations, tones in positioning signals from one or more sources that may interfere with certain positioning signals be estimated and some form of interference mitigation may be applied, which may better enable the user equipment to acquire certain other positioning signals that may be useful in determining a position of the user equipment.

Abstract: Techniques are provided, which may be used for determining a position of a user equipment (mobile device). In certain example implementations, tones in positioning signals from one or more sources that may interfere with certain positioning signals be estimated and some form of interference mitigation may be applied, which may better enable the user equipment to acquire certain other positioning signals that may be useful in determining a position of the user equipment.

Abstract: Techniques are provided, which may be used for determining a position of a user equipment (mobile device). In certain example implementations, tones in positioning signals from one or more sources that may interfere with certain positioning signals be estimated and some form of interference mitigation may be applied, which may better enable the user equipment to acquire certain other positioning signals that may be useful in determining a position of the user equipment.