Patents by Inventor Sheo Bux Singh
Sheo Bux Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7745644Abstract: Fermentation of a nutrient medium with a eubacterium Streptomyces sp. yields a novel antibacterial compound of structure (I).Type: GrantFiled: July 20, 2004Date of Patent: June 29, 2010Assignees: Merck Sharp & Dohme Corp., Merck Sharp and Dohme de Espana, S.A.Inventors: Angela Basilio, Olga Genilloud, Pilar Hernandez, Sheo Bux Singh, Jose Rueben Tormo, Jun Wang
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Publication number: 20080306139Abstract: Fermentation of a nutrient medium with a eubacterium Streptomyces sp. yields a novel antibacterial compound of structure (I).Type: ApplicationFiled: July 20, 2004Publication date: December 11, 2008Inventors: Angela Basilio, Olga Genilloud, Pilar Hernandez, Sheo Bux Singh, Jose Rueben Tormo, Jun Wang
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Patent number: 6908934Abstract: Compounds of Formula I and the pharmaceutically acceptable salts and esters thereof, wherein Z is selected from the group consisting of: (a) Formula Ia ?and (b) Formula Ib are novel LXR agonists and are useful in the treatment of dyslipidemic conditions particularly depressed levels of HDL cholesterol.Type: GrantFiled: May 30, 2002Date of Patent: June 21, 2005Assignee: Merck & Co., Inc.Inventors: Alan D. Adams, Aileen Bouffard, James F. Dropinski, Clare E. Gutteridge, A. Brian Jones, Weiguo Lui, John George Ondeyka, Ali Shiafee, Sheo Bux Singh
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Publication number: 20030125357Abstract: Compounds of Formula I 1Type: ApplicationFiled: May 30, 2002Publication date: July 3, 2003Inventors: Alan D. Adams, Aileen Bouffard, James F. Dropinski, Clare E. Gutteridge, A. Brian Jones, Weiguo Lui, John George Ondeyka, Ali Shiafee, Sheo Bux Singh
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Publication number: 20030086923Abstract: The instant invention provides a method for raising serum HDL cholesterol levels comprising administering a therapeutically effective amount of an LXR ligand to a patient in need of such treatment. It further provides a method for using an LXR ligand to stimulate expression of the ABC1 gene. LXR ligands can be used for preventing and treating atherosclerosis and related conditions.Type: ApplicationFiled: October 1, 2002Publication date: May 8, 2003Inventors: Carl P. Sparrow, John G. Ondeyka, Bruno Tse, Sheo Bux Singh
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Patent number: 6541515Abstract: Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines are described. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. The culture Cytospora sp. MF 6608 (ATCC PTA-1691) is also disclosed, as well as processes for making a compound of the present invention employing the culture.Type: GrantFiled: August 9, 2001Date of Patent: April 1, 2003Assignee: Merck & Co., Inc.Inventors: Sheo Bux Singh, Hiranthi Jayasuriya, Ziqiang Guan, Keith C. Silverman, Russell B. Lingham, Anne W. Dombrowski, Daria J. Hazuda, Jon D. Polishook
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Patent number: 6403347Abstract: Natural products such as certain chaetochromins are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.Type: GrantFiled: October 25, 1999Date of Patent: June 11, 2002Assignee: Merck & Co., Inc.Inventors: Gerald F. Bills, Russell B. Lingham, Ali Shafiee, Keith C. Silverman, Sheo Bux Singh, Deborah L. Zink, Fernando Pelaez, Ana M. Teran
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Publication number: 20020045658Abstract: Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines are described. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. The culture Cytospora sp. MF 6608 (ATCC PTA-1691) is also disclosed, as well as processes for making a compound of the present invention employing the culture.Type: ApplicationFiled: August 9, 2001Publication date: April 18, 2002Inventors: Sheo Bux Singh, Hiranthi Jayasuriya, Ziqiang Guan, Keith C. Silverman, Russell B. Lingham, Anne W. Dombrowski, Daria J. Hazuda, Jon D. Polishook
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Publication number: 20010014748Abstract: Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines are described. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. Further, the culture Fusarium sp., MF6381 (ATCC 74469) is also disclosed, as well as processes for making compounds of structural formula I employing the culture Fusarium sp., MF6381 (ATCC 74469).Type: ApplicationFiled: December 13, 1999Publication date: August 16, 2001Inventors: SHEO BUX SINGH, DEBORAH L. ZINK, DARIA JEAN HAZUDA, PETER J. FELOCK, JON DAVID POLISHOOK, ANNE W. DOMBROWSKI
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Patent number: 6271402Abstract: Compound of formula I: wherein the R groups are as defined by the specification. The compounds are useful in the inhibition of HIV integrase, the treatment of infection of HIV and treatment of AIDS.Type: GrantFiled: December 13, 1999Date of Patent: August 7, 2001Assignee: Merck & Co., Inc.Inventors: Sheo Bux Singh, Deborah L. Zink, Daria Jean Hazuda, Peter J. Felock, Anne W. Dombrowski
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Patent number: 6124327Abstract: Natural products such as certain dimerized hydroxyphenylundecanes are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.Type: GrantFiled: July 27, 1998Date of Patent: September 26, 2000Assignee: Merck & Co., Inc.Inventors: Keith C. Silverman, Russell B. Lingham, Sheo Bux Singh, Deborah L. Zink, Ana Teran
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Patent number: 6110716Abstract: Natural products such as certain chaetochromins are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.Type: GrantFiled: February 4, 1998Date of Patent: August 29, 2000Assignee: Merck & Co., Inc.Inventors: Russell B. Lingham, Ali Shafiee, Keith C. Silverman, Ana M. Teran, Sheo Bux Singh, Deborah L. Zink
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Patent number: 5945317Abstract: Novel compounds isolated from the fermentation of producing cultures of Nodulisporium sp. are antiparasitic and insecticidal agents.Type: GrantFiled: September 21, 1998Date of Patent: August 31, 1999Assignee: Merck & Co., Inc.Inventors: Kevin M. Byrne, Arlene M. Dahl, Anne Dombrowski, Joyce A. Greene, John G. Ondeyka, Dan A. Ostlind, Sheo Bux Singh, Diane M. Vesey
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Patent number: 5861375Abstract: The present invention provides novel cyclic tetrapeptides useful in the treatment or prevention of protozoal diseases; in particular, the novel compounds are active against the causative pathogens in malaria, toxoplasmosis, and coccidiosis.Type: GrantFiled: January 28, 1997Date of Patent: January 19, 1999Assignee: Merck & Co., Inc.Inventors: Christine Lange Cannova, Anne W. Dombrowski, Michael A. Goetz, Sandra J. Rattray, Sheo Bux Singh, Jon Polishook, Gerald F. Bills, Joyce A. Greene, Gary K. Darland
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Patent number: 5858738Abstract: Natural products such as certain ermophilane sesquiterpenoids and derivatives thereof are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. The fungal culture MF6254, Xylaria sp. (ATCC 74397) is also described and disclosed.Type: GrantFiled: November 4, 1997Date of Patent: January 12, 1999Assignee: Merck & Co., Inc.Inventors: Russell B. Lingham, Jon David Polishook, Ali Shafiee, Keith C. Silverman, Sheo Bux Singh, Deborah L. Zink
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Patent number: 5834260Abstract: Novel compounds isolated from the fermentation of producing cultures of Nodulisporium sp. are antiparasitic and insecticidal agents.Type: GrantFiled: August 20, 1997Date of Patent: November 10, 1998Assignee: Merck & Co., Inc.Inventors: Kevin M. Byrne, Arlene M. Dahl, Anne Dombrowski, Joyce A. Greene, John G. Ondeyka, Dan A. Ostlind, Sheo Bux Singh, Diane M. Vesey
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Patent number: 5759842Abstract: Natural products such as equisetin and derivatives are described. These compounds are useful in the inhibition of HIV integrase.Type: GrantFiled: October 24, 1996Date of Patent: June 2, 1998Assignee: Merck & Co., Inc.Inventors: Anne W. Dombrowski, Jeffrey C. Hastings, Daria Jean Hazuda, Jon David Polishook, Sheo Bux Singh
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Patent number: 5703067Abstract: The present invention is directed to steroidal or terpenoidal compounds which inhibit farnesyl-protein transferase (FPTase). The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer.Type: GrantFiled: May 8, 1995Date of Patent: December 30, 1997Assignee: Merck & Co., Inc.Inventors: Hiranthi Jayasuriya, Russell B. Lingham, Fernando Pelaez, Manuel Sanchez, Keith C. Silverman, Sheo Bux Singh, Deborah L. Zink