Patents by Inventor Sher Bahadur Karki

Sher Bahadur Karki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunoglobulin Variants Outside the Fc Region
    Publication number: 20080248028
    Abstract: The present invention relates to antibody variants outside the Fc region that alter binding affinity to one or more effector ligands, methods for their generation, and their therapeutic application.
    Type: Application
    Filed: August 20, 2007
    Publication date: October 9, 2008
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Sher Bahadur Karki
  • Fc variants with optimized properties
    Publication number: 20080242845
    Abstract: The present invention relates to Fc variants with optimized properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized properties, and methods for using Fc variants with optimized properties.
    Type: Application
    Filed: October 31, 2007
    Publication date: October 2, 2008
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Wei Dang, John R. Desjarlais, Sher Bahadur Karki
  • OPTIMIZED ANTIBODIES THAT TARGET HM1.24
    Publication number: 20080219974
    Abstract: The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one modification relative to a parent antibody that alters affinity to an Fc?R or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.
    Type: Application
    Filed: September 18, 2007
    Publication date: September 11, 2008
    Inventors: Matthew J. Bernett, John R. Desjarlais, Sher Bahadur Karki, Gregory Alan Lazar, Umesh S. Muchhal, Duc-Hanh Thi Nguyen, John O. Richards
  • Fc variants with optimized Fc receptor binding properties
    Publication number: 20080206867
    Abstract: The present invention relates to Fc variants with optimized Fc receptor binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc receptor binding properties, and methods for using Fc variants with optimized Fc receptor binding properties.
    Type: Application
    Filed: October 31, 2007
    Publication date: August 28, 2008
    Inventors: John R. Desjarlais, Sher Bahadur Karki, Gregory Alan Lazar, John O. Richards, Gregory L. Moore, David F. Carmichael
  • OPTIMIZED CD40 ANTIBODIES AND METHODS OF USING THE SAME
    Publication number: 20080199471
    Abstract: The present invention describes antibodies that target CD40, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fc?R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.
    Type: Application
    Filed: January 23, 2008
    Publication date: August 21, 2008
    Inventors: Matthew J. Bernett, Seung Yup Chu, John R. Desjarlais, Sher Bahadur Karki, Gregory Alan Lazar, Erik WeiKing Pong, Eugene Alexander Zhukovsky
  • Optimized Fc Variants and Methods for Their Generation
    Publication number: 20080181890
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 31, 2008
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen Kokl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Fc Variants with Increased Affinity for FcyRIIc
    Publication number: 20080161541
    Abstract: The present invention relates to Fc variants having increased affinity for Fc?RIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: August 20, 2007
    Publication date: July 3, 2008
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Wei Dang, John R. Desjarlais, Sher Bahadur Karki, Omid Vafa, Robert Hayes
  • Fc Variants with Increased Affinity for FcyRIIc
    Publication number: 20080154025
    Abstract: The present invention relates to Fc variants having increased affinity for Fc?RIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: August 20, 2007
    Publication date: June 26, 2008
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Wei Dang, John R. Desjarlais, Sher Bahadur Karki, Omid Vafa, Robert Hayes
  • Optimized Fc variants
    Patent number: 7317091
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: January 8, 2008
    Assignee: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Immunoglobulin variants outside the Fc region
    Patent number: 7276585
    Abstract: The present invention relates to antibody variants outside the Fc region that alter binding affinity to one or more effector ligands, methods for their generation, and their therapeutic application.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: October 2, 2007
    Assignee: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Sher Bahadur Karki
  • Optimized Fc variants and methods for their generation
    Publication number: 20040132101
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: September 26, 2003
    Publication date: July 8, 2004
    Applicant: Xencor
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John Rudolph Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa