Patents by Inventor Shereen Ibrahim

Shereen Ibrahim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of preparing substituted nucleotide analogs
    Patent number: 8895723
    Abstract: Disclosed herein are methods of preparing a phosphorothioate nucleotide analog, which are useful in treating diseases and/or conditions such as viral infections.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: November 25, 2014
    Assignees: Alios BioPharma, Inc., Vertex Pharmaceuticals Inc.
    Inventors: Vladimir Serebryany, Jyanwei Liu, Leonid Beigelman, Young Chun Jung, Peter Jamison Rose, Shereen Ibrahim, Cavan McKeon Bligh, Luigi Anzalone
  • METHODS OF STEREOSELECTIVE SYNTHESIS OF SUBSTITUTED NUCLEOSIDE ANALOGS
    Publication number: 20140309413
    Abstract: The present invention relates to the novel diastereoselective syntheses for generating phosphorothioate compounds. Examples include nucleoside phosphorothioate analogs that are useful in treating diseases and/or conditions such as viral infections.
    Type: Application
    Filed: March 10, 2014
    Publication date: October 16, 2014
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Peter Jamison Rose, Young Chun Jung, Cavan McKeon Bligh, Shereen Ibrahim, Luigi Anzalone, David B. Miller, JR., John Gregg Van Alsten, Timothy Thomas Curran
  • Methods of preparing substituted nucleotide analogs
    Patent number: 8846896
    Abstract: Disclosed herein are methods of preparing a phosphorothioate nucleotide analog, which are useful in treating diseases and/or conditions such as viral infections.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: September 30, 2014
    Inventors: Vladimir Serebryany, Jyanwei Liu, Leonid Beigelman, Young Chun Jung, Jamison Rose, Shereen Ibrahim, Cavan McKeon, Luigi Anzalone
  • Preparation of protected alpha-keto beta-amino esters and amides
    Patent number: 8378124
    Abstract: The invention provides ?-sulfonamide ?-keto esters and amides in which the ?-keto is protected as a 1,3-dithiolane derivative. Also provided are methods for preparing such esters and amides and for incorporating them into peptides.
    Type: Grant
    Filed: December 30, 2010
    Date of Patent: February 19, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: William A. Nugent, Adam R. Looker, Raymond E. Forslund, Theodore A. Martinot, Cristian L. Harrison, Shereen Ibrahim
  • Aminopyrazole triazolothiadiazole inhibitor of c-Met protein kinase
    Patent number: 8263777
    Abstract: The present invention relates to anhydrous and hydrated forms of Compound 1, which are useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula I and methods of using the compositions in the treatment of proliferative disorders.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: September 11, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David J. Lauffer, Pan Li, Stefanie Roeper, Shereen Ibrahim, Anuj K. Kuldipkumar, Yi Shi, David B. Miller, Jr.
  • AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITOR OF C-MET PROTEIN KINASE
    Publication number: 20110294849
    Abstract: The present invention relates to anhydrous and hydrated forms of Compound 1, which qre useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula I and methods of using the compositions in the treatment of proliferative disorders.
    Type: Application
    Filed: May 24, 2011
    Publication date: December 1, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: David J. Lauffer, Pan Li, Stefanie Roeper, Shereen Ibrahim, Anuj K. Kuldipkumar, Yi Shi, David B. Miller, JR.
  • Preparation of Protected Alpha-Keto Beta-Amino Esters and Amides
    Publication number: 20110213161
    Abstract: The invention provides ?-sulfonamide ?-keto esters and amides in which the ?-keto is protected as a 1,3-dithiolane derivative. Also provided are methods for preparing such esters and amides and for incorporating them into peptides.
    Type: Application
    Filed: December 30, 2010
    Publication date: September 1, 2011
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: William A. Nugent, Adam R. Looker, Raymond E. Forslund, Theodore A. Martinot, Cristian L. Harrison, Shereen Ibrahim