Abstract: Methods for producing mono-specific immunoglobin Y (IgY) antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are disclosed. IgY antibodies are found in birds and can be isolated from egg yolk of chicken eggs. Hens are immunized with a SARS-CoV-2 spike protein comprising an ACE2 receptor binding domain (RBD). IgY antibodies against the RBD are isolated from eggs laid by the hens. The isolated RBD-IgY antibodies were tested in vitro in mammalian cells, wherein the RBD-IgY blocked SARS-CoV-2 infection of the cells. A pharmaceutical composition comprising the mono-specific IgY antibodies can be used to inhibit or treat COOVID-19, the SARS-CoV-2 infection. IgY antibodies are generally regarded as safe and offer various production and treatment advantages when compared to mammalian antibodies.

Abstract: Chicken egg yolk antibodies (IgY Abs) specific to the Middle Eastern Respiratory Syndrome coronavirus spike (MERS-CoV S) protein demonstrate efficacy against MERS-CoV infection. The S-specific IgY Abs (anti-S IgY) are produced by injecting chickens with purified a recombinant MERS-CoV S protein, S1 subunit, or an S1 fragment. The purified anti-S IgY specifically bind to the MERS-CoV S protein and inhibit infection. In vitro neutralization of the IgY Abs against MERS-CoV was achieved in cell lines and in a human-transgenic mouse model treated with a pharmaceutical composition comprising the anti-S IgY. Viral antigen-positive cells in treated mice were reduced, compared to the adjuvant-only controls. Moreover, lung cells of anti-S IgY-treated mice showed significantly reduced inflammation, compared to the controls. Efficient neutralization of MERS-CoV infection is demonstrated both in vitro and in vivo using the anti-S IgY Abs.

Abstract: A closure mechanism receiving aperture presents a substantially contiguous, uninterrupted planar surface on a flexible medium, primarily for use with identification devices, i.e., wristbands. The aperture does not interrupt the printable area so that printer ink may be printed over the aperture without passing through. The inventive aperture also does not produce waster material or chads which can jam or foul-up a printer. An inventive wristband includes both snap closure and adhesive closure mechanisms that can be used at the same time.

Abstract: A multi-part form includes a wristband with related tags and labels. The tags are configured for mounting on the wristband after the wristband has been secured to a person of object to be identified. The multi-part form is also configured with a wristband portion separate from a plurality of utility groups, each of which is separate from the other, by a street devoid of media layer. The layers that comprise the multi-part form are preferably solvent resistant so as to make the identification products more durable and longer lasting.

Abstract: A closure mechanism receiving aperture presents a substantially contiguous, uninterrupted planar surface on a flexible medium, primarily for use with identification devices, i.e., wristbands. The aperture does not interrupt the printable area so that printer ink may be printed over the aperture without passing through. The inventive aperture also does not produce waster material or chads which can jam or foul-up a printer. An inventive wristband includes both snap closure and adhesive closure mechanisms that can be used at the same time.

Abstract: A closure mechanism receiving aperture presents a substantially contiguous, uninterrupted planar surface on a flexible medium, primarily for use with identification devices, i.e., wristbands. The aperture does not interrupt the printable area so that printer ink may be printed over the aperture without passing through. The inventive aperture also does not produce waster material or chads which can jam or foul-up a printer. An inventive wristband includes both snap closure and adhesive closure mechanisms that can be used at the same time.

Abstract: The wristband system includes a tag having an identification area for receiving information associated with an object to be identified. A dual attachment mechanism is associated with the tag and generally includes a slit in the tag and an adhesive disposed on at least a portion of the tag. The wristband system further includes an elongated flexible strap having a fastener for retaining the strap in a closed loop configuration around the object to be identified. In turn, the tag is configured to fixedly attach to the strap by threaded engagement of the slit or retention by the adhesive.

Abstract: A multi-part form includes a wristband with related tags and labels. The tags are configured for mounting on the wristband after the wristband has been secured to a person of object to be identified. The multi-part form is also configured with a wristband portion separate from a plurality of utility groups, each of which is separate from the other, by a street devoid of media layer. The layers that comprise the multi-part form are preferably solvent resistant so as to make the identification products more durable and longer lasting.

Abstract: A closure mechanism receiving aperture presents a substantially contiguous, uninterrupted planar surface on a flexible medium, primarily for use with identification devices, i.e., wristbands. The aperture does not interrupt the printable area so that printer ink may be printed over the aperture without passing through. The inventive aperture also does not produce waster material or chads which can jam or foul-up a printer. An inventive wristband includes both snap closure and adhesive closure mechanisms that can be used at the same time.

Abstract: A plurality of identification bracelets removably attached to one another, each bracelet having a first end which includes a cover tab and a second end defining a closure tab having an adhesive portion. The cover tab of a second bracelet removably overlies the adhesive portion of a closure tab of an adjacent first identification bracelet. Upon separating the first and second bracelets, the adhesive portion of the first bracelet is exposed and the cover tab remains with the second bracelet as it is removed. The adhesive portion of the closure tab of the first bracelet is adhered to a surface of the first bracelet as it is moved from an open position to a closed position encircling an object to be identified.

Abstract: A plurality of identification bracelets removably attached to one another, each bracelet having a first end which includes a cover tab and a second end defining a closure tab having an adhesive portion. The cover tab of a second bracelet removably overlies the adhesive portion of a closure tab of an adjacent first identification bracelet. Upon separating the first and second bracelets, the adhesive portion of the first bracelet is exposed and the cover tab remains with the second bracelet as it is removed. The adhesive portion of the closure tab of the first bracelet, is adhered to a surface of the identification bracelet as it is moved from an open position to a closed position encircling an object to be identified. The bracelets may be connected end-to-end to form an elongated strip or along elongated side edges to form a sheet of identification bracelets.

Abstract: A flexible, substantially non-stretchable, imprintable tape which includes lines of weakness constituting tear lines defining in outline a longitudinal series of identification bracelets. Each bracelet has a generally rectangular imprintable portion, an elongated strap portion at one end of the imprintable portion, and a stubby strap portion at an opposite end of the imprintable portion. The imprintable portion has a width equal to the width of the tape and the elongated and stubby portions each have a width less than that of the tape. The elongated strap portion has a longitudinal edge aligned with one of the side edges of the tape and an opposite longitudinal edge defined by one of the lines of weakness. The stubby strap portion has a longitudinal edge aligned with an opposite side edge of the tape relative to the elongated strap portion and an opposite longitudinal edge defined by another one of the lines of weakness.