Patents by Inventor Sherri Marie Brown

Sherri Marie Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic DNA sequences having enhanced expression in monocotyledonous plants and method for preparation thereof
    Patent number: 6180774
    Abstract: A method for modifying a foreign nucleotide sequence for enhanced accumulation of its protein product in a monocotyledonous plant and/or increasing the frequency of obtaining transgenic monocotyledonous plants which accumulate useful amounts of a transgenic protein by reducing the frequency of the rare and semi-rare monocotyledonous codons in the foreign gene and replacing them with more preferred monocotyledonous codons is disclosed. In addition, a method for enhancing the accumulation of a polypeptide encoded by a nucleotide sequence in a monocotyledonous plant and/or increasing the frequency of obtaining transgenic monocotyledonous plants which accumulate useful amounts of a transgenic protein by analyzing the coding sequence in successive six nucleotide fragments and altering the sequence based on the frequency of appearance of the six-mers as to the frequency of appearance of the rarest 284, 484, and 664 six-mers in monocotyledonous plants is provided.
    Type: Grant
    Filed: August 5, 1997
    Date of Patent: January 30, 2001
    Assignee: Monsato Company
    Inventors: Sherri Marie Brown, Duff Allen Dean, Michael Ernest Fromm, Patricia Rigden Sanders
  • Enhanced expression in plants
    Patent number: 5859347
    Abstract: This invention provides HSP70 introns that when present in a non-translated leader of a chimeric gene enhance expression in plants.
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: January 12, 1999
    Assignee: Monsanto Company
    Inventors: Sherri Marie Brown, Colleen Gail Santino
  • Synthetic DNA sequences having enhanced expression in monocotyledonous plants and method for preparation thereof
    Patent number: 5689052
    Abstract: A method for modifying a foreign nucleotide sequence for enhanced accumulation of its protein product in a monocotyledonous plant and/or increasing the frequency of obtaining transgenic monocotyledonous plants which accumulate useful amounts of a transgenic protein by reducing the frequency of the rare and semi-rare monocotyledonous codons in the foreign gene and replacing them with more preferred monocotyledonous codons is disclosed. In addition, a method for enhancing the accumulation of a polypeptide encoded by a nucleotide sequence in a monocotyledonous plant and/or increasing the frequency of obtaining transgenic monocotyledonous plants which accumulate useful amounts of a transgenic protein by analyzing the coding sequence in successive six nucleotide fragments and altering the sequence based on the frequency of appearance of the six-mers as to the frequency of appearance of the rarest 284, 484, and 664 six-mers in monocotyledonous plants is provided.
    Type: Grant
    Filed: September 19, 1995
    Date of Patent: November 18, 1997
    Assignee: Monsanto Company
    Inventors: Sherri Marie Brown, Duff Allen Dean, Michael Ernest Fromm, Patricia Rigden Sanders