Patents by Inventor Sheryl S. Justice

Sheryl S. Justice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LPS serotypes for determining severity of urinary tract infection
    Patent number: 10214781
    Abstract: A method of identifying a subject having a urinary tract infection posing a significant risk of dangerous sequalae is described. The method includes obtaining a urine or fecal sample from the subject; determining the predominant LPS O-antigen serotype in the sample; and comparing the predominant LPS O-antigen serotype to a set of febrile UTI LPS serotypes. The method can also include treating the subject for UTI if the predominant O-antigen LPS serotype is a febrile UTI LPS serotype.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: February 26, 2019
    Assignee: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
    Inventors: Sheryl S. Justice, Kevin M. Mason
  • Treatment of otitis media
    Patent number: 10000577
    Abstract: A method of treating otitis media in a subject is described that includes administering to the subject a therapeutically effective amount of an Actin-Related Protein 2/3 Complex (Arp2/3) inhibitor. The role of Arp2/3 in otitis media was identified using comprehensive proteomic and metabolomic studies of otitis media using the chinchilla model.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: June 19, 2018
    Assignee: Research Institute At Nationwide Children's Hospital
    Inventors: Sheryl S. Justice, Kevin M. Mason, Alistair Harrison
  • TREATMENT OF OTITIS MEDIA
    Publication number: 20170275379
    Abstract: A method of treating otitis media in a subject is described that includes administering to the subject a therapeutically effective amount of an Actin-Related Protein 2/3 Complex (Arp2/3) inhibitor. The role of Arp2/3 in otitis media was identified using comprehensive proteomic and metabolomic studies of otitis media using the chinchilla model.
    Type: Application
    Filed: September 11, 2015
    Publication date: September 28, 2017
    Inventors: Sheryl S. Justice, Kevin M. Mason, Alistair Harrison
  • Compositions and methods for the prevention of microbial infections
    Patent number: 9745366
    Abstract: This disclosure provides methods and compositions to inhibit or prevent infection of a cell by a bacteria that exports DNABII proteins by administering to a tissue infected with the bacteria an effective amount of an antibody that specifically recognizes and binds the DNABII proteins, thereby inhibiting or preventing infection of the bacteria. Treatment methods, screens and kits are further provided.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: August 29, 2017
    Assignees: University of Southern California, Research Institute at Nationwide Children's Hospital
    Inventors: Steven D. Goodman, Sheryl S. Justice
  • LPS SEROTYPES FOR DETERMINING SEVERITY OF URINARY TRACT INFECTION
    Publication number: 20160312270
    Abstract: A method of identifying a subject having a urinary tract infection posing a significant risk of dangerous sequalae is described. The method includes obtaining a urine or fecal sample from the subject; determining the predominant LPS O-antigen serotype in the sample; and comparing the predominant LPS O-antigen serotype to a set of febrile UTI LPS serotypes. The method can also include treating the subject for UTI if the predominant O-antigen LPS serotype is a febrile UTI LPS serotype.
    Type: Application
    Filed: June 13, 2016
    Publication date: October 27, 2016
    Inventors: Sheryl S. Justice, Kevin M. Mason
  • COMPOSITIONS AND METHODS FOR THE PREVENTION OF MICROBIAL INFECTIONS
    Publication number: 20150086542
    Abstract: This disclosure provides methods and compositions to inhibit or prevent infection of a cell by a bacteria that exports DNABII proteins by administering to a tissue infected with the bacteria an effective amount of an antibody that specifically recognizes and binds the DNABII proteins, thereby inhibiting or preventing infection of the bacteria. Treatment methods, screens and kits are further provided.
    Type: Application
    Filed: September 22, 2014
    Publication date: March 26, 2015
    Inventors: Steven D. Goodman, Sheryl S. Justice