Patents by Inventor Sheryl T. Smith

Sheryl T. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mammalian and human REC2
    Patent number: 6410226
    Abstract: The invention concerns mammalian recombinase genes (REC2) and their promoters. Over expression of REC2 in a cell is found to facilitate homologous recombination, particularly homologous recombination using a DNA/RNA chimeric oligonucleotide and to sensitize a cell to the apoptotic effects of irradiation. The REC2 promoter, in combination with a strong enhancer, e.g., a SV40 enhancer, was found to be a strong promoter following irradiation of the cells. A radiation induceable promoter can be used to sensitize a cell to radiation treatment by operably linking the radiation induceable promoter to a gene whose expression converts a prodrug to a drug such as a herpes thymidien kinase gene.
    Type: Grant
    Filed: September 11, 1997
    Date of Patent: June 25, 2002
    Assignees: Thomas Jefferson University, Cornell Research Foundation, Inc.
    Inventors: Eric B. Kmiec, William K. Holloman, Michael C. Rice, Sheryl T. Smith, Zhigang Shu