Abstract: The present invention relates to the field of biomedical technology, and particularly relates to a composition with anti-aging properties, which comprises spermidine and resveratrol. The invention provides a method for selecting a composition with anti-aging properties, and the anti-aging properties of the composition were confirmed by lifespan analysis, cell viability analysis and staining analysis using materials such as Caenorhabditis elegans and mouse embryonic fibroblasts etc. The composition can be used to improve life-span, as anti-aging drugs and nutritional products. The invention also discloses the preferred concentrations of spermidine and resveratrol in the composition, where the preferred concentration of spermidine is 200 ?M and the preferred concentration of resveratrol is 10 ?M. The method as provided by the invention is versatile, and the provided compositions can be used in drug preparation and epidemic medicine.

Abstract: The invention relates to the technical field of medicine, and provides a method of screening and identifying small molecule with anti-aging properties. The method comprises cellular models, namely premature aging mouse embryonic fibroblasts and human HGPS mesenchymal stem cells and animal models, namely premature aging progeroid mice and Caenorhabditis elegans. The method successfully screened and identified Cannabidiol (CBD), which had senolytic effects. The invention also determined that the optimal concentration of CBD treatment is 10-20 ?M.

Abstract: The invention relates to the technical field of medicine, and provides a method of screening and identifying small molecule with antiviral properties. The invention has screened and identified Cannabidiol (CBD), which can be used for prevention of viral infections. The invention also examined and verified that CBD can be used for prevention of COVID-19 disease, by a key signaling pathway of upregulating the expression of the TRIB3 gene. The invention also determined that the optimal dosage of CBD treatment for prevention of COVID-19 disease is 5 ?M-10 ?M.